ID   ACPX_STRRM              Reviewed;          95 AA.
AC   P43677;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Oxytetracycline polyketide synthase acyl carrier protein;
DE            Short=ACP;
OS   Streptomyces rimosus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1927;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8163168; DOI=10.1016/0378-1119(94)90144-9;
RA   Kim E.S., Bibb M.J., Butler M.J., Hopwood D.A., Sherman D.H.;
RT   "Sequences of the oxytetracycline polyketide synthase-encoding otc genes
RT   from Streptomyces rimosus.";
RL   Gene 141:141-142(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=15883;
RA   Linton K.J., Hunter I.S.;
RT   "The acyl-carrier protein for biosynthesis of oxytetracycline from
RT   Streptomyces rimosus: overexpression in Escherichia coli, purification and
RT   characterization of the apoprotein.";
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acyl carrier protein.
CC   -!- PATHWAY: Antibiotic biosynthesis; oxytetracycline biosynthesis.
CC   -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific serine
CC       of the apo-ACP-like protein. {ECO:0000305}.
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DR   EMBL; Z25538; CAA80986.1; -; Genomic_DNA.
DR   EMBL; U01666; AAA03334.1; -; Genomic_DNA.
DR   RefSeq; WP_003981021.1; NZ_SADA01000149.1.
DR   PDB; 1NQ4; NMR; -; A=1-95.
DR   PDBsum; 1NQ4; -.
DR   AlphaFoldDB; P43677; -.
DR   BMRB; P43677; -.
DR   SMR; P43677; -.
DR   GeneID; 66859935; -.
DR   OMA; EFTELGY; -.
DR   UniPathway; UPA00926; -.
DR   EvolutionaryTrace; P43677; -.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic biosynthesis; Phosphopantetheine; Phosphoprotein.
FT   CHAIN           1..95
FT                   /note="Oxytetracycline polyketide synthase acyl carrier
FT                   protein"
FT                   /id="PRO_0000180253"
FT   DOMAIN          3..81
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         41
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   HELIX           6..17
FT                   /evidence="ECO:0007829|PDB:1NQ4"
FT   STRAND          30..32
FT                   /evidence="ECO:0007829|PDB:1NQ4"
FT   HELIX           34..37
FT                   /evidence="ECO:0007829|PDB:1NQ4"
FT   HELIX           42..54
FT                   /evidence="ECO:0007829|PDB:1NQ4"
FT   HELIX           63..66
FT                   /evidence="ECO:0007829|PDB:1NQ4"
FT   HELIX           70..83
FT                   /evidence="ECO:0007829|PDB:1NQ4"
SQ   SEQUENCE   95 AA;  9916 MW;  D0C92084807BB244 CRC64;
     MTLLTLSDLL TLLRECAGEE ESIDLGGDVE DVAFDALGYD SLALLNTVGR IERDYGVQLG
     DDAVEKATTP RALIEMTNAS LTGASPSAGG AARDK