ID   CSK2C_NEUCR             Reviewed;         285 AA.
AC   Q8TG11; A7UW36; Q7SCY0;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Casein kinase II subunit beta-2;
DE            Short=CK II beta-2;
GN   Name=ckb-2; Synonyms=ckb2; ORFNames=NCU02754;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11959847; DOI=10.1101/gad.965102;
RA   Yang Y., Cheng P., Liu Y.;
RT   "Regulation of the Neurospora circadian clock by casein kinase II.";
RL   Genes Dev. 16:994-1006(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Regulatory subunit of casein kinase II/CK2 (By similarity).
CC       As part of the kinase complex regulates the basal catalytic activity of
CC       the alpha subunit a constitutively active serine/threonine-protein
CC       kinase that phosphorylates a large number of substrates containing
CC       acidic residues C-terminal to the phosphorylated serine or threonine
CC       (By similarity). {ECO:0000250|UniProtKB:P67870}.
CC   -!- SUBUNIT: Tetramer composed of two alpha chains, one beta chain and one
CC       beta' chain. {ECO:0000250|UniProtKB:P38930}.
CC   -!- PTM: Phosphorylated by alpha subunit. {ECO:0000250|UniProtKB:P67870}.
CC   -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AF494378; AAM14626.1; -; mRNA.
DR   EMBL; CM002236; EDO65315.1; -; Genomic_DNA.
DR   RefSeq; XP_001728406.1; XM_001728354.2.
DR   AlphaFoldDB; Q8TG11; -.
DR   SMR; Q8TG11; -.
DR   STRING; 5141.EFNCRP00000001947; -.
DR   EnsemblFungi; EDO65315; EDO65315; NCU02754.
DR   GeneID; 5847739; -.
DR   KEGG; ncr:NCU02754; -.
DR   VEuPathDB; FungiDB:NCU02754; -.
DR   HOGENOM; CLU_034027_3_2_1; -.
DR   InParanoid; Q8TG11; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005956; C:protein kinase CK2 complex; IBA:GO_Central.
DR   GO; GO:0034456; C:UTP-C complex; IBA:GO_Central.
DR   GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0006359; P:regulation of transcription by RNA polymerase III; IBA:GO_Central.
DR   Gene3D; 1.10.1820.10; -; 1.
DR   InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR   InterPro; IPR035991; Casein_kinase_II_beta-like.
DR   InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR   PANTHER; PTHR11740; PTHR11740; 1.
DR   Pfam; PF01214; CK_II_beta; 1.
DR   PRINTS; PR00472; CASNKINASEII.
DR   SMART; SM01085; CK_II_beta; 1.
DR   SUPFAM; SSF57798; SSF57798; 1.
DR   PROSITE; PS01101; CK2_BETA; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..285
FT                   /note="Casein kinase II subunit beta-2"
FT                   /id="PRO_0000068254"
FT   REGION          226..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..256
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  32573 MW;  3EB9ADAB98530194 CRC64;
     MDDFVSESES DYASYWRDWF ISSRGNEYFC EIDEDYITDR FNLTGLNTEV QYYQYALDLI
     TDVFDLDCDD DMRETIEKSA RHLYGLVHAR YIVTTRGLQK MFEKYKKADF GKCPRVMCSS
     HPLLPMGLSD VPNSKPVKLY CARCEDIYNP KSSRHAAIDG AYFGTSFHNI FFQVYPTLVP
     AKSVERYIPR CYGFKVHAAA ALVRWQNSQR DEMRRRLRKL EVESGFKDAE DEAELDDDDE
     EEEEEEEEEE ELAAMDEAEG AQQQHAAAAA GTATGGVAAG GEGVH