ID   CSF3_PIG                Reviewed;         195 AA.
AC   O02837; O19180;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Granulocyte colony-stimulating factor;
DE            Short=G-CSF;
DE   Flags: Precursor;
GN   Name=CSF3;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9332386; DOI=10.1016/s0378-1119(97)00284-9;
RA   Kulmburg P., Radke M., Mezes B., Mertelsmann R., Rosenthal F.M.;
RT   "Cloning and sequence analysis of the immediate promoter region and cDNA of
RT   porcine granulocyte colony-stimulating factor.";
RL   Gene 197:361-365(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Liver;
RA   Gloster S.E., Sandeman R.M., Strom A.D.G.;
RT   "Cloning of a cDNA and gene encoding porcine granulocyte-colony stimulating
RT   factor.";
RL   Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages. This CSF
CC       induces granulocytes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: O-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; Y10494; CAA71518.1; -; mRNA.
DR   EMBL; U68482; AAB70701.1; -; Genomic_DNA.
DR   EMBL; U68481; AAB70700.1; -; mRNA.
DR   RefSeq; NP_999007.1; NM_213842.1.
DR   RefSeq; XP_005653977.1; XM_005653920.2.
DR   AlphaFoldDB; O02837; -.
DR   SMR; O02837; -.
DR   STRING; 9823.ENSSSCP00000018529; -.
DR   PaxDb; O02837; -.
DR   Ensembl; ENSSSCT00005005326; ENSSSCP00005003047; ENSSSCG00005003527.
DR   Ensembl; ENSSSCT00015019785; ENSSSCP00015007769; ENSSSCG00015014893.
DR   Ensembl; ENSSSCT00065008751; ENSSSCP00065003693; ENSSSCG00065006472.
DR   GeneID; 396839; -.
DR   KEGG; ssc:396839; -.
DR   CTD; 1440; -.
DR   eggNOG; ENOG502SCNA; Eukaryota.
DR   HOGENOM; CLU_118367_0_0_1; -.
DR   InParanoid; O02837; -.
DR   OMA; HHQVGGF; -.
DR   OrthoDB; 1289639at2759; -.
DR   TreeFam; TF337698; -.
DR   Reactome; R-SSC-449836; Other interleukin signaling.
DR   Reactome; R-SSC-9674555; Signaling by CSF3 (G-CSF).
DR   Reactome; R-SSC-9705462; Inactivation of CSF3 (G-CSF) signaling.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; O02837; SS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IBA:GO_Central.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR040117; GCSF/MGF.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; PTHR10511; 1.
DR   Pfam; PF16647; GCSF; 1.
DR   PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..195
FT                   /note="Granulocyte colony-stimulating factor"
FT                   /id="PRO_0000015572"
FT   CARBOHYD        154
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..95
FT                   /evidence="ECO:0000250"
FT   CONFLICT        123
FT                   /note="A -> R (in Ref. 1; CAA71518)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   195 AA;  21214 MW;  84787F20DB0AEA1C CRC64;
     MKLMALQLLL WHIALWMVPE AAPLSPASSL PQSFLLKCLE QVRKIQADGA ELQERLCATH
     KLCHPQELVL LGHSLGLPQA SLSSCSSQAL QLTGCLNQLH GGLVLYQGLL QALAGISPEL
     APALDILQLD VTDLATNIWL QMEDLRMAPA SLPTQGTVPT FTSAFQRRAG GVLVVSQLQS
     FLELAYRVLR YLAEP