CSI2_ARATH
ID CSI2_ARATH Reviewed; 2114 AA.
AC Q9C6Y4;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein CELLULOSE SYNTHASE INTERACTIVE 2 {ECO:0000303|PubMed:20616083};
GN Name=CSI2 {ECO:0000303|PubMed:20616083};
GN OrderedLocusNames=At1g44120 {ECO:0000312|Araport:AT1G44120};
GN ORFNames=T7O23.25 {ECO:0000312|EMBL:AAG50555.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=20616083; DOI=10.1073/pnas.1007092107;
RA Gu Y., Kaplinsky N., Bringmann M., Cobb A., Carroll A., Sampathkumar A.,
RA Baskin T.I., Persson S., Somerville C.R.;
RT "Identification of a cellulose synthase-associated protein required for
RT cellulose biosynthesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:12866-12871(2010).
RN [4]
RP REVIEW.
RX PubMed=25262237; DOI=10.1016/b978-0-12-800178-3.00001-4;
RA Hamada T.;
RT "Microtubule organization and microtubule-associated proteins in plant
RT cells.";
RL Int. Rev. Cell Mol. Biol. 312:1-52(2014).
CC -!- FUNCTION: Regulator of the microtubular cytoskeleton. Microtubule-
CC associated protein involved in the association of cellulase synthase
CC (CESA) complexes (CSCs) and cortical microtubules. Promotes dynamics of
CC CSCs in the plasma membrane. Regulates primary cell wall biosynthesis
CC and cellulose microfibrils organization.
CC {ECO:0000250|UniProtKB:F4IIM1}.
CC -!- SUBUNIT: Associates with cellulase synthase (CESA) complexes. Binds to
CC cortical microtubules. {ECO:0000250|UniProtKB:F4IIM1}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:F4IIM1};
CC Peripheral membrane protein {ECO:0000305}; Cytoplasmic side
CC {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:F4IIM1}.
CC Note=Colocalizes with cellulase synthase (CESA) complexes (CSCs) in a
CC dynamic way. {ECO:0000250|UniProtKB:F4IIM1}.
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DR EMBL; AC074228; AAG50555.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32022.1; -; Genomic_DNA.
DR PIR; E96505; E96505.
DR RefSeq; NP_175078.1; NM_103538.1.
DR AlphaFoldDB; Q9C6Y4; -.
DR IntAct; Q9C6Y4; 1.
DR STRING; 3702.AT1G44120.1; -.
DR iPTMnet; Q9C6Y4; -.
DR PaxDb; Q9C6Y4; -.
DR PRIDE; Q9C6Y4; -.
DR ProteomicsDB; 222656; -.
DR EnsemblPlants; AT1G44120.1; AT1G44120.1; AT1G44120.
DR GeneID; 841015; -.
DR Gramene; AT1G44120.1; AT1G44120.1; AT1G44120.
DR KEGG; ath:AT1G44120; -.
DR Araport; AT1G44120; -.
DR TAIR; locus:2205866; AT1G44120.
DR eggNOG; KOG0167; Eukaryota.
DR HOGENOM; CLU_233004_0_0_1; -.
DR InParanoid; Q9C6Y4; -.
DR OMA; AARICAF; -.
DR PhylomeDB; Q9C6Y4; -.
DR PRO; PR:Q9C6Y4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6Y4; baseline and differential.
DR GO; GO:0010330; C:cellulose synthase complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0051211; P:anisotropic cell growth; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:2001006; P:regulation of cellulose biosynthetic process; IEA:InterPro.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 7.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR044297; CSI1/2/3.
DR PANTHER; PTHR46369; PTHR46369; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00185; ARM; 13.
DR SMART; SM00239; C2; 1.
DR SUPFAM; SSF48371; SSF48371; 4.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cell shape; Cell wall biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Developmental protein; Growth regulation; Membrane;
KW Reference proteome; Repeat.
FT CHAIN 1..2114
FT /note="Protein CELLULOSE SYNTHASE INTERACTIVE 2"
FT /id="PRO_0000438334"
FT REPEAT 2..42
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 46..87
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 89..128
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 135..177
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 180..219
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 222..262
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 265..305
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 354..394
FT /note="ARM 8"
FT /evidence="ECO:0000255"
FT REPEAT 396..435
FT /note="ARM 9"
FT /evidence="ECO:0000255"
FT REPEAT 479..519
FT /note="ARM 10"
FT /evidence="ECO:0000255"
FT REPEAT 522..561
FT /note="ARM 11"
FT /evidence="ECO:0000255"
FT REPEAT 563..595
FT /note="ARM 12"
FT /evidence="ECO:0000255"
FT REPEAT 601..640
FT /note="ARM 13"
FT /evidence="ECO:0000255"
FT REPEAT 643..682
FT /note="ARM 14"
FT /evidence="ECO:0000255"
FT REPEAT 708..750
FT /note="ARM 15"
FT /evidence="ECO:0000255"
FT REPEAT 774..816
FT /note="ARM 16"
FT /evidence="ECO:0000255"
FT REPEAT 825..865
FT /note="ARM 17"
FT /evidence="ECO:0000255"
FT REPEAT 870..910
FT /note="ARM 18"
FT /evidence="ECO:0000255"
FT REPEAT 914..953
FT /note="ARM 19"
FT /evidence="ECO:0000255"
FT REPEAT 994..1033
FT /note="ARM 20"
FT /evidence="ECO:0000255"
FT REPEAT 1044..1083
FT /note="ARM 21"
FT /evidence="ECO:0000255"
FT REPEAT 1087..1128
FT /note="ARM 22"
FT /evidence="ECO:0000255"
FT REPEAT 1141..1182
FT /note="ARM 23"
FT /evidence="ECO:0000255"
FT REPEAT 1185..1225
FT /note="ARM 24"
FT /evidence="ECO:0000255"
FT REPEAT 1227..1264
FT /note="ARM 25"
FT /evidence="ECO:0000255"
FT REPEAT 1265..1304
FT /note="ARM 26"
FT /evidence="ECO:0000255"
FT REPEAT 1312..1353
FT /note="ARM 27"
FT /evidence="ECO:0000255"
FT REPEAT 1355..1394
FT /note="ARM 28"
FT /evidence="ECO:0000255"
FT REPEAT 1396..1435
FT /note="ARM 29"
FT /evidence="ECO:0000255"
FT REPEAT 1454..1494
FT /note="ARM 30"
FT /evidence="ECO:0000255"
FT REPEAT 1496..1525
FT /note="ARM 31"
FT /evidence="ECO:0000255"
FT REPEAT 1526..1564
FT /note="ARM 32"
FT /evidence="ECO:0000255"
FT REPEAT 1566..1605
FT /note="ARM 33"
FT /evidence="ECO:0000255"
FT REPEAT 1606..1648
FT /note="ARM 34"
FT /evidence="ECO:0000255"
FT REPEAT 1650..1689
FT /note="ARM 35"
FT /evidence="ECO:0000255"
FT REPEAT 1690..1730
FT /note="ARM 36"
FT /evidence="ECO:0000255"
FT REPEAT 1732..1771
FT /note="ARM 37"
FT /evidence="ECO:0000255"
FT REPEAT 1772..1813
FT /note="ARM 38"
FT /evidence="ECO:0000255"
FT REPEAT 1816..1855
FT /note="ARM 39"
FT /evidence="ECO:0000255"
FT REPEAT 1857..1898
FT /note="ARM 40"
FT /evidence="ECO:0000255"
FT REPEAT 1901..1940
FT /note="ARM 41"
FT /evidence="ECO:0000255"
FT REPEAT 1949..1993
FT /note="ARM 42"
FT /evidence="ECO:0000255"
FT DOMAIN 1974..2087
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
SQ SEQUENCE 2114 AA; 230854 MW; 76E0C52A69B09AC4 CRC64;
MTSEMDDPEK AAVTITRLIE QLHAKKSSAQ EKELSTARLL GLAKGKKECR KIISQNVNAM
PAFISLLRSG TLLAKLNSAS VLTVLCKDKN VRSKILIGGC IPPLLSLLKS DSVDAKRVVA
EAIYEVSLCG MDGDNVGTKI FVTEGVVPSL WDQLKTGKKQ DKTVEGHLVG ALRNLCGDKD
GFWALTLEDG GVDIILKLLQ SSNPVSQSNA ASLLARLIRI FTSSISKVEE SGAVQVLVQL
LGEENSVFVR ASVVNALEAI TSKSEEAITV ARDLDGIHLL ISAVVASSKE SVEEETERVL
QSYGTQALAN LCGGMSGLIV YLGGLSLSPR LTEPIADILG ALAYALRKFQ LSCGDTREAF
DPTLTEGILV KLLKPRDTQL IHERILEAME SLFGNVDLSK LLNNVDAKRV LVCLTILATD
GPRERMITCL SNLCKHGDVW DAIGKREGIQ ILIPYLGLSS EQHQELSVEF LAILTDNVEE
SRWAVTSAGG IPPLLQILET GVSQKAKDDA VRVILNLCCH SEEIRLCVEK AGAIPALLGL
LKNGGPKSQE SSANTLLKLI KTADPSVIEQ VQALFLGDAP KSKTHLIRVL GHVLASASLE
EFVTKGSAAN NGLRSLVQRL ASSNEKMKEN AASVLADLFS SRKDLCGGLG FDEDDNPCTK
LLSGNTHAVA TQLAHALGSL SNPTKKKTAT KKLSGPEVEV IKPLIKSAKT NPIESTENPM
STLANLLSDP NVAAEALNDD VVSALTRVLR EGTLQGKRNA SHALHQLLKH FQVSDVFKGN
EQCRFAVSEL IDLLNATDLN NSAFIDVLEV LSLLAKAKYG ANLSHNPFSA FGEVPSNLDS
LVRGLAEGHP LVQDKAIEIL SRFCKTQFIL LGRLLVTQSK SISSLANRTI NSSSPEIKVG
GAILLVCAAK NDITLWAEAV EQSGYLKTLV NTLLDMSKQN SKSASYGIEI QRPRSFITSN
LCLRMDDSEM VDPVTILGST ASMWLLSIIC SSHPSNRLVV MEGNGLEIIA ENLQRNKSNT
QENSSDSEEK WIAMSFLAVM SQEPKVVSSP ATENILQTLA PFMQSEQMID GYFTAQVLAA
LVRHKNDKTI SEIMNSDIVE TTINLVGCEE SDTRSLCALA EELSLVQNPY EATLEVLFEN
ERVRSGSFTK KCIPLLVNLL KPYADKVGGI PVAIRLLRRI ADNDDLSKLL IAEAGALDAL
AKYLSLSPQD STEITVSELL ESLFRSPEIT RHKTAISSMK QLIGILHLAS RSTRYNAARV
LCELFSSEHI RDSELAWKAL SPLIEMLNTT LESERVAALT ALVKLTMGIN PRPDILTSLE
GNPLDNIYKI LSLDSSSLES KTSAARICRF LFTNEGLRTS TSAACCIVSL ISLIRTGKST
AIEAGMFALD RLLDIKRFVE VAEEHDCVNL FYGYVASENY LISEAAISCL TKMAKDNTPR
KMDLIKMGII EKCISQLSKS PPSSLCSVIA DLFRVLTNVG VIARSQDAIK MVQPLLLILL
RQDLDFQGQL GGLQAIANIL EKPMVLESLK IASSTIIMPL IPLLESESIA VKNATTILLT
SLLEMQRFQE EITTKNLIAP LVKLVGIRVR NLQEIALMGL ERSSVTWPKE VADTGGIQEL
SKVIIDEDPQ LPVYLWESAA FILCNILRIN PEHYYFTVTI PVLSKMLFST AESTVILAID
ALIIRENQDS SSVQEMAESS ALDALLDLLR SHHCEELSAR LLELILRNPK VRETKICQFV
LTPLSEYILD PDTISESAKI LIAMALGDIS QHEGLAKATD SPVACRALIS LLEDEPSEEM
QMVVMRALEN FAMHSRTSRK AMAEAGGVYW VQEMLRSSNP QVSTQAALII KSLFSNHTLQ
EYVSGEIIKS LTNAMEREFW TTTAINVEIV RTLNTILTTF PKLRSSEAAT ACIPHLIGAL
KSGEQEARDS AMDTIYTLRQ SWTTMPTETA RSQAVLAADA IPVLQLMMKS KLKSPAPSSF
HERGNSLLNC LPGSLTVAIK RGDNLKRSNA FCRLIIDNCP TKKTKVVKRS SSPVWKESFT
WDFAAPPRGQ FLEIVCKSNN IFRNKNLGKV RIPIDKVLSE GSYSGIFKLN DESKKDNSSD
RSLEIEIVWS NQSF
