CSF3_MOUSE
ID CSF3_MOUSE Reviewed; 208 AA.
AC P09920;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Granulocyte colony-stimulating factor;
DE Short=G-CSF;
DE Flags: Precursor;
GN Name=Csf3; Synonyms=Csfg;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3489940; DOI=10.1073/pnas.83.20.7633;
RA Tsuchiya M., Asano S., Kaziro Y., Nagata S.;
RT "Isolation and characterization of the cDNA for murine granulocyte colony-
RT stimulating factor.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:7633-7637(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3494605; DOI=10.1111/j.1432-1033.1987.tb11187.x;
RA Tsuchiya M., Kaziro Y., Nagata S.;
RT "The chromosomal gene structure for murine granulocyte colony-stimulating
RT factor.";
RL Eur. J. Biochem. 165:7-12(1987).
RN [3]
RP PARTIAL PROTEIN SEQUENCE.
RX PubMed=3501294; DOI=10.1515/bchm3.1987.368.2.1327;
RA Simpson R.J., Nice E.C., Nicola N.A.;
RT "Structural studies on the murine granulocyte colony-stimulating factor.";
RL Biol. Chem. Hoppe-Seyler 368:1327-1331(1987).
CC -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC cytokines that act in hematopoiesis by controlling the production,
CC differentiation, and function of 2 related white cell populations of
CC the blood, the granulocytes and the monocytes-macrophages. This CSF
CC induces granulocytes.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: O-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR EMBL; M13926; AAA37672.1; -; mRNA.
DR EMBL; X05402; CAA28986.1; -; Genomic_DNA.
DR CCDS; CCDS25360.1; -.
DR PIR; A29536; A26496.
DR RefSeq; NP_034101.1; NM_009971.1.
DR AlphaFoldDB; P09920; -.
DR SMR; P09920; -.
DR DIP; DIP-6118N; -.
DR STRING; 10090.ENSMUSP00000037762; -.
DR GlyGen; P09920; 1 site.
DR PhosphoSitePlus; P09920; -.
DR PaxDb; P09920; -.
DR PRIDE; P09920; -.
DR Antibodypedia; 799; 1313 antibodies from 40 providers.
DR DNASU; 12985; -.
DR Ensembl; ENSMUST00000038886; ENSMUSP00000037762; ENSMUSG00000038067.
DR GeneID; 12985; -.
DR KEGG; mmu:12985; -.
DR UCSC; uc007lgy.1; mouse.
DR CTD; 1440; -.
DR MGI; MGI:1339751; Csf3.
DR VEuPathDB; HostDB:ENSMUSG00000038067; -.
DR eggNOG; ENOG502SCNA; Eukaryota.
DR GeneTree; ENSGT00390000017328; -.
DR HOGENOM; CLU_118367_0_0_1; -.
DR InParanoid; P09920; -.
DR OMA; HHQVGGF; -.
DR OrthoDB; 1289639at2759; -.
DR PhylomeDB; P09920; -.
DR TreeFam; TF337698; -.
DR Reactome; R-MMU-449836; Other interleukin signaling.
DR Reactome; R-MMU-9674555; Signaling by CSF3 (G-CSF).
DR Reactome; R-MMU-9705462; Inactivation of CSF3 (G-CSF) signaling.
DR BioGRID-ORCS; 12985; 4 hits in 75 CRISPR screens.
DR PRO; PR:P09920; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P09920; protein.
DR Bgee; ENSMUSG00000038067; Expressed in entorhinal cortex and 12 other tissues.
DR ExpressionAtlas; P09920; baseline and differential.
DR Genevisible; P09920; MM.
DR GO; GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IPI:MGI.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; ISO:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0030851; P:granulocyte differentiation; NAS:UniProtKB.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
DR GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISO:MGI.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IGI:MGI.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISO:MGI.
DR GO; GO:0032092; P:positive regulation of protein binding; ISO:MGI.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR040117; GCSF/MGF.
DR InterPro; IPR030474; IL-6/GCSF/MGF.
DR InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR PANTHER; PTHR10511; PTHR10511; 1.
DR Pfam; PF16647; GCSF; 1.
DR PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
DR PRINTS; PR00433; IL6GCSFMGF.
DR SMART; SM00126; IL6; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00254; INTERLEUKIN_6; 1.
PE 1: Evidence at protein level;
KW Cytokine; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT CHAIN 31..208
FT /note="Granulocyte colony-stimulating factor"
FT /id="PRO_0000015571"
FT CARBOHYD 169
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250"
FT DISULFID 72..78
FT /evidence="ECO:0000250"
FT DISULFID 100..110
FT /evidence="ECO:0000250"
SQ SEQUENCE 208 AA; 22421 MW; 0BF3622135C906DB CRC64;
MAQLSAQRRM KLMALQLLLW QSALWSGREA VPLVTVSALP PSLPLPRSFL LKSLEQVRKI
QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC SSQALQQTQC LSQLHSGLCL
YQGLLQALSG ISPALAPTLD LLQLDVANFA TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF
QRRAGGVLAI SYLQGFLETA RLALHHLA
