ID   ACPX_STRGA              Reviewed;          83 AA.
AC   P12884;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Tetracenomycin C polyketide synthase acyl carrier protein;
DE            Short=ACP;
GN   Name=tcmM;
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 40716 / ETH 22794 / Tue 49;
RX   PubMed=2684656; DOI=10.1002/j.1460-2075.1989.tb08414.x;
RA   Bibb M.J., Biro S., Motamedi H., Collins J.F., Hutchinson C.R.;
RT   "Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI
RT   genes provides key information about the enzymology of polyketide
RT   antibiotic biosynthesis.";
RL   EMBO J. 8:2727-2736(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-83.
RX   PubMed=1548230; DOI=10.1128/jb.174.6.1810-1820.1992;
RA   Summers R.G., Wendt-Pienkowski E., Motamedi H., Hutchinson C.R.;
RT   "Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C
RT   biosynthetic gene cluster of Streptomyces glaucescens and evidence that the
RT   tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl
RT   transferase.";
RL   J. Bacteriol. 174:1810-1820(1992).
CC   -!- FUNCTION: Acyl carrier protein.
CC   -!- PATHWAY: Antibiotic biosynthesis; tetracenomycin C biosynthesis.
CC   -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific serine
CC       of the apo-ACP-like protein. {ECO:0000305}.
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DR   EMBL; X15312; CAB38456.1; -; Genomic_DNA.
DR   EMBL; M80674; AAA67517.1; -; Genomic_DNA.
DR   PIR; S05975; S05975.
DR   RefSeq; WP_043504919.1; NZ_CP009438.1.
DR   AlphaFoldDB; P12884; -.
DR   SMR; P12884; -.
DR   STRING; 1907.SGLAU_26365; -.
DR   eggNOG; COG0236; Bacteria.
DR   OrthoDB; 1943389at2; -.
DR   BioCyc; MetaCyc:MON-18612; -.
DR   UniPathway; UPA00174; -.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Phosphopantetheine; Phosphoprotein.
FT   CHAIN           1..83
FT                   /note="Tetracenomycin C polyketide synthase acyl carrier
FT                   protein"
FT                   /id="PRO_0000180252"
FT   DOMAIN          3..83
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         41
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   83 AA;  9083 MW;  E1BD26C99786D652 CRC64;
     MPQIGLPRLV EIIRECAGDP DERDLDGDIL DVTYQDLGYD SIALLEISAK LEQDLGVSIP
     GEELKTPRHT LHLVNTETAG EVA