CSLD4_ARATH
ID CSLD4_ARATH Reviewed; 1111 AA.
AC Q9SZL9; Q84TI9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Cellulose synthase-like protein D4;
DE Short=AtCslD4;
DE EC=2.4.1.-;
GN Name=CSLD4; OrderedLocusNames=At4g38190; ORFNames=F20D10.310;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 40-1111.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11027699; DOI=10.1104/pp.124.2.495;
RA Richmond T.A., Somerville C.R.;
RT "The cellulose synthase superfamily.";
RL Plant Physiol. 124:495-498(2000).
CC -!- FUNCTION: Thought to be a Golgi-localized beta-glycan synthase that
CC polymerize the backbones of noncellulosic polysaccharides
CC (hemicelluloses) of plant cell wall.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. Plant
CC cellulose synthase-like D subfamily. {ECO:0000305}.
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DR EMBL; AL035538; CAB37559.1; -; Genomic_DNA.
DR EMBL; AL161593; CAB80484.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86891.1; -; Genomic_DNA.
DR EMBL; BT005743; AAO64152.1; -; mRNA.
DR PIR; T05646; T05646.
DR RefSeq; NP_195532.1; NM_119980.3.
DR AlphaFoldDB; Q9SZL9; -.
DR SMR; Q9SZL9; -.
DR STRING; 3702.AT4G38190.1; -.
DR CAZy; GT2; Glycosyltransferase Family 2.
DR iPTMnet; Q9SZL9; -.
DR PaxDb; Q9SZL9; -.
DR PRIDE; Q9SZL9; -.
DR ProteomicsDB; 220367; -.
DR EnsemblPlants; AT4G38190.1; AT4G38190.1; AT4G38190.
DR GeneID; 829975; -.
DR Gramene; AT4G38190.1; AT4G38190.1; AT4G38190.
DR KEGG; ath:AT4G38190; -.
DR Araport; AT4G38190; -.
DR TAIR; locus:2121080; AT4G38190.
DR eggNOG; ENOG502QTM8; Eukaryota.
DR HOGENOM; CLU_001418_1_0_1; -.
DR InParanoid; Q9SZL9; -.
DR OMA; TPCECRF; -.
DR OrthoDB; 679241at2759; -.
DR PhylomeDB; Q9SZL9; -.
DR BioCyc; ARA:AT4G38190-MON; -.
DR PRO; PR:Q9SZL9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SZL9; baseline and differential.
DR Genevisible; Q9SZL9; AT.
DR GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016760; F:cellulose synthase (UDP-forming) activity; IEA:InterPro.
DR GO; GO:0051753; F:mannan synthase activity; IBA:GO_Central.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0030244; P:cellulose biosynthetic process; IEA:InterPro.
DR GO; GO:0009833; P:plant-type primary cell wall biogenesis; IBA:GO_Central.
DR GO; GO:0009846; P:pollen germination; IMP:TAIR.
DR Gene3D; 3.30.40.10; -; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR005150; Cellulose_synth.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF03552; Cellulose_synt; 2.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 2: Evidence at transcript level;
KW Cell wall biogenesis/degradation; Glycosyltransferase; Golgi apparatus;
KW Membrane; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1111
FT /note="Cellulose synthase-like protein D4"
FT /id="PRO_0000319349"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 891..911
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 914..934
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 963..983
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1007..1027
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1040..1060
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1070..1090
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 397
FT /evidence="ECO:0000255"
FT ACT_SITE 809
FT /evidence="ECO:0000255"
SQ SEQUENCE 1111 AA; 124595 MW; 03AFF6E0CAD28157 CRC64;
MASTPPQTSK KVRNNSGSGQ TVKFARRTSS GRYVSLSRDN IELSGELSGD YSNYTVHIPP
TPDNQPMATK AEEQYVSNSL FTGGFNSVTR AHLMDKVIDS DVTHPQMAGA KGSSCAMPAC
DGNVMKDERG KDVMPCECRF KICRDCFMDA QKETGLCPGC KEQYKIGDLD DDTPDYSSGA
LPLPAPGKDQ RGNNNNMSMM KRNQNGEFDH NRWLFETQGT YGYGNAYWPQ DEMYGDDMDE
GMRGGMVETA DKPWRPLSRR IPIPAAIISP YRLLIVIRFV VLCFFLTWRI RNPNEDAIWL
WLMSIICELW FGFSWILDQI PKLCPINRST DLEVLRDKFD MPSPSNPTGR SDLPGIDLFV
STADPEKEPP LVTANTILSI LAVDYPVEKV SCYLSDDGGA LLSFEAMAEA ASFADLWVPF
CRKHNIEPRN PDSYFSLKID PTKNKSRIDF VKDRRKIKRE YDEFKVRING LPDSIRRRSD
AFNAREEMKA LKQMRESGGD PTEPVKVPKA TWMADGTHWP GTWAASTREH SKGDHAGILQ
VMLKPPSSDP LIGNSDDKVI DFSDTDTRLP MFVYVSREKR PGYDHNKKAG AMNALVRASA
ILSNGPFILN LDCDHYIYNC KAVREGMCFM MDRGGEDICY IQFPQRFEGI DPSDRYANNN
TVFFDGNMRA LDGVQGPVYV GTGTMFRRFA LYGFDPPNPD KLLEKKESET EALTTSDFDP
DLDVTQLPKR FGNSTLLAES IPIAEFQGRP LADHPAVKYG RPPGALRVPR DPLDATTVAE
SVSVISCWYE DKTEWGDRVG WIYGSVTEDV VTGYRMHNRG WRSVYCITKR DSFRGSAPIN
LTDRLHQVLR WATGSVEIFF SRNNAILASK RLKFLQRLAY LNVGIYPFTS LFLILYCFLP
AFSLFSGQFI VRTLSISFLV YLLMITICLI GLAVLEVKWS GIGLEEWWRN EQWWLISGTS
SHLYAVVQGV LKVIAGIEIS FTLTTKSGGD DNEDIYADLY IVKWSSLMIP PIVIAMVNII
AIVVAFIRTI YQAVPQWSKL IGGAFFSFWV LAHLYPFAKG LMGRRGKTPT IVFVWAGLIA
ITISLLWTAI NPNTGPAAAA EGVGGGGFQF P
