CSGC_ECOLI
ID CSGC_ECOLI Reviewed; 110 AA.
AC P52107;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Curli assembly protein CsgC;
DE Flags: Precursor;
GN Name=csgC; OrderedLocusNames=b1043, JW1026;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574;
RX PubMed=8817489; DOI=10.1111/j.1365-2958.1995.mmi_18040661.x.;
RA Hammar M., Arnqvist A., Bian Z., Olsen A., Normark S.;
RT "Expression of two csg operons is required for production of
RT fibronectin- and congo red-binding curli polymers in Escherichia coli K-
RT 12.";
RL Mol. Microbiol. 18:661-670(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP INDUCTION.
RC STRAIN=K12 / MC4100;
RX PubMed=17010156; DOI=10.1111/j.1365-2958.2006.05440.x;
RA Weber H., Pesavento C., Possling A., Tischendorf G., Hengge R.;
RT "Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia
RT coli.";
RL Mol. Microbiol. 62:1014-1034(2006).
CC -!- FUNCTION: Plays a role in the extracellular assembly of CsgA into thin
CC aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE.
CC Tafi are thought to be assembled via an extracellular nucleation-
CC precipitation (ENP) pathway, and possibly also via an intracellular
CC non-CsgC-dependent pathway (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC -!- INDUCTION: Under control of the CsgD transcription factor, part of the
CC csgBAC/ymdA operon. {ECO:0000269|PubMed:17010156}.
CC -!- SIMILARITY: Belongs to the CsgC/AgfC family. {ECO:0000305}.
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DR EMBL; X90754; CAA62283.1; -; Genomic_DNA.
DR EMBL; U00096; AAC74127.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA35833.1; -; Genomic_DNA.
DR PIR; S70789; S70789.
DR RefSeq; NP_415561.1; NC_000913.3.
DR RefSeq; WP_001094300.1; NZ_SSZK01000058.1.
DR AlphaFoldDB; P52107; -.
DR SMR; P52107; -.
DR STRING; 511145.b1043; -.
DR PaxDb; P52107; -.
DR PRIDE; P52107; -.
DR EnsemblBacteria; AAC74127; AAC74127; b1043.
DR EnsemblBacteria; BAA35833; BAA35833; BAA35833.
DR GeneID; 945623; -.
DR KEGG; ecj:JW1026; -.
DR KEGG; eco:b1043; -.
DR PATRIC; fig|1411691.4.peg.1226; -.
DR EchoBASE; EB3190; -.
DR eggNOG; ENOG5032UJP; Bacteria.
DR HOGENOM; CLU_152585_0_0_6; -.
DR OMA; SNQLWFD; -.
DR PhylomeDB; P52107; -.
DR BioCyc; EcoCyc:G6548-MON; -.
DR PRO; PR:P52107; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR InterPro; IPR014491; Curli_production_prot_CsgC.
DR Pfam; PF10610; Tafi-CsgC; 1.
DR PIRSF; PIRSF018100; CsgC; 1.
PE 2: Evidence at transcript level;
KW Chaperone; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..8
FT /evidence="ECO:0000255"
FT CHAIN 9..110
FT /note="Curli assembly protein CsgC"
FT /id="PRO_0000021013"
SQ SEQUENCE 110 AA; 11967 MW; FD84CFB9C082CEE8 CRC64;
MNTLLLLAAL SSQITFNTTQ QGDVYTIIPE VTLTQSCLCR VQILSLREGS SGQSQTKQEK
TLSLPANQPI ALTKLSLNIS PDDRVKIVVT VSDGQSLHLS QQWPPSSEKS
