ID   CSK2B_DANRE             Reviewed;         215 AA.
AC   Q91398;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Casein kinase II subunit beta;
DE            Short=CK II beta;
GN   Name=csnk2b; Synonyms=ck2b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7735317;
RA   Daniotti J.L., Allende M.L., Weinberg E.S., Allende J.E.;
RT   "Cloning and expression of genes coding for protein kinase CK2 alpha and
RT   beta subunits in zebrafish (Danio rerio).";
RL   Cell. Mol. Biol. Res. 40:431-439(1994).
CC   -!- FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the
CC       kinase complex regulates the basal catalytic activity of the alpha
CC       subunit a constitutively active serine/threonine-protein kinase that
CC       phosphorylates a large number of substrates containing acidic residues
CC       C-terminal to the phosphorylated serine or threonine (By similarity).
CC       Participates in Wnt signaling (By similarity).
CC       {ECO:0000250|UniProtKB:P67870, ECO:0000250|UniProtKB:P67871}.
CC   -!- SUBUNIT: Casein kinase II/CK2 is a tetramer composed of two alpha
CC       subunits and two beta subunits. The beta subunit dimerization is
CC       mediated by zinc ions. {ECO:0000250, ECO:0000250|UniProtKB:P67870}.
CC   -!- PTM: Phosphorylated by alpha subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; S76877; AAB34249.1; -; mRNA.
DR   RefSeq; NP_571262.1; NM_131187.1.
DR   RefSeq; XP_005170056.1; XM_005169999.3.
DR   AlphaFoldDB; Q91398; -.
DR   SMR; Q91398; -.
DR   BioGRID; 78614; 1.
DR   STRING; 7955.ENSDARP00000098474; -.
DR   PaxDb; Q91398; -.
DR   Ensembl; ENSDART00000109258; ENSDARP00000098474; ENSDARG00000077776.
DR   Ensembl; ENSDART00000182802; ENSDARP00000146410; ENSDARG00000077776.
DR   GeneID; 30428; -.
DR   KEGG; dre:30428; -.
DR   CTD; 1460; -.
DR   ZFIN; ZDB-GENE-990415-29; csnk2b.
DR   eggNOG; KOG3092; Eukaryota.
DR   GeneTree; ENSGT00390000003781; -.
DR   HOGENOM; CLU_034027_3_3_1; -.
DR   InParanoid; Q91398; -.
DR   OMA; DADFGRC; -.
DR   OrthoDB; 1335521at2759; -.
DR   PhylomeDB; Q91398; -.
DR   TreeFam; TF314462; -.
DR   Reactome; R-DRE-1483191; Synthesis of PC.
DR   Reactome; R-DRE-201688; WNT mediated activation of DVL.
DR   Reactome; R-DRE-2514853; Condensation of Prometaphase Chromosomes.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   Reactome; R-DRE-6804756; Regulation of TP53 Activity through Phosphorylation.
DR   Reactome; R-DRE-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR   Reactome; R-DRE-8934903; Receptor Mediated Mitophagy.
DR   Reactome; R-DRE-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR   Reactome; R-DRE-8948751; Regulation of PTEN stability and activity.
DR   PRO; PR:Q91398; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000077776; Expressed in testis and 29 other tissues.
DR   ExpressionAtlas; Q91398; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005956; C:protein kinase CK2 complex; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1820.10; -; 1.
DR   InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR   InterPro; IPR035991; Casein_kinase_II_beta-like.
DR   InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR   PANTHER; PTHR11740; PTHR11740; 1.
DR   Pfam; PF01214; CK_II_beta; 1.
DR   PRINTS; PR00472; CASNKINASEII.
DR   SMART; SM01085; CK_II_beta; 1.
DR   SUPFAM; SSF57798; SSF57798; 1.
DR   PROSITE; PS01101; CK2_BETA; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Phosphoprotein; Reference proteome; Wnt signaling pathway;
KW   Zinc.
FT   CHAIN           1..215
FT                   /note="Casein kinase II subunit beta"
FT                   /id="PRO_0000068243"
FT   REGION          188..193
FT                   /note="Interaction with alpha subunit"
FT                   /evidence="ECO:0000250"
FT   BINDING         109
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         114
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         137
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
FT   BINDING         140
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   215 AA;  24885 MW;  E47F849699B0E0EC CRC64;
     MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE
     ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML
     PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA
     NQFVPRLYGF KIHPMAYQLQ LQAASSFKSP VKAIR