CSK2B_CAEEL
ID CSK2B_CAEEL Reviewed; 234 AA.
AC P28548; O62352; Q22077;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Casein kinase II subunit beta;
DE Short=CK II beta;
GN Name=kin-10; Synonyms=kin-5; ORFNames=T01G9.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
RX PubMed=1918084; DOI=10.1016/s0021-9258(18)55062-6;
RA Hu E., Rubin C.S.;
RT "Casein kinase II from Caenorhabditis elegans. Cloning, characterization,
RT and developmental regulation of the gene encoding the beta subunit.";
RL J. Biol. Chem. 266:19796-19802(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, INTERACTION WITH LOV-1, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=16481400; DOI=10.1091/mbc.e05-10-0935;
RA Hu J., Bae Y.-K., Knobel K.M., Barr M.M.;
RT "Casein kinase II and calcineurin modulate TRPP function and ciliary
RT localization.";
RL Mol. Biol. Cell 17:2200-2211(2006).
CC -!- FUNCTION: Participates in Wnt signaling. Plays a complex role in
CC regulating the basal catalytic activity of the alpha subunit (By
CC similarity). Modulates two aspects of male mating behavior; response to
CC hermaphrodite contact and vulval location, acting in the same pathway
CC as lov-1 and pkd-2. {ECO:0000250, ECO:0000269|PubMed:16481400}.
CC -!- SUBUNIT: Tetramer of two alpha and two beta subunits. Interacts (via C-
CC terminus) with lov-1 (via PLAT domain). {ECO:0000269|PubMed:16481400}.
CC -!- INTERACTION:
CC P28548; P18334: kin-3; NbExp=5; IntAct=EBI-317777, EBI-367861;
CC P28548; Q11184: let-756; NbExp=3; IntAct=EBI-317777, EBI-3843983;
CC P28548; Q09624: lov-1; NbExp=2; IntAct=EBI-317777, EBI-2529627;
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000269|PubMed:16481400}. Cell projection, cilium
CC {ECO:0000269|PubMed:16481400}. Cell projection, dendrite
CC {ECO:0000269|PubMed:16481400}. Perikaryon
CC {ECO:0000269|PubMed:16481400}. Note=Enriched in cilia in male sensory
CC neurons.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P28548-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P28548-2; Sequence=VSP_001093;
CC -!- TISSUE SPECIFICITY: Expressed in a subset of the adult male sensory
CC neurons: CEM head neurons, ray RnB neurons, and hook HOB tail neurons.
CC {ECO:0000269|PubMed:16481400}.
CC -!- DEVELOPMENTAL STAGE: Elevated levels are observed during embryogenesis,
CC liver regeneration, and adipocyte differentiation.
CC -!- PTM: Phosphorylated by alpha subunit. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC {ECO:0000305}.
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DR EMBL; M73827; AAA27983.1; -; Genomic_DNA.
DR EMBL; Z75713; CAB00056.1; -; Genomic_DNA.
DR EMBL; Z75713; CAB00053.1; -; Genomic_DNA.
DR PIR; B87852; B87852.
DR PIR; T24317; T24317.
DR RefSeq; NP_492254.1; NM_059853.3.
DR RefSeq; NP_492255.1; NM_059854.4.
DR AlphaFoldDB; P28548; -.
DR SMR; P28548; -.
DR BioGRID; 38044; 29.
DR IntAct; P28548; 15.
DR STRING; 6239.T01G9.6b.1; -.
DR EPD; P28548; -.
DR PaxDb; P28548; -.
DR PeptideAtlas; P28548; -.
DR EnsemblMetazoa; T01G9.6a.1; T01G9.6a.1; WBGene00002196. [P28548-1]
DR EnsemblMetazoa; T01G9.6a.2; T01G9.6a.2; WBGene00002196. [P28548-1]
DR EnsemblMetazoa; T01G9.6b.1; T01G9.6b.1; WBGene00002196. [P28548-2]
DR EnsemblMetazoa; T01G9.6b.2; T01G9.6b.2; WBGene00002196. [P28548-2]
DR GeneID; 172610; -.
DR UCSC; T01G9.6a.1; c. elegans. [P28548-1]
DR CTD; 172610; -.
DR WormBase; T01G9.6a; CE18168; WBGene00002196; kin-10. [P28548-1]
DR WormBase; T01G9.6b; CE06343; WBGene00002196; kin-10. [P28548-2]
DR eggNOG; KOG3092; Eukaryota.
DR GeneTree; ENSGT00390000003781; -.
DR HOGENOM; CLU_034027_3_3_1; -.
DR InParanoid; P28548; -.
DR OMA; DADFGRC; -.
DR OrthoDB; 1335521at2759; -.
DR PhylomeDB; P28548; -.
DR Reactome; R-CEL-1483191; Synthesis of PC.
DR Reactome; R-CEL-201688; WNT mediated activation of DVL.
DR Reactome; R-CEL-2514853; Condensation of Prometaphase Chromosomes.
DR Reactome; R-CEL-445144; Signal transduction by L1.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-6804756; Regulation of TP53 Activity through Phosphorylation.
DR Reactome; R-CEL-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-CEL-8934903; Receptor Mediated Mitophagy.
DR Reactome; R-CEL-8948751; Regulation of PTEN stability and activity.
DR SignaLink; P28548; -.
DR PRO; PR:P28548; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00002196; Expressed in embryo and 4 other tissues.
DR GO; GO:0030424; C:axon; IDA:UniProtKB.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IDA:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IDA:UniProtKB.
DR GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005956; C:protein kinase CK2 complex; IDA:WormBase.
DR GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR GO; GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0034606; P:response to hermaphrodite contact; IMP:UniProtKB.
DR GO; GO:0034608; P:vulval location; IMP:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1820.10; -; 1.
DR InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR InterPro; IPR035991; Casein_kinase_II_beta-like.
DR InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR PANTHER; PTHR11740; PTHR11740; 1.
DR Pfam; PF01214; CK_II_beta; 1.
DR PRINTS; PR00472; CASNKINASEII.
DR SMART; SM01085; CK_II_beta; 1.
DR SUPFAM; SSF57798; SSF57798; 1.
DR PROSITE; PS01101; CK2_BETA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Behavior; Cell projection; Cilium; Phosphoprotein;
KW Reference proteome; Wnt signaling pathway.
FT CHAIN 1..234
FT /note="Casein kinase II subunit beta"
FT /id="PRO_0000068244"
FT MOD_RES 2
FT /note="Phosphoserine; by autocatalysis"
FT /evidence="ECO:0000305"
FT VAR_SEQ 58
FT /note="P -> PE (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_001093"
FT CONFLICT 141
FT /note="D -> M (in Ref. 1; AAA27983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 234 AA; 26436 MW; 634E76B78761AD74 CRC64;
MSSSEEVSWI TWFCGLRGNE FFCEVDEEYI QDRFNLTGLN EQVPKYRQAL DMILDLEPDD
IEDNATNTDL VEQAAEMLYG LIHARYILTN RGISQMVEKW RDHDFGVCPR VYCENQPMLP
IGLSDVPGEA MVKLYCPRCN DVFVPRSSRH QHTDGSYFGT GFPHMLFFVH PDLRPRRPVT
QFVPKLYGFK IHPVAYGGQE GNSGGNTANN VAAAQNNTTP AGQQSGGQFN NYGL
