ID   CSF3_FELCA              Reviewed;         194 AA.
AC   O02708;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Granulocyte colony-stimulating factor;
DE            Short=G-CSF;
DE   Flags: Precursor; Fragment;
GN   Name=CSF3;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=European shorthair; TISSUE=Lung;
RX   PubMed=11497496; DOI=10.1006/cyto.2001.0910;
RA   Dunham S.P., Onions D.E.;
RT   "Isolation, nucleotide sequence and expression of a cDNA encoding feline
RT   granulocyte colony-stimulating factor.";
RL   Cytokine 14:347-351(2001).
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages. This CSF
CC       induces granulocytes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: O-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; Y08558; CAA69853.1; -; mRNA.
DR   PIR; T09255; T09255.
DR   AlphaFoldDB; O02708; -.
DR   SMR; O02708; -.
DR   STRING; 9685.ENSFCAP00000013908; -.
DR   eggNOG; ENOG502SCNA; Eukaryota.
DR   InParanoid; O02708; -.
DR   TreeFam; TF337698; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR040117; GCSF/MGF.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; PTHR10511; 1.
DR   Pfam; PF16647; GCSF; 1.
DR   PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          <1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..194
FT                   /note="Granulocyte colony-stimulating factor"
FT                   /id="PRO_0000015569"
FT   CARBOHYD        153
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..94
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   194 AA;  21154 MW;  F72B7AB3DAE7385E CRC64;
     KLMALQLLLW HSALWMVQEA TPLGPTSSLP QSFLLKCLEQ VRKVQADGTA LQERLCAAHK
     LCHPEELVLL GHALGIPQAP LSSCSSQALQ LTGCLRQLHS GLFLYQGLLQ ALAGISPELA
     PTLDMLQLDI TDFAINIWQQ MEDVGMAPAV PPTQGTMPTF TSAFQRRAGG TLVASNLQSF
     LEVAYRALRH FTKP