CSF2_SHEEP
ID CSF2_SHEEP Reviewed; 144 AA.
AC P28773;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Granulocyte-macrophage colony-stimulating factor;
DE Short=GM-CSF;
DE AltName: Full=Colony-stimulating factor;
DE Short=CSF;
DE Flags: Precursor;
GN Name=CSF2;
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1937025; DOI=10.1016/0378-1119(91)90163-6;
RA McInnes C.J., Haig M.C.K.;
RT "Cloning and expression of a cDNA encoding ovine granulocyte-macrophage
RT colony-stimulating factor.";
RL Gene 105:275-279(1991).
CC -!- FUNCTION: Cytokine that stimulates the growth and differentiation of
CC hematopoietic precursor cells from various lineages, including
CC granulocytes, macrophages, eosinophils and erythrocytes. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. The signaling GM-CSF receptor complex is a dodecamer
CC of two head-to-head hexamers of two alpha, two beta, and two ligand
CC subunits (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the GM-CSF family. {ECO:0000305}.
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DR EMBL; X53561; CAA37632.1; -; mRNA.
DR PIR; JH0469; JH0469.
DR RefSeq; NP_001009805.1; NM_001009805.1.
DR PDB; 5D22; X-ray; 1.99 A; A/B=18-144.
DR PDB; 5D28; X-ray; 2.85 A; B/C=18-144.
DR PDBsum; 5D22; -.
DR PDBsum; 5D28; -.
DR AlphaFoldDB; P28773; -.
DR SASBDB; P28773; -.
DR SMR; P28773; -.
DR STRING; 9940.ENSOARP00000016551; -.
DR Ensembl; ENSOART00000016787; ENSOARP00000016551; ENSOARG00000015430.
DR Ensembl; ENSOART00020000736; ENSOARP00020000580; ENSOARG00020000571.
DR GeneID; 443400; -.
DR KEGG; oas:443400; -.
DR CTD; 1437; -.
DR eggNOG; ENOG502TDUI; Eukaryota.
DR HOGENOM; CLU_152286_0_0_1; -.
DR OMA; VTRPWKH; -.
DR OrthoDB; 1412355at2759; -.
DR Proteomes; UP000002356; Chromosome 5.
DR Bgee; ENSOARG00000015430; Expressed in lung and 26 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0030526; C:granulocyte macrophage colony-stimulating factor receptor complex; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR GO; GO:0005129; F:granulocyte macrophage colony-stimulating factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEA:Ensembl.
DR GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
DR GO; GO:0038157; P:granulocyte-macrophage colony-stimulating factor signaling pathway; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR GO; GO:0030224; P:monocyte differentiation; IEA:Ensembl.
DR GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0030223; P:neutrophil differentiation; IEA:Ensembl.
DR GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
DR GO; GO:0070665; P:positive regulation of leukocyte proliferation; IEA:Ensembl.
DR GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
DR GO; GO:0071803; P:positive regulation of podosome assembly; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:0006468; P:protein phosphorylation; IEA:Ensembl.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR CDD; cd00040; CSF2; 1.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR000773; GM_colony-stim-fac.
DR PANTHER; PTHR10059; PTHR10059; 1.
DR Pfam; PF01109; GM_CSF; 1.
DR PRINTS; PR00693; GMCSFACTOR.
DR SMART; SM00040; CSF2; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00702; GM_CSF; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytokine; Disulfide bond; Glycoprotein; Growth factor;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000250"
FT CHAIN 18..144
FT /note="Granulocyte-macrophage colony-stimulating factor"
FT /id="PRO_0000005868"
FT CARBOHYD 24
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250"
FT CARBOHYD 27
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 71..113
FT /evidence="ECO:0000250"
FT DISULFID 105..138
FT /evidence="ECO:0000250"
FT HELIX 31..44
FT /evidence="ECO:0007829|PDB:5D22"
FT HELIX 50..53
FT /evidence="ECO:0007829|PDB:5D22"
FT STRAND 56..60
FT /evidence="ECO:0007829|PDB:5D22"
FT STRAND 66..68
FT /evidence="ECO:0007829|PDB:5D22"
FT HELIX 72..82
FT /evidence="ECO:0007829|PDB:5D22"
FT HELIX 85..90
FT /evidence="ECO:0007829|PDB:5D22"
FT HELIX 91..104
FT /evidence="ECO:0007829|PDB:5D22"
FT STRAND 115..119
FT /evidence="ECO:0007829|PDB:5D22"
FT HELIX 120..133
FT /evidence="ECO:0007829|PDB:5D22"
SQ SEQUENCE 144 AA; 16318 MW; ABAAC8733B580008 CRC64;
MWLQNLLLLG TVVCSFSAPT RQPSPVTRPW QHVDAIKEAL SLLNDSTDTA AVMDETVEVV
SEMFDSQEPT CLQTRLELYK QGLRGSLTSL TGSLTMMASH YKKHCPPTQE TSCETQIITF
KSFKENLKDF LFIIPFDCWE PVQK
