ID   CSH_SHEEP               Reviewed;         236 AA.
AC   P16038; Q7M2L2;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Chorionic somatomammotropin hormone;
DE   AltName: Full=Placental lactogen;
DE            Short=PL;
DE   Flags: Precursor;
GN   Name=CSH;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2608069; DOI=10.1210/mend-3-9-1462;
RA   Colosi P., Thordarson G., Hellmiss R., Singh K., Forsyth I.A., Gluckman P.,
RA   Wood W.I.;
RT   "Cloning and expression of ovine placental lactogen.";
RL   Mol. Endocrinol. 3:1462-1469(1989).
RN   [2]
RP   PROTEIN SEQUENCE OF 62-73; 80-87; 182-191; 204-208 AND 220-227.
RX   PubMed=8639711; DOI=10.1016/0167-4838(95)00260-x;
RA   Cymes G.D., Wolfenstein-Todel C.;
RT   "Identification of a tyrosine residue in ovine placental lactogen as
RT   essential for its binding to receptors.";
RL   Biochim. Biophys. Acta 1294:31-36(1996).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 44-234.
RX   PubMed=10966654; DOI=10.1038/79047;
RA   Elkins P.A., Christinger H.W., Sandowski Y., Sakal E., Gertler A.,
RA   de Vos A.M., Kossiakoff A.A.;
RT   "Ternary complex between placental lactogen and the extracellular domain of
RT   the prolactin receptor.";
RL   Nat. Struct. Biol. 7:808-815(2000).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000305}.
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DR   EMBL; M31660; AAA31577.1; -; mRNA.
DR   PIR; A40143; A40143.
DR   PIR; S70031; S70031.
DR   RefSeq; NP_001009309.2; NM_001009309.3.
DR   PDB; 1F6F; X-ray; 2.30 A; A=38-236.
DR   PDBsum; 1F6F; -.
DR   AlphaFoldDB; P16038; -.
DR   SMR; P16038; -.
DR   MINT; P16038; -.
DR   STRING; 9940.ENSOARP00000009523; -.
DR   Ensembl; ENSOART00020024258; ENSOARP00020020112; ENSOARG00020015814.
DR   GeneID; 443319; -.
DR   KEGG; oas:443319; -.
DR   eggNOG; ENOG502QYU3; Eukaryota.
DR   OrthoDB; 1290070at2759; -.
DR   EvolutionaryTrace; P16038; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005148; F:prolactin receptor binding; IDA:AgBase.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..236
FT                   /note="Chorionic somatomammotropin hormone"
FT                   /id="PRO_0000032966"
FT   DISULFID        44..51
FT   DISULFID        97..212
FT   DISULFID        229..234
FT   HELIX           42..44
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   STRAND          46..50
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   HELIX           55..81
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   HELIX           98..101
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   HELIX           108..113
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   HELIX           116..128
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   HELIX           131..142
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   HELIX           150..176
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   HELIX           189..195
FT                   /evidence="ECO:0007829|PDB:1F6F"
FT   HELIX           199..231
FT                   /evidence="ECO:0007829|PDB:1F6F"
SQ   SEQUENCE   236 AA;  26695 MW;  E6223AFE2FF9BB35 CRC64;
     MAPASSHREH QWTCNLVRGS RLLLLLVVSN LILCQGQAQH PPYCRNQPGK CQIPLQSLFD
     RATTVANYNS KLAGEMVNRF DEQYGQGINS ESKVINCHTS SITTPNSKAE AINTEDKILF
     KLVISLLHSW DEPLHHAVTE LANSKGTSPA LLTKAQEIKE KAKVLVDGVE VIQKRIHPGE
     KNEPYPVWSE QSSLTSQDEN VRRVAFYRLF HCLHRDSSKI YTYLRILKCR LTSCET