ID   CSF2_CAVPO              Reviewed;         140 AA.
AC   Q60481;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Granulocyte-macrophage colony-stimulating factor;
DE            Short=GM-CSF;
DE   AltName: Full=Colony-stimulating factor;
DE            Short=CSF;
DE   Flags: Precursor; Fragment;
GN   Name=CSF2;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley; TISSUE=Lung;
RA   Yuan H.T., Kelly F.J., Bingle C.D.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine that stimulates the growth and differentiation of
CC       hematopoietic precursor cells from various lineages, including
CC       granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a dodecamer
CC       of two head-to-head hexamers of two alpha, two beta, and two ligand
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
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DR   EMBL; U46779; AAA87592.1; -; mRNA.
DR   AlphaFoldDB; Q60481; -.
DR   SMR; Q60481; -.
DR   STRING; 10141.ENSCPOP00000012677; -.
DR   eggNOG; ENOG502TDUI; Eukaryota.
DR   InParanoid; Q60481; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR   GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00040; CSF2; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000773; GM_colony-stim-fac.
DR   PANTHER; PTHR10059; PTHR10059; 1.
DR   Pfam; PF01109; GM_CSF; 1.
DR   PRINTS; PR00693; GMCSFACTOR.
DR   SMART; SM00040; CSF2; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00702; GM_CSF; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..>140
FT                   /note="Granulocyte-macrophage colony-stimulating factor"
FT                   /id="PRO_0000005862"
FT   CARBOHYD        24
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        27
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        55
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        72..114
FT                   /evidence="ECO:0000250"
FT   DISULFID        106..139
FT                   /evidence="ECO:0000250"
FT   NON_TER         140
SQ   SEQUENCE   140 AA;  15869 MW;  FF72E7A9491C831C CRC64;
     MWLQNLLLLG TVVCSICAPT DLLSPVTQSW KHVDATINEA LSLLNHTSDP AAVMNETVEV
     VYDQFEPQEP TCLQTRLALF MKGLRGNLTR LEGSLTLMAN FYKQHCPPTP ETSCMTQIIT
     FKSFKENLKR FLFAIPFDCW