ID   ACPX_STRVN              Reviewed;          85 AA.
AC   P12885;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Granaticin polyketide synthase acyl carrier protein;
DE            Short=ACP;
GN   ORFNames=gra-orf3;
OS   Streptomyces violaceoruber.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1935;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tu22;
RX   PubMed=2583128; DOI=10.1002/j.1460-2075.1989.tb08413.x;
RA   Sherman D.H., Malpartida F., Bibb M.J., Kieser H.M., Bibb M.J.,
RA   Hopwood D.A.;
RT   "Structure and deduced function of the granaticin-producing polyketide
RT   synthase gene cluster of Streptomyces violaceoruber Tu22.";
RL   EMBO J. 8:2717-2725(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tu22;
RX   PubMed=9831526; DOI=10.1016/s1074-5521(98)90292-7;
RA   Ichinose K., Bedford D.J., Tornus D., Bechthold A., Bibb M.J., Revill W.P.,
RA   Floss H.G., Hopwood D.A.;
RT   "The granaticin biosynthetic gene cluster of Streptomyces violaceoruber
RT   Tu22: sequence analysis and expression in a heterologous host.";
RL   Chem. Biol. 5:647-659(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Tu22;
RX   PubMed=7476861; DOI=10.1007/bf02423457;
RA   Bechthold A., Sohng J.K., Smith T.M., Chu X., Floss H.G.;
RT   "Identification of Streptomyces violaceoruber Tu22 genes involved in the
RT   biosynthesis of granaticin.";
RL   Mol. Gen. Genet. 248:610-620(1995).
CC   -!- FUNCTION: Acyl carrier protein.
CC   -!- PATHWAY: Antibiotic biosynthesis; granaticin biosynthesis.
CC   -!- PTM: 4'-phosphopantetheine is transferred from CoA to a specific serine
CC       of the apo-ACP-like protein. {ECO:0000305}.
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DR   EMBL; X16300; CAA34371.1; -; Genomic_DNA.
DR   EMBL; X16144; CAA34266.1; -; Genomic_DNA.
DR   EMBL; AJ011500; CAA09655.1; -; Genomic_DNA.
DR   PIR; S05395; S05395.
DR   AlphaFoldDB; P12885; -.
DR   SMR; P12885; -.
DR   UniPathway; UPA00175; -.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Phosphopantetheine; Phosphoprotein.
FT   CHAIN           1..85
FT                   /note="Granaticin polyketide synthase acyl carrier protein"
FT                   /id="PRO_0000180254"
FT   DOMAIN          3..81
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         41
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   85 AA;  8991 MW;  85DB4CD855C84849 CRC64;
     MARLTLDGLR TILVACAGED DGVDLSGDIL DITFEELGYD SLALMESASR IERELGVALA
     DGDINEELTP RVLLDLVNGA QAEAA