CSH1_BOVIN
ID CSH1_BOVIN Reviewed; 236 AA.
AC P09611;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Chorionic somatomammotropin hormone 1;
DE AltName: Full=BPLP-I;
DE AltName: Full=Placental lactogen I;
DE Flags: Precursor;
GN Name=CSH1; Synonyms=PL1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2341410; DOI=10.1016/s0021-9258(19)38975-6;
RA Yamakawa M., Tanaka M., Koyama M., Kagesato Y., Watahiki M., Yamamoto M.,
RA Nakashima K.;
RT "Expression of new members of the prolactin growth hormone gene family in
RT bovine placenta. Isolation and characterization of two prolactin-like cDNA
RT clones.";
RL J. Biol. Chem. 265:8915-8920(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=3242594; DOI=10.1021/bi00422a022;
RA Schuler L.A., Shimomura K., Kessler M.A., Zieler C.G., Bremel R.D.;
RT "Bovine placental lactogen: molecular cloning and protein structure.";
RL Biochemistry 27:8443-8448(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=2003877; DOI=10.1089/dna.1991.10.93;
RA Kessler M.A., Schuler L.A.;
RT "Structure of the bovine placental lactogen gene and alternative splicing
RT of transcripts.";
RL DNA Cell Biol. 10:93-104(1991).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; J02840; AAA30709.1; -; mRNA.
DR EMBL; M33268; AAA30739.1; -; mRNA.
DR EMBL; M65218; AAA30612.1; ALT_SEQ; mRNA.
DR EMBL; M65219; AAA30613.1; ALT_SEQ; mRNA.
DR EMBL; M65224; AAA30611.1; -; Genomic_DNA.
DR EMBL; M65220; AAA30611.1; JOINED; Genomic_DNA.
DR EMBL; M65221; AAA30611.1; JOINED; Genomic_DNA.
DR EMBL; M65222; AAA30611.1; JOINED; Genomic_DNA.
DR EMBL; M65223; AAA30611.1; JOINED; Genomic_DNA.
DR PIR; A37930; A37930.
DR AlphaFoldDB; P09611; -.
DR SMR; P09611; -.
DR STRING; 9913.ENSBTAP00000035394; -.
DR PaxDb; P09611; -.
DR PRIDE; P09611; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR InParanoid; P09611; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:0009893; P:positive regulation of metabolic process; IEA:UniProt.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..36
FT CHAIN 37..236
FT /note="Chorionic somatomammotropin hormone 1"
FT /id="PRO_0000032956"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 98..214
FT /evidence="ECO:0000250"
FT DISULFID 231..236
FT /evidence="ECO:0000250"
FT CONFLICT 37
FT /note="V -> A (in Ref. 2; AAA30709)"
FT /evidence="ECO:0000305"
FT CONFLICT 94
FT /note="V -> F (in Ref. 2; AAA30709 and 3; AAA30611)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="V -> M (in Ref. 3; AAA30613)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 236 AA; 26909 MW; 2C46637D8C9D7471 CRC64;
MAPASSHRGH QWICDLVRGS CLLLLLVVSN LLLCQGVEDY APYCKNQPGN CRIPLQSLFE
RATLVASNNY RLAREMFNEF NKQFGEGKNF TSKVINSCHT EFMTTPNNKE AAANTEDEAL
LRLVISLLHS WDEPLHQAVT ELLHRNGASP DILARAKEIE DKTKVLLEGV EMIQKRVHPG
EKKNEPYPVW SEKSSLTADD EDVRQTAFYR MFHCLHRDSS KISTYINLLK CRFTPC
