ID   CSF2_BOVIN              Reviewed;         143 AA.
AC   P11052;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Granulocyte-macrophage colony-stimulating factor;
DE            Short=GM-CSF;
DE   AltName: Full=Colony-stimulating factor;
DE            Short=CSF;
DE   Flags: Precursor;
GN   Name=CSF2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3062386; DOI=10.1016/0161-5890(88)90120-4;
RA   Maliszewski C.R., Schoenborn M.A., Cerretti D.P., Wignall J.M., Picha K.S.,
RA   Cosman D., Tushinski R.J., Gillis S., Baker P.E.;
RT   "Bovine GM-CSF: molecular cloning and biological activity of the
RT   recombinant protein.";
RL   Mol. Immunol. 25:843-850(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2678728; DOI=10.1016/0165-2427(89)90036-6;
RA   Leong S.R., Flaggs G.M., Lawman M.J.P., Gray P.W.;
RT   "Cloning and expression of the cDNA for bovine granulocyte-macrophage
RT   colony-stimulating factor.";
RL   Vet. Immunol. Immunopathol. 21:261-278(1989).
CC   -!- FUNCTION: Cytokine that stimulates the growth and differentiation of
CC       hematopoietic precursor cells from various lineages, including
CC       granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a dodecamer
CC       of two head-to-head hexamers of two alpha, two beta, and two ligand
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
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DR   EMBL; U22385; AAA66075.1; -; mRNA.
DR   PIR; JL0037; FQBOGM.
DR   RefSeq; NP_776452.1; NM_174027.2.
DR   AlphaFoldDB; P11052; -.
DR   SMR; P11052; -.
DR   STRING; 9913.ENSBTAP00000002054; -.
DR   PaxDb; P11052; -.
DR   PRIDE; P11052; -.
DR   Ensembl; ENSBTAT00000002054; ENSBTAP00000002054; ENSBTAG00000001570.
DR   GeneID; 281095; -.
DR   KEGG; bta:281095; -.
DR   CTD; 1437; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001570; -.
DR   VGNC; VGNC:27755; CSF2.
DR   eggNOG; ENOG502TDUI; Eukaryota.
DR   GeneTree; ENSGT00390000013425; -.
DR   HOGENOM; CLU_152286_0_0_1; -.
DR   InParanoid; P11052; -.
DR   OMA; VTRPWKH; -.
DR   OrthoDB; 1412355at2759; -.
DR   TreeFam; TF338611; -.
DR   Reactome; R-BTA-512988; Interleukin-3, Interleukin-5 and GM-CSF signaling.
DR   Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-BTA-912526; Interleukin receptor SHC signaling.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000001570; Expressed in intramuscular adipose tissue and 19 other tissues.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0030526; C:granulocyte macrophage colony-stimulating factor receptor complex; IEA:Ensembl.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR   GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
DR   GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
DR   GO; GO:0038157; P:granulocyte-macrophage colony-stimulating factor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0072651; P:interferon-tau production; ISS:AgBase.
DR   GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR   GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
DR   GO; GO:0030099; P:myeloid cell differentiation; IBA:GO_Central.
DR   GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
DR   GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
DR   GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
DR   GO; GO:0070665; P:positive regulation of leukocyte proliferation; IEA:Ensembl.
DR   GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
DR   GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR   GO; GO:1904075; P:positive regulation of trophectodermal cell proliferation; ISS:AgBase.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   CDD; cd00040; CSF2; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000773; GM_colony-stim-fac.
DR   PANTHER; PTHR10059; PTHR10059; 1.
DR   Pfam; PF01109; GM_CSF; 1.
DR   PRINTS; PR00693; GMCSFACTOR.
DR   SMART; SM00040; CSF2; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00702; GM_CSF; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..17
FT   CHAIN           18..143
FT                   /note="Granulocyte-macrophage colony-stimulating factor"
FT                   /id="PRO_0000005860"
FT   CARBOHYD        27
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        70..112
FT                   /evidence="ECO:0000250"
FT   DISULFID        104..137
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   143 AA;  16157 MW;  4A24E26A870A51EC CRC64;
     MWLQNLLLLG TVVCSFSAPT RPPNTATRPW QHVDAIKEAL SLLNHSSDTD AVMNDTEVVS
     EKFDSQEPTC LQTRLKLYKN GLQGSLTSLM GSLTMMATHY EKHCPPTPET SCGTQFISFK
     NFKEDLKEFL FIIPFDCWEP AQK