ID   CSF2_FELCA              Reviewed;         144 AA.
AC   O62757;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Granulocyte-macrophage colony-stimulating factor;
DE            Short=GM-CSF;
DE   AltName: Full=Colony-stimulating factor;
DE            Short=CSF;
DE   Flags: Precursor;
GN   Name=CSF2;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hughes K.J., O'Reilly K.L.;
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine that stimulates the growth and differentiation of
CC       hematopoietic precursor cells from various lineages, including
CC       granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a dodecamer
CC       of two head-to-head hexamers of two alpha, two beta, and two ligand
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
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DR   EMBL; AF053007; AAC06041.1; -; mRNA.
DR   RefSeq; NP_001009846.1; NM_001009846.1.
DR   AlphaFoldDB; O62757; -.
DR   SMR; O62757; -.
DR   STRING; 9685.ENSFCAP00000003553; -.
DR   GeneID; 493805; -.
DR   CTD; 1437; -.
DR   eggNOG; ENOG502TDUI; Eukaryota.
DR   InParanoid; O62757; -.
DR   TreeFam; TF338611; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR   GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0030099; P:myeloid cell differentiation; IBA:GO_Central.
DR   CDD; cd00040; CSF2; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000773; GM_colony-stim-fac.
DR   PANTHER; PTHR10059; PTHR10059; 1.
DR   Pfam; PF01109; GM_CSF; 1.
DR   PRINTS; PR00693; GMCSFACTOR.
DR   SMART; SM00040; CSF2; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00702; GM_CSF; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000250"
FT   CHAIN           18..144
FT                   /note="Granulocyte-macrophage colony-stimulating factor"
FT                   /id="PRO_0000005864"
FT   CARBOHYD        22
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        24
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        27
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        44
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        71..113
FT                   /evidence="ECO:0000250"
FT   DISULFID        105..138
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   144 AA;  16505 MW;  42C5BF5F8235DA55 CRC64;
     MWLQNLLFLN TVVCSISAPT SSPSSVTRPW QHVDAMKEAL SLLNNSSEIT AVMNETVEVV
     SEMFDPEEPK CLQTHLKLYE QGLRGSLISL KEPLRMMANH YKQHCPLTPE TPCETQTITF
     KNFKEKLKDF LFNNPFDCWG PDQK