ID   CSGA_MYXXA              Reviewed;         166 AA.
AC   P21158;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=C-factor;
DE   AltName: Full=C signal;
GN   Name=csgA; Synonyms=spoC;
OS   Myxococcus xanthus.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Myxococcaceae; Myxococcus.
OX   NCBI_TaxID=34;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2152896; DOI=10.1128/jb.172.1.15-23.1990;
RA   Hagen T.J., Shimkets L.J.;
RT   "Nucleotide sequence and transcriptional products of the csg locus of
RT   Myxococcus xanthus.";
RL   J. Bacteriol. 172:15-23(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 93-102, AND FUNCTION.
RX   PubMed=2107980; DOI=10.1016/0092-8674(90)90211-v;
RA   Kin S.K., Kaiser D.;
RT   "C-factor: a cell-cell signaling protein required for fruiting body
RT   morphogenesis of M. xanthus.";
RL   Cell 61:19-26(1990).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=2118510; DOI=10.1128/jb.172.9.5299-5306.1990;
RA   Shimkets L.J., Rafiee H.;
RT   "CsgA, an extracellular protein essential for Myxococcus xanthus
RT   development.";
RL   J. Bacteriol. 172:5299-5306(1990).
RN   [4]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=1372277; DOI=10.1101/gad.6.3.401;
RA   Li S., Lee B.U., Shimkets L.J.;
RT   "csgA expression entrains Myxococcus xanthus development.";
RL   Genes Dev. 6:401-410(1992).
CC   -!- FUNCTION: Cell-cell signaling protein required for fruiting body
CC       morphogenesis. Necessary for cellular aggregation, for spore
CC       differentiation, and for gene expression that is initiated after 6 hour
CC       of starvation. {ECO:0000269|PubMed:2107980,
CC       ECO:0000269|PubMed:2118510}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2118510}.
CC   -!- DEVELOPMENTAL STAGE: Increases throughout development, reaching its
CC       peak during sporulation. {ECO:0000269|PubMed:1372277}.
CC   -!- SIMILARITY: To yeast YKL071W. {ECO:0000305}.
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DR   EMBL; L27429; AAA25391.1; -; Genomic_DNA.
DR   PIR; T10125; T10125.
DR   RefSeq; WP_011551411.1; NZ_JABFNQ010000064.1.
DR   AlphaFoldDB; P21158; -.
DR   SMR; P21158; -.
DR   GeneID; 41358740; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Sporulation.
FT   CHAIN           1..166
FT                   /note="C-factor"
FT                   /id="PRO_0000079394"
SQ   SEQUENCE   166 AA;  17741 MW;  E1989BDB197ADCAD CRC64;
     MRAFATNVCT GPVDVLINNA GVSGLWCALG DVDYADMART FTINALGPLR VTSAMLPGLR
     QGALRRVAHV TSRMGSLAAN TDGGAYAYRM SKAALNMAVR SMSTDLRPEG FVTVLLHPGW
     VQTDMGGPDA TLPAPDSVRG MLRVIDGLNP EHSGRFFDYQ GTEVPW