ID   CSK2C_DROME             Reviewed;         219 AA.
AC   O96863; Q53XE8; Q9V919;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Casein kinase II subunit beta';
DE            Short=CK II beta';
DE            Short=DmCKII-beta';
GN   Name=CkIIbeta2; ORFNames=CG8914;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=10329473; DOI=10.1006/mcbr.1999.0103;
RA   Bidwai A.P., Zhao W.F., Glover C.V.C.;
RT   "A gene located at 56F1-2 in Drosophila melanogaster encodes a novel
RT   metazoan beta-like subunit of casein kinase II.";
RL   Mol. Cell Biol. Res. Commun. 1:21-28(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Testis;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in Wnt signaling (By similarity). Plays a
CC       complex role in regulating the basal catalytic activity of the alpha
CC       subunit. {ECO:0000250}.
CC   -!- SUBUNIT: Tetramer of two alpha and two beta' subunits.
CC   -!- INTERACTION:
CC       O96863; P08181: CkIIalpha; NbExp=3; IntAct=EBI-181456, EBI-93115;
CC   -!- PTM: Phosphorylated by alpha subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; U51209; AAD00080.1; -; mRNA.
DR   EMBL; AE013599; AAF57483.1; -; Genomic_DNA.
DR   EMBL; BT011563; AAS15699.1; -; mRNA.
DR   RefSeq; NP_477407.1; NM_058059.4.
DR   AlphaFoldDB; O96863; -.
DR   SMR; O96863; -.
DR   BioGRID; 62955; 5.
DR   DIP; DIP-23339N; -.
DR   IntAct; O96863; 3.
DR   STRING; 7227.FBpp0085590; -.
DR   PaxDb; O96863; -.
DR   PRIDE; O96863; -.
DR   DNASU; 37300; -.
DR   EnsemblMetazoa; FBtr0086278; FBpp0085590; FBgn0026136.
DR   GeneID; 37300; -.
DR   KEGG; dme:Dmel_CG8914; -.
DR   CTD; 37300; -.
DR   FlyBase; FBgn0026136; CkIIbeta2.
DR   VEuPathDB; VectorBase:FBgn0026136; -.
DR   eggNOG; KOG3092; Eukaryota.
DR   GeneTree; ENSGT00390000003781; -.
DR   HOGENOM; CLU_034027_3_3_1; -.
DR   InParanoid; O96863; -.
DR   OMA; WIHWFCK; -.
DR   OrthoDB; 1335521at2759; -.
DR   PhylomeDB; O96863; -.
DR   SignaLink; O96863; -.
DR   BioGRID-ORCS; 37300; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 37300; -.
DR   PRO; PR:O96863; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0026136; Expressed in testis and 10 other tissues.
DR   Genevisible; O96863; DM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005956; C:protein kinase CK2 complex; ISS:FlyBase.
DR   GO; GO:0019887; F:protein kinase regulator activity; ISS:FlyBase.
DR   GO; GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1820.10; -; 1.
DR   InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR   InterPro; IPR035991; Casein_kinase_II_beta-like.
DR   InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR   PANTHER; PTHR11740; PTHR11740; 1.
DR   Pfam; PF01214; CK_II_beta; 1.
DR   PRINTS; PR00472; CASNKINASEII.
DR   SMART; SM01085; CK_II_beta; 1.
DR   SUPFAM; SSF57798; SSF57798; 1.
DR   PROSITE; PS01101; CK2_BETA; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..219
FT                   /note="Casein kinase II subunit beta'"
FT                   /id="PRO_0000068246"
FT   MOD_RES         2
FT                   /note="Phosphothreonine; by autocatalysis"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   219 AA;  24966 MW;  E43E80AA465DB666 CRC64;
     MTDSDESSWI HWFCKQRGNE FFCEVDEEYI QDKFNLNFLD SNVKNYKCAL EVILDLNPGS
     ASEDPAEPEL EASAEKLYGL IHARFILTNR GIELMLDKYN KGEFGTCPRA FCHSQPVLPI
     GLSDNPGEDM VRIYCPKCND VYIPKASRHS NLDGAFFGTG FPHMFFMEKP DARPKRAKQK
     FVPRLYGFKI HPTAYRTAAE IQKDVTMTPV GEIDSPSHI