ID   CSGC_SALEN              Reviewed;         108 AA.
AC   P0A1Z9; P55227;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Curli assembly protein CsgC;
DE   Flags: Precursor;
GN   Name=csgC; Synonyms=agfC, orfC;
OS   Salmonella enteritidis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=149539;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=27655-3B;
RX   PubMed=8550497; DOI=10.1128/jb.178.3.662-667.1996;
RA   Collinson S.K., Clouthier S.C., Doran J.L., Banser P.A., Kay W.W.;
RT   "Salmonella enteritidis agfBAC operon encoding thin, aggregative
RT   fimbriae.";
RL   J. Bacteriol. 178:662-667(1996).
RN   [2]
RP   PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION IN THIN AGGREGATIVE FIMBRIAE
RP   ASSEMBLY, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, INDUCTION, AND OPERON
RP   STRUCTURE.
RC   STRAIN=27655-3B;
RX   PubMed=17379722; DOI=10.1099/mic.0.2006/000935-0;
RA   Gibson D.L., White A.P., Rajotte C.M., Kay W.W.;
RT   "AgfC and AgfE facilitate extracellular thin aggregative fimbriae synthesis
RT   in Salmonella enteritidis.";
RL   Microbiology 153:1131-1140(2007).
CC   -!- FUNCTION: Plays a role in the extracellular assembly of CsgA (also
CC       known as AgfA, AC P0A1E7) into thin aggregative fimbriae (Tafi) fibers.
CC       Assembly may also require CsgE (AgfE). Tafi are thought to be assembled
CC       via an extracellular nucleation-precipitation (ENP) pathway, and
CC       possibly also via an intracellular non-CsgC-dependent pathway.
CC       {ECO:0000269|PubMed:17379722}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:17379722}.
CC       Note=Upon overexpression; a small amount is also seen in the cytoplasm.
CC   -!- INDUCTION: Expressed at low levels in agar-grown cells, part of the
CC       csgBAC (agfBAC) operon. {ECO:0000269|PubMed:17379722}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene make aberrant thin
CC       aggregative fimbriae (Tafi) which are composed solely of CsgA. Normal
CC       Tafi are composed of CsgA and CsgB at a 20:1 ration.
CC       {ECO:0000269|PubMed:17379722}.
CC   -!- SIMILARITY: Belongs to the CsgC/AgfC family. {ECO:0000305}.
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DR   EMBL; U43280; AAC43600.1; -; Genomic_DNA.
DR   PIR; JC6041; JC6041.
DR   RefSeq; WP_000557256.1; NZ_WIAP01000025.1.
DR   AlphaFoldDB; P0A1Z9; -.
DR   SMR; P0A1Z9; -.
DR   PATRIC; fig|149539.321.peg.2068; -.
DR   OMA; SNQLWFD; -.
DR   GO; GO:0042597; C:periplasmic space; IDA:UniProtKB.
DR   GO; GO:0009297; P:pilus assembly; IMP:UniProtKB.
DR   InterPro; IPR014491; Curli_production_prot_CsgC.
DR   Pfam; PF10610; Tafi-CsgC; 1.
DR   PIRSF; PIRSF018100; CsgC; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Direct protein sequencing; Periplasm; Signal.
FT   SIGNAL          1..8
FT                   /evidence="ECO:0000305|PubMed:17379722"
FT   CHAIN           9..108
FT                   /note="Curli assembly protein CsgC"
FT                   /id="PRO_0000021014"
SQ   SEQUENCE   108 AA;  11721 MW;  EF8EC3B795F4C05E CRC64;
     MHTLLLLAAL SNQITFTTTQ QGDIYTVIPQ VTLNEPCVCQ VQILSVRDGV GGQSHTQQKQ
     TLSLPANQPI ELSRLSVNIS SEDSVKIIVT VSDGQSLHLS QQWPPSAQ