CSF2_CANLF
ID CSF2_CANLF Reviewed; 144 AA.
AC P48749;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Granulocyte-macrophage colony-stimulating factor;
DE Short=GM-CSF;
DE AltName: Full=Colony-stimulating factor;
DE Short=CSF;
DE Flags: Precursor;
GN Name=CSF2;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1868252;
RA Nash R.A., Schuening F., Appelbaum F.R., Hammond W.P., Boone T.,
RA Morris C.F., Slichter S.J., Storb R.;
RT "Molecular cloning and in vivo evaluation of canine granulocyte-macrophage
RT colony-stimulating factor.";
RL Blood 78:930-937(1991).
CC -!- FUNCTION: Cytokine that stimulates the growth and differentiation of
CC hematopoietic precursor cells from various lineages, including
CC granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a dodecamer
CC of two head-to-head hexamers of two alpha, two beta, and two ligand
CC subunits (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
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DR EMBL; S49738; AAB19466.1; -; mRNA.
DR PIR; A44936; A44936.
DR RefSeq; NP_001003245.1; NM_001003245.1.
DR RefSeq; XP_005626428.1; XM_005626371.1.
DR RefSeq; XP_005626429.1; XM_005626372.1.
DR AlphaFoldDB; P48749; -.
DR SMR; P48749; -.
DR STRING; 9612.ENSCAFP00000001176; -.
DR PaxDb; P48749; -.
DR Ensembl; ENSCAFT00030023256; ENSCAFP00030020283; ENSCAFG00030012563.
DR Ensembl; ENSCAFT00040010702; ENSCAFP00040009281; ENSCAFG00040005704.
DR GeneID; 403923; -.
DR KEGG; cfa:403923; -.
DR CTD; 1437; -.
DR eggNOG; ENOG502TDUI; Eukaryota.
DR HOGENOM; CLU_152286_0_0_1; -.
DR InParanoid; P48749; -.
DR OrthoDB; 1412355at2759; -.
DR Reactome; R-CFA-512988; Interleukin-3, Interleukin-5 and GM-CSF signaling.
DR Reactome; R-CFA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-CFA-912526; Interleukin receptor SHC signaling.
DR Proteomes; UP000002254; Unplaced.
DR Bgee; ENSCAFG00000000820; Expressed in testis and 11 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0030526; C:granulocyte macrophage colony-stimulating factor receptor complex; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
DR GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
DR GO; GO:0038157; P:granulocyte-macrophage colony-stimulating factor signaling pathway; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
DR GO; GO:0030099; P:myeloid cell differentiation; IBA:GO_Central.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
DR GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
DR GO; GO:0070665; P:positive regulation of leukocyte proliferation; IEA:Ensembl.
DR GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
DR GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR CDD; cd00040; CSF2; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000773; GM_colony-stim-fac.
DR PANTHER; PTHR10059; PTHR10059; 1.
DR Pfam; PF01109; GM_CSF; 1.
DR PRINTS; PR00693; GMCSFACTOR.
DR SMART; SM00040; CSF2; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00702; GM_CSF; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000250"
FT CHAIN 18..144
FT /note="Granulocyte-macrophage colony-stimulating factor"
FT /id="PRO_0000005861"
FT CARBOHYD 22
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250"
FT CARBOHYD 27
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 71..113
FT /evidence="ECO:0000250"
FT DISULFID 105..138
FT /evidence="ECO:0000250"
SQ SEQUENCE 144 AA; 16137 MW; 6323807E1F1C6343 CRC64;
MWLQNLLFLG TVVCSISAPT RSPTLVTRPS QHVDAIQEAL SLLNNSNDVT AVMNKAVKVV
SEVFDPEGPT CLETRLQLYK EGLQGSLTSL KNPLTMMANH YKQHCPPTPE SPCATQNINF
KSFKENLKDF LFNIPFDCWK PVKK
