CSF2R_MOUSE
ID CSF2R_MOUSE Reviewed; 388 AA.
AC Q00941; E9QJX0;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Granulocyte-macrophage colony-stimulating factor receptor subunit alpha;
DE Short=GM-CSF-R-alpha;
DE Short=GMCSFR-alpha;
DE Short=GMR-alpha;
DE AltName: CD_antigen=CD116;
DE Flags: Precursor;
GN Name=Csf2ra; Synonyms=Csfgmra;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Neonatal spleen;
RX PubMed=1533931; DOI=10.1073/pnas.89.10.4295;
RA Park L.S., Martin U., Sorensen R., Luhr S., Morrissey P.J., Cosman D.,
RA Larsen A.;
RT "Cloning of the low-affinity murine granulocyte-macrophage colony-
RT stimulating factor receptor and reconstitution of a high-affinity receptor
RT complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:4295-4299(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Low affinity receptor for granulocyte-macrophage colony-
CC stimulating factor. Transduces a signal that results in the
CC proliferation, differentiation, and functional activation of
CC hematopoietic cells.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. The beta subunit
CC is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF
CC receptor complex is a dodecamer of two head-to-head hexamers of two
CC alpha, two beta, and two ligand subunits (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding.
CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC activation.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
CC subfamily. {ECO:0000305}.
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DR EMBL; M85078; AAA37421.1; -; mRNA.
DR EMBL; AC165327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS29946.1; -.
DR PIR; A45304; A45304.
DR RefSeq; NP_034100.2; NM_009970.2.
DR AlphaFoldDB; Q00941; -.
DR SMR; Q00941; -.
DR STRING; 10090.ENSMUSP00000075423; -.
DR GlyGen; Q00941; 6 sites.
DR PhosphoSitePlus; Q00941; -.
DR SwissPalm; Q00941; -.
DR PaxDb; Q00941; -.
DR PRIDE; Q00941; -.
DR ProteomicsDB; 285346; -.
DR Antibodypedia; 4251; 755 antibodies from 42 providers.
DR DNASU; 12982; -.
DR Ensembl; ENSMUST00000076046; ENSMUSP00000075423; ENSMUSG00000059326.
DR Ensembl; ENSMUST00000237386; ENSMUSP00000158457; ENSMUSG00000059326.
DR GeneID; 12982; -.
DR KEGG; mmu:12982; -.
DR UCSC; uc008icj.2; mouse.
DR CTD; 1438; -.
DR MGI; MGI:1339754; Csf2ra.
DR VEuPathDB; HostDB:ENSMUSG00000059326; -.
DR eggNOG; ENOG502RZVR; Eukaryota.
DR GeneTree; ENSGT00520000055993; -.
DR HOGENOM; CLU_039627_2_0_1; -.
DR InParanoid; Q00941; -.
DR OMA; DIQTEYV; -.
DR OrthoDB; 1201451at2759; -.
DR PhylomeDB; Q00941; -.
DR TreeFam; TF331549; -.
DR Reactome; R-MMU-512988; Interleukin-3, Interleukin-5 and GM-CSF signaling.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-5683826; Surfactant metabolism.
DR Reactome; R-MMU-912526; Interleukin receptor SHC signaling.
DR BioGRID-ORCS; 12982; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Csf2ra; mouse.
DR PRO; PR:Q00941; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q00941; protein.
DR Bgee; ENSMUSG00000059326; Expressed in granulocyte and 238 other tissues.
DR Genevisible; Q00941; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0030526; C:granulocyte macrophage colony-stimulating factor receptor complex; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0038157; P:granulocyte-macrophage colony-stimulating factor signaling pathway; ISO:MGI.
DR GO; GO:0070665; P:positive regulation of leukocyte proliferation; ISO:MGI.
DR GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; ISO:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040907; IL3Ra_N.
DR InterPro; IPR003532; Short_hematopoietin_rcpt_2_CS.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR Pfam; PF18611; IL3Ra_N; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01356; HEMATOPO_REC_S_F2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..388
FT /note="Granulocyte-macrophage colony-stimulating factor
FT receptor subunit alpha"
FT /id="PRO_0000010873"
FT TOPO_DOM 30..327
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 349..388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 228..324
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT MOTIF 310..314
FT /note="WSXWS motif"
FT MOTIF 359..367
FT /note="Box 1 motif"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 124
FT /note="G -> S (in Ref. 1; AAA37421)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 388 AA; 41769 MW; 8877B0743D99B0FE CRC64;
MTSSHAMNIT PLAQLALLFS TLLLPGTQAL LAPTTPDAGS ALNLTFDPWT RTLTWACDTA
AGNVTVTSCT VTSREAGIHR RVSPFGCRCW FRRMMALHHG VTLDVNGTVG GAAAHWRLSF
VNEGAAGSGA ENLTCEIRAA RFLSCAWREG PAAPADVRYS LRVLNSTGHD VARCMADPGD
DVITQCIAND LSLLGSEAYL VVTGRSGAGP VRFLDDVVAT KALERLGPPR DVTASCNSSH
CTVSWAPPST WASLTARDFQ FEVQWQSAEP GSTPRKVLVV EETRLAFPSP APHGGHKVKV
RAGDTRMKHW GEWSPAHPLE AEDTRVPGAL LYAVTACAVL LCALALGVTC RRFEVTRRLF
PPIPGIRDKV SDDVRVNPET LRKDLLQP
