CSK2B_NEUCR
ID CSK2B_NEUCR Reviewed; 333 AA.
AC Q8TG12; Q7S6V4;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Casein kinase II subunit beta-1;
DE Short=CK II beta-1;
GN Name=ckb-1; Synonyms=ckb1; ORFNames=NCU05485;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11959847; DOI=10.1101/gad.965102;
RA Yang Y., Cheng P., Liu Y.;
RT "Regulation of the Neurospora circadian clock by casein kinase II.";
RL Genes Dev. 16:994-1006(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Regulatory subunit of casein kinase II/CK2 (By similarity).
CC As part of the kinase complex regulates the basal catalytic activity of
CC the alpha subunit a constitutively active serine/threonine-protein
CC kinase that phosphorylates a large number of substrates containing
CC acidic residues C-terminal to the phosphorylated serine or threonine
CC (By similarity). {ECO:0000250|UniProtKB:P67870}.
CC -!- SUBUNIT: Tetramer composed of two alpha chains, one beta chain and one
CC beta' chain. {ECO:0000250|UniProtKB:P43639}.
CC -!- PTM: Phosphorylated by alpha subunit. {ECO:0000250|UniProtKB:P67870}.
CC -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AF494377; AAM14625.1; -; mRNA.
DR EMBL; CM002241; EAA31211.1; -; Genomic_DNA.
DR RefSeq; XP_960447.1; XM_955354.3.
DR AlphaFoldDB; Q8TG12; -.
DR SMR; Q8TG12; -.
DR STRING; 5141.EFNCRP00000005501; -.
DR EnsemblFungi; EAA31211; EAA31211; NCU05485.
DR GeneID; 3876626; -.
DR KEGG; ncr:NCU05485; -.
DR VEuPathDB; FungiDB:NCU05485; -.
DR HOGENOM; CLU_034027_1_1_1; -.
DR InParanoid; Q8TG12; -.
DR OMA; YTILDYQ; -.
DR Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR GO; GO:0032545; C:CURI complex; IEA:EnsemblFungi.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005956; C:protein kinase CK2 complex; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0034456; C:UTP-C complex; IBA:GO_Central.
DR GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:EnsemblFungi.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:EnsemblFungi.
DR GO; GO:0042790; P:nucleolar large rRNA transcription by RNA polymerase I; IEA:EnsemblFungi.
DR GO; GO:0006468; P:protein phosphorylation; IEA:EnsemblFungi.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:EnsemblFungi.
DR GO; GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0006356; P:regulation of transcription by RNA polymerase I; IEA:EnsemblFungi.
DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; IBA:GO_Central.
DR Gene3D; 1.10.1820.10; -; 1.
DR InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR InterPro; IPR035991; Casein_kinase_II_beta-like.
DR InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR PANTHER; PTHR11740; PTHR11740; 1.
DR Pfam; PF01214; CK_II_beta; 1.
DR PRINTS; PR00472; CASNKINASEII.
DR SMART; SM01085; CK_II_beta; 1.
DR SUPFAM; SSF57798; SSF57798; 1.
DR PROSITE; PS01101; CK2_BETA; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..333
FT /note="Casein kinase II subunit beta-1"
FT /id="PRO_0000068253"
FT REGION 58..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 333 AA; 37107 MW; 1744C2D1F7E1D67C CRC64;
MSSSSGVPES WIASFCSLLG HEYFAEVSEE FIEDDFNLTG LQTQVAMYKE ALEMILDVEP
EDDDDEEEED EEDEEDMSGG DGINKPHGER RHHSRIASDL SVIESSAEML YGLIHQRFIC
SRAGIQQMSE KYELGHFGIC PRTNCNQTRT LPVGLSDTPG EDTVKLFCPS CLDVYVPPNS
RFQTVDGAFF GRTFGALFLM TFPEYDLTKT GAESVSNLTR SGSDDTTVIN GMYARNIAPG
LGRGKIYQPK IYGFKVSEIA RSGPRMQWLR SKPDDLSVLD EARRYAEQQG SDDEDESMGV
SSRTASRRRG PPRRQKQNGS PMAIEQNGAE SEL
