ID   CSF3_SHEEP              Reviewed;         174 AA.
AC   Q28746;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Granulocyte colony-stimulating factor;
DE            Short=G-CSF;
GN   Name=CSF3;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7528579; DOI=10.3109/10425179409020862;
RA   O'Brien P.M., Seow H.F., Rothel J.S., Wood P.R.;
RT   "Cloning and sequencing of an ovine granulocyte colony-stimulating factor
RT   cDNA.";
RL   DNA Seq. 4:339-342(1994).
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages. This CSF
CC       induces granulocytes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: O-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; L07939; AAA68006.1; -; mRNA.
DR   PIR; T10268; T10268.
DR   AlphaFoldDB; Q28746; -.
DR   SMR; Q28746; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR040117; GCSF/MGF.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; PTHR10511; 1.
DR   Pfam; PF16647; GCSF; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Growth factor; Reference proteome;
KW   Secreted.
FT   CHAIN           1..174
FT                   /note="Granulocyte colony-stimulating factor"
FT                   /id="PRO_0000058760"
FT   CARBOHYD        133
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..42
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..74
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   174 AA;  18806 MW;  BA5AA8F8D23ACD1E CRC64;
     TPLGPARSLP QSFLLKCLEQ VRKIQADGAE LQERLCATHK LCHPEELVLL GHSLGIPQAP
     LSSCSSQSLQ LTSCLDQLHG GLFLYQGLLQ ALAGISPELA PTLDTLQLDV TDFATNIWLQ
     MEDLGVAPAV QPTQGTMPTF TSAFQRRAGG VLVASQLQRF LGLAYRGLRY LAEP