ID   CSK2B_CHICK             Reviewed;         215 AA.
AC   P67869; P07312; P13862;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Casein kinase II subunit beta;
DE            Short=CK II beta;
DE   AltName: Full=Phosvitin;
GN   Name=CSNK2B; Synonyms=CK2N;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1989988; DOI=10.1016/s0021-9258(18)52252-3;
RA   Maridor G., Park W., Krek W., Nigg E.A.;
RT   "Casein kinase II. cDNA sequences, developmental expression, and tissue
RT   distribution of mRNAs for alpha, alpha', and beta subunits of the chicken
RT   enzyme.";
RL   J. Biol. Chem. 266:2362-2368(1991).
CC   -!- FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the
CC       kinase complex regulates the basal catalytic activity of the alpha
CC       subunit a constitutively active serine/threonine-protein kinase that
CC       phosphorylates a large number of substrates containing acidic residues
CC       C-terminal to the phosphorylated serine or threonine (By similarity).
CC       Participates in Wnt signaling. {ECO:0000250|UniProtKB:P67870,
CC       ECO:0000250|UniProtKB:P67871}.
CC   -!- SUBUNIT: Casein kinase II/CK2 is a tetramer composed of an alpha
CC       subunit, an alpha' subunit and two beta subunits. The beta subunit
CC       dimerization is mediated by zinc ions. {ECO:0000250|UniProtKB:P67870}.
CC   -!- PTM: Phosphorylated by alpha subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; M59458; AAA48692.1; -; mRNA.
DR   PIR; C38611; C38611.
DR   RefSeq; NP_001244133.1; NM_001257204.1.
DR   AlphaFoldDB; P67869; -.
DR   SMR; P67869; -.
DR   BioGRID; 2866030; 1.
DR   MINT; P67869; -.
DR   Allergome; 2743; Gal d Phosvitin.
DR   iPTMnet; P67869; -.
DR   GeneID; 112530988; -.
DR   CTD; 1460; -.
DR   InParanoid; P67869; -.
DR   PhylomeDB; P67869; -.
DR   PRO; PR:P67869; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005956; C:protein kinase CK2 complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1820.10; -; 1.
DR   InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR   InterPro; IPR035991; Casein_kinase_II_beta-like.
DR   InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR   PANTHER; PTHR11740; PTHR11740; 1.
DR   Pfam; PF01214; CK_II_beta; 1.
DR   PRINTS; PR00472; CASNKINASEII.
DR   SMART; SM01085; CK_II_beta; 1.
DR   SUPFAM; SSF57798; SSF57798; 1.
DR   PROSITE; PS01101; CK2_BETA; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Phosphoprotein; Reference proteome; Wnt signaling pathway;
KW   Zinc.
FT   CHAIN           1..215
FT                   /note="Casein kinase II subunit beta"
FT                   /id="PRO_0000068241"
FT   REGION          188..193
FT                   /note="Interaction with alpha subunit"
FT                   /evidence="ECO:0000250"
FT   BINDING         109
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         114
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         137
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         140
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         2
FT                   /note="Phosphoserine; by autocatalysis"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   215 AA;  24942 MW;  E465B1E699B0E0EC CRC64;
     MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE
     ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML
     PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA
     NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR