CSI1_YEAST
ID CSI1_YEAST Reviewed; 295 AA.
AC Q04368; D6VZJ9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Cop9 signalosome-interactor 1;
GN Name=CSI1; OrderedLocusNames=YMR025W; ORFNames=YM9711.15;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
RX PubMed=12186635; DOI=10.1186/1471-2156-3-15;
RA Wee S., Hetfeld B., Dubiel W., Wolf D.A.;
RT "Conservation of the COP9/signalosome in budding yeast.";
RL BMC Genet. 3:15-15(2002).
RN [4]
RP INTERACTION WITH CSN9 AND CSN12, IDENTIFICATION IN THE COP9 SIGNALOSOME
RP COMPLEX, AND FUNCTION OF THE COP9 SIGNALOSOME COMPLEX.
RX PubMed=12446563; DOI=10.1093/embo-reports/kvf235;
RA Maytal-Kivity V., Piran R., Pick E., Hofmann K., Glickman M.H.;
RT "COP9 signalosome components play a role in the mating pheromone response
RT of S. cerevisiae.";
RL EMBO Rep. 3:1215-1221(2002).
RN [5]
RP INTERACTION WITH RRI1/CSN5, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=11805826; DOI=10.1038/415141a;
RA Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A.,
RA Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C.,
RA Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M.,
RA Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C.,
RA Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V.,
RA Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B.,
RA Neubauer G., Superti-Furga G.;
RT "Functional organization of the yeast proteome by systematic analysis of
RT protein complexes.";
RL Nature 415:141-147(2002).
RN [6]
RP INTERACTION WITH CSN9; CSN12 AND RPN5, AND IDENTIFICATION IN THE COP9
RP SIGNALOSOME COMPLEX.
RX PubMed=12672462; DOI=10.1016/s1357-2725(02)00378-3;
RA Maytal-Kivity V., Pick E., Piran R., Hofmann K., Glickman M.H.;
RT "The COP9 signalosome-like complex in S. cerevisiae and links to other PCI
RT complexes.";
RL Int. J. Biochem. Cell Biol. 35:706-715(2003).
CC -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that acts as
CC an regulator of the ubiquitin (Ubl) conjugation pathway by mediating
CC the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-
CC protein ligase complexes The CSN complex is involved in the regulation
CC of the mating pheromone response. {ECO:0000269|PubMed:12186635,
CC ECO:0000269|PubMed:12446563}.
CC -!- SUBUNIT: Component of a COP9 signalosome-like (CSN) complex, composed
CC of RRI1/CSN5, CSN9, RRI2/CSN10, PCI8/CSN11, CSN12 and CSI1. In the
CC complex, it probably interacts directly with CSN9 and CSN12. Interacts
CC also with RPN5. {ECO:0000269|PubMed:11805826,
CC ECO:0000269|PubMed:12446563, ECO:0000269|PubMed:12672462}.
CC -!- INTERACTION:
CC Q04368; Q03981: CSN9; NbExp=5; IntAct=EBI-28044, EBI-33535;
CC Q04368; Q12468: RRI1; NbExp=3; IntAct=EBI-28044, EBI-37511;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
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DR EMBL; Z49211; CAA89128.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09923.1; -; Genomic_DNA.
DR PIR; S54027; S54027.
DR RefSeq; NP_013738.1; NM_001182521.1.
DR AlphaFoldDB; Q04368; -.
DR BioGRID; 35197; 150.
DR ComplexPortal; CPX-1894; COP9 signalosome complex.
DR DIP; DIP-1810N; -.
DR IntAct; Q04368; 7.
DR MINT; Q04368; -.
DR STRING; 4932.YMR025W; -.
DR MaxQB; Q04368; -.
DR PaxDb; Q04368; -.
DR PRIDE; Q04368; -.
DR EnsemblFungi; YMR025W_mRNA; YMR025W; YMR025W.
DR GeneID; 855040; -.
DR KEGG; sce:YMR025W; -.
DR SGD; S000004627; CSI1.
DR VEuPathDB; FungiDB:YMR025W; -.
DR HOGENOM; CLU_082192_0_0_1; -.
DR InParanoid; Q04368; -.
DR OMA; GYKIENS; -.
DR BioCyc; YEAST:G3O-32730-MON; -.
DR PRO; PR:Q04368; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q04368; protein.
DR GO; GO:0008180; C:COP9 signalosome; IDA:SGD.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IC:ComplexPortal.
DR GO; GO:0000754; P:adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion; IMP:SGD.
DR GO; GO:0000338; P:protein deneddylation; IMP:SGD.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Signalosome.
FT CHAIN 1..295
FT /note="Cop9 signalosome-interactor 1"
FT /id="PRO_0000079398"
SQ SEQUENCE 295 AA; 34520 MW; 709BA7D999EBE4D6 CRC64;
MDLLKFSSLA ISEINFLHES SFDSIDHSWF LLIGCKLDQD DEIYIPINGN EAESQWYIEK
VIRIPMQEND KINQERLERR INLTKVTQKD ICILGILDLC QLEEDENITN KVTEKVLTQL
TALALKYLIK YNVFRQHTSF QEAVNSLKGY KIENSVQIGA EIILDFLQDK VQIKDVNDRY
QIPTPNNTVD PGFDEFQLID MKDKEINIQK YNNNTIRKLL EKINRMIIFL KNYDATDKPF
SSTQDVILRK ISMLVTQLQR GGTSDMNYLL DNKINEIKLL EISCKQWEIS NMLKK
