ID   CSG_METSC               Reviewed;         593 AA.
AC   P27374;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Cell surface glycoprotein;
DE   AltName: Full=S-layer protein;
DE   Flags: Precursor;
GN   Name=slgA;
OS   Methanothermus sociabilis.
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanothermaceae; Methanothermus.
OX   NCBI_TaxID=2181;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 3496 / JCM 10723 / OCM 173 / KF1-FL;
RX   PubMed=1712296; DOI=10.1111/j.1432-1033.1991.tb16102.x;
RA   Broeckl G., Behr M., Fabry S., Hensel R., Kaudewitz H., Biendl E.,
RA   Koenig H.;
RT   "Analysis and nucleotide sequence of the genes encoding the surface-layer
RT   glycoproteins of the hyperthermophilic methanogens Methanothermus fervidus
RT   and Methanothermus sociabilis.";
RL   Eur. J. Biochem. 199:147-152(1991).
CC   -!- SUBUNIT: Assemble into mono-layered crystalline arrays.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall, S-layer.
CC   -!- PTM: Glycosylated.
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DR   EMBL; X58296; CAA41229.1; -; Genomic_DNA.
DR   PIR; S16375; S16375.
DR   AlphaFoldDB; P27374; -.
DR   SMR; P27374; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030115; C:S-layer; IEA:UniProtKB-SubCell.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.160.20.10; -; 1.
DR   InterPro; IPR006633; Carb-bd_sugar_hydrolysis-dom.
DR   InterPro; IPR007742; NosD_dom.
DR   InterPro; IPR022441; Para_beta_helix_rpt-2.
DR   InterPro; IPR006626; PbH1.
DR   InterPro; IPR012334; Pectin_lyas_fold.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   Pfam; PF05048; NosD; 2.
DR   SMART; SM00722; CASH; 2.
DR   SMART; SM00710; PbH1; 8.
DR   SUPFAM; SSF51126; SSF51126; 1.
DR   TIGRFAMs; TIGR03804; para_beta_helix; 1.
PE   3: Inferred from homology;
KW   Cell wall; Cell wall biogenesis/degradation; Glycoprotein; S-layer;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..593
FT                   /note="Cell surface glycoprotein"
FT                   /id="PRO_0000032619"
FT   CARBOHYD        29
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        58
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        66
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        74
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        122
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        145
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        148
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        158
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        208
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        231
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        326
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        336
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        340
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        431
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        471
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        500
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        516
FT                   /note="N-linked (GalNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   593 AA;  65503 MW;  DFCDFB357E10F2EB CRC64;
     MRKFTLLMLL LIVISMSGIA GAAEVKNLNT SKTFTKIQEA IDDPSTTDGN IIIVGPGNYT
     ENILVNKSLT LKSNGSAIIN AVSSEKSTIT IKANNVWIEG FIIIGGKNGI YMENVTGCTI
     TNNTIQNAFV SGWEYYGGNG ICLVNSTNNT ITNNIIRNNT WNGINVCESK GNIIKNNTIM
     YSGGIGIYVW GFNKFEGNNI IENNRIINAT YGGIYLFRPS NNKICRNYIA NVSSGGGGMS
     GAICIDVSDY NIVKDNIGVN CDGGLFTDGM IGNEITNNIF KNCKVAVSES TYGPASRNNK
     IYGNYFINYE TAISDPKGEL VDNIWNTTEG GNYWSNYTGN NTGDGTGNIP YYYDNKPLVV
     DLAIEDIAAK PSGIEVRVKN LGKADIKKID PLTKLKIKIS CDNDVYETFI DPLSAGESQI
     VRWDKIVPEG NHTIKAEIPY SAEGYLIGTN IRDADISNNV FSKMVQGFVQ NKTFTITLTN
     LGKSTITIKY YISIYTNPVN GTKVSYRELT ITLKPNETKT IELGKYPFKY AVSGTMIVKN
     PSRYRIPLNL RIKYEIEGLN PQMREISKYM APRGEFRYIA RYTGKEEGYA DVW