CSH2_BOVIN
ID CSH2_BOVIN Reviewed; 238 AA.
AC P19159;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Chorionic somatomammotropin hormone 2;
DE AltName: Full=BPLP-II;
DE AltName: Full=Placental lactogen II;
DE Flags: Precursor;
GN Name=CSH2; Synonyms=PL2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2341410; DOI=10.1016/s0021-9258(19)38975-6;
RA Yamakawa M., Tanaka M., Koyama M., Kagesato Y., Watahiki M., Yamamoto M.,
RA Nakashima K.;
RT "Expression of new members of the prolactin growth hormone gene family in
RT bovine placenta. Isolation and characterization of two prolactin-like cDNA
RT clones.";
RL J. Biol. Chem. 265:8915-8920(1990).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC {ECO:0000305}.
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DR EMBL; M33269; AAA30740.1; -; mRNA.
DR PIR; B36284; B36284.
DR AlphaFoldDB; P19159; -.
DR SMR; P19159; -.
DR PaxDb; P19159; -.
DR eggNOG; ENOG502QYU3; Eukaryota.
DR InParanoid; P19159; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005148; F:prolactin receptor binding; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0030879; P:mammary gland development; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:1903489; P:positive regulation of lactation; IBA:GO_Central.
DR GO; GO:0009893; P:positive regulation of metabolic process; IEA:UniProt.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0031667; P:response to nutrient levels; IBA:GO_Central.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001400; Somatotropin/Prolactin.
DR InterPro; IPR018116; Somatotropin_CS.
DR PANTHER; PTHR11417; PTHR11417; 1.
DR Pfam; PF00103; Hormone_1; 1.
DR PRINTS; PR00836; SOMATOTROPIN.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Metal-binding; Reference proteome;
KW Secreted; Signal; Zinc.
FT SIGNAL 1..36
FT CHAIN 37..238
FT /note="Chorionic somatomammotropin hormone 2"
FT /id="PRO_0000032957"
FT BINDING 66
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 224
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..215
FT /evidence="ECO:0000250"
FT DISULFID 232..238
FT /evidence="ECO:0000250"
SQ SEQUENCE 238 AA; 27714 MW; 3ECA89E290760242 CRC64;
MAPAPSFRGH QWTYNPVRGS CLLLLLVVSN LLLCQGISCP SCGPDMFVSL QKSLIDVFIN
AASLSHDFHN LSTIMFNEFD EKYAQGKLYY INATKSCHTN SFHTPEERDK AQQMNNEDLS
KWTLVLLYSW NNPLYYLLLE LRNMKNLSEA VISSAMEIEN MSEKLQAFIE SQFRKIIVPV
LKMIHEVSDT WSRFSSMTFS DEDRSISEYY NLFYCLRRDS RKVDMYIKIL TCRTRKTC
