ID   CSK2C_SCHPO             Reviewed;         254 AA.
AC   O94281;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Casein kinase II subunit beta-2;
DE            Short=CK II beta-2;
GN   Name=ckb2 {ECO:0000312|PomBase:SPBC2G5.02c};
GN   ORFNames=SPBC2G5.02c {ECO:0000312|PomBase:SPBC2G5.02c};
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Regulatory subunit of casein kinase II/CK2 (By similarity).
CC       As part of the kinase complex regulates the basal catalytic activity of
CC       the alpha subunit a constitutively active serine/threonine-protein
CC       kinase that phosphorylates a large number of substrates containing
CC       acidic residues C-terminal to the phosphorylated serine or threonine
CC       (By similarity). {ECO:0000250|UniProtKB:P67870}.
CC   -!- SUBUNIT: Tetramer composed of two alpha chains, one beta chain and one
CC       beta' chain. {ECO:0000250|UniProtKB:P38930}.
CC   -!- PTM: Phosphorylated by alpha subunit. {ECO:0000250|UniProtKB:P67870}.
CC   -!- SIMILARITY: Belongs to the casein kinase 2 subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; CU329671; CAA21878.1; -; Genomic_DNA.
DR   PIR; T40159; T40159.
DR   RefSeq; NP_596063.1; NM_001021974.2.
DR   AlphaFoldDB; O94281; -.
DR   SMR; O94281; -.
DR   BioGRID; 276836; 97.
DR   STRING; 4896.SPBC2G5.02c.1; -.
DR   MaxQB; O94281; -.
DR   PaxDb; O94281; -.
DR   EnsemblFungi; SPBC2G5.02c.1; SPBC2G5.02c.1:pep; SPBC2G5.02c.
DR   GeneID; 2540306; -.
DR   KEGG; spo:SPBC2G5.02c; -.
DR   PomBase; SPBC2G5.02c; -.
DR   VEuPathDB; FungiDB:SPBC2G5.02c; -.
DR   eggNOG; KOG3092; Eukaryota.
DR   HOGENOM; CLU_034027_3_1_1; -.
DR   InParanoid; O94281; -.
DR   OMA; YTILDYQ; -.
DR   PhylomeDB; O94281; -.
DR   PRO; PR:O94281; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005956; C:protein kinase CK2 complex; ISO:PomBase.
DR   GO; GO:0034456; C:UTP-C complex; ISO:PomBase.
DR   GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; ISO:PomBase.
DR   GO; GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0006356; P:regulation of transcription by RNA polymerase I; ISO:PomBase.
DR   GO; GO:0006359; P:regulation of transcription by RNA polymerase III; ISO:PomBase.
DR   GO; GO:0007165; P:signal transduction; IC:PomBase.
DR   Gene3D; 1.10.1820.10; -; 1.
DR   InterPro; IPR016149; Casein_kin_II_reg-sub_N.
DR   InterPro; IPR035991; Casein_kinase_II_beta-like.
DR   InterPro; IPR000704; Casein_kinase_II_reg-sub.
DR   PANTHER; PTHR11740; PTHR11740; 2.
DR   Pfam; PF01214; CK_II_beta; 1.
DR   PRINTS; PR00472; CASNKINASEII.
DR   SMART; SM01085; CK_II_beta; 1.
DR   SUPFAM; SSF57798; SSF57798; 1.
DR   PROSITE; PS01101; CK2_BETA; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..254
FT                   /note="Casein kinase II subunit beta-2"
FT                   /id="PRO_0000068256"
SQ   SEQUENCE   254 AA;  29061 MW;  6E3DFFA18A131ED0 CRC64;
     MSRKNLIKLN HDPTVTYSTK DDADELFDDL SSSPLHENVS WISWFCSRPG REYFVEVKED
     FIEDLFNLTG LNLAVPFYNE ALDLILDRTA PDTLENFDMD VIETSAQILY GLIHQRYIIT
     RTGLHQMAEK YSMGIFGCCP RVNCCYTHVL PAGLSDIVGK MPVMLFCPNC LDLYAPSSSR
     YKNIDGSFFG ATFPHLFFES YPELNPKRSI PCGKIYQPRI YGFKVSELSK TGPRMQWLRM
     YLEDSGSDSE SESD