ID   CSGA_ECO57              Reviewed;         152 AA.
AC   Q93U24;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Major curlin subunit;
DE   Flags: Precursor;
GN   Name=csgA; OrderedLocusNames=Z1676, ECs1420;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=O157:H7 / ATCC 43895 / CDC EDL 933 / EHEC;
RX   PubMed=11319125; DOI=10.1128/aem.67.5.2367-2370.2001;
RA   Uhlich G.A., Keen J.E., Elder R.O.;
RT   "Mutations in the csgD promoter associated with variations in curli
RT   expression in certain strains of Escherichia coli O157:H7.";
RL   Appl. Environ. Microbiol. 67:2367-2370(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Curlin is the structural subunit of the curli. Curli are
CC       coiled surface structures that assemble preferentially at growth
CC       temperatures below 37 degrees Celsius. Curli can bind to fibronectin.
CC   -!- SUBCELLULAR LOCATION: Fimbrium. Note=Part of the curli surface
CC       structure.
CC   -!- SIMILARITY: Belongs to the CsgA/CsgB family. {ECO:0000305}.
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DR   EMBL; AF275733; AAK53212.1; -; Genomic_DNA.
DR   EMBL; AE005174; AAG55788.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34843.1; -; Genomic_DNA.
DR   PIR; D90806; D90806.
DR   PIR; H85665; H85665.
DR   RefSeq; NP_309447.1; NC_002695.1.
DR   RefSeq; WP_000771428.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q93U24; -.
DR   STRING; 155864.EDL933_1617; -.
DR   EnsemblBacteria; AAG55788; AAG55788; Z1676.
DR   EnsemblBacteria; BAB34843; BAB34843; ECs_1420.
DR   GeneID; 913991; -.
DR   KEGG; ece:Z1676; -.
DR   KEGG; ecs:ECs_1420; -.
DR   PATRIC; fig|386585.9.peg.1521; -.
DR   eggNOG; ENOG5030M63; Bacteria.
DR   HOGENOM; CLU_1861613_0_0_6; -.
DR   OMA; NSEIQIY; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   InterPro; IPR009742; Curlin_rpt.
DR   Pfam; PF07012; Curlin_rpt; 3.
PE   3: Inferred from homology;
KW   Fimbrium; Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..152
FT                   /note="Major curlin subunit"
FT                   /id="PRO_0000006370"
SQ   SEQUENCE   152 AA;  15099 MW;  EE2D2D94DDE91243 CRC64;
     MKLLKVAAIA AIVFSGSALA GVVPQYGGGG GNHGGGGNNS GPNSELNIYQ YGGGNSALAL
     QADARNSDLT ITQHGGGNGA DVGQGSDDSS IDLTQRGFGN SATLDQWNGK DSHMTVKQFG
     GGNGAAVDQT ASNSTVNVTQ VGFGNNATAH QY