ID   CSLD4_ORYSJ             Reviewed;        1215 AA.
AC   Q2QNS6; A0A0N7KU71; A3CIC4; Q0IMP7; Q8W1N5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Cellulose synthase-like protein D4;
DE            EC=2.4.1.-;
DE   AltName: Full=OsCslD4;
GN   Name=CSLD4; OrderedLocusNames=Os12g0555600, LOC_Os12g36890;
GN   ORFNames=OsJ_035046;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 777-1215.
RX   PubMed=11842136; DOI=10.1104/pp.010875;
RA   Hazen S.P., Scott-Craig J.S., Walton J.D.;
RT   "Cellulose synthase-like genes of rice.";
RL   Plant Physiol. 128:336-340(2002).
RN   [7]
RP   TISSUE SPECIFICITY.
RX   PubMed=17259288; DOI=10.1104/pp.106.091546;
RA   Kim C.M., Park S.H., Je B.I., Park S.H., Park S.J., Piao H.L., Eun M.Y.,
RA   Dolan L., Han C.-D.;
RT   "OsCSLD1, a cellulose synthase-like D1 gene, is required for root hair
RT   morphogenesis in rice.";
RL   Plant Physiol. 143:1220-1230(2007).
CC   -!- FUNCTION: Thought to be a Golgi-localized beta-glycan synthase that
CC       polymerize the backbones of noncellulosic polysaccharides
CC       (hemicelluloses) of plant cell wall.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-
CC       pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. Plant
CC       cellulose synthase-like D subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAF30018.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAZ20837.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DP000011; ABA99552.1; -; Genomic_DNA.
DR   EMBL; AP008218; BAF30018.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014968; BAT17602.1; -; Genomic_DNA.
DR   EMBL; CM000149; EAZ20837.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AF435644; AAL38529.1; -; mRNA.
DR   RefSeq; XP_015620379.1; XM_015764893.1.
DR   AlphaFoldDB; Q2QNS6; -.
DR   SMR; Q2QNS6; -.
DR   STRING; 4530.OS12T0555600-01; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   PaxDb; Q2QNS6; -.
DR   PRIDE; Q2QNS6; -.
DR   EnsemblPlants; Os12t0555600-01; Os12t0555600-01; Os12g0555600.
DR   GeneID; 107276048; -.
DR   Gramene; Os12t0555600-01; Os12t0555600-01; Os12g0555600.
DR   KEGG; osa:107276048; -.
DR   eggNOG; ENOG502QQG2; Eukaryota.
DR   HOGENOM; CLU_001418_1_0_1; -.
DR   InParanoid; Q2QNS6; -.
DR   OMA; ATEHRGW; -.
DR   OrthoDB; 679241at2759; -.
DR   PlantReactome; R-OSA-1119314; Cellulose biosynthesis.
DR   PlantReactome; R-OSA-9627657; Regulation of leaf development.
DR   Proteomes; UP000000763; Chromosome 12.
DR   Proteomes; UP000007752; Chromosome 12.
DR   Proteomes; UP000059680; Chromosome 12.
DR   Genevisible; Q2QNS6; OS.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016760; F:cellulose synthase (UDP-forming) activity; IEA:InterPro.
DR   GO; GO:0051753; F:mannan synthase activity; IBA:GO_Central.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IEA:InterPro.
DR   GO; GO:0071669; P:plant-type cell wall organization or biogenesis; IDA:UniProtKB.
DR   GO; GO:0009833; P:plant-type primary cell wall biogenesis; IBA:GO_Central.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005150; Cellulose_synth.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF03552; Cellulose_synt; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Cell wall biogenesis/degradation; Glycosyltransferase; Golgi apparatus;
KW   Membrane; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1215
FT                   /note="Cellulose synthase-like protein D4"
FT                   /id="PRO_0000319395"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        988..1008
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1014..1034
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1060..1080
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1114..1134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1147..1167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1177..1197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          24..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..225
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        452
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        905
FT                   /evidence="ECO:0000255"
FT   CONFLICT        777..780
FT                   /note="RRKI -> DAWV (in Ref. 6; AAL38529)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1215 AA;  132161 MW;  464FA97879091C7B CRC64;
     MSRRLSLPAG APVTVAVSPV RSPGGDAVVR RGSGLTSPVP RHSLGSSTAT LQVSPVRRSG
     GSRYLGASRD GGADESAEFV HYTVHIPPTP DRATASVASE AEAAAEAEEV HRPQRSYISG
     TIFTGGLNCA TRGHVLNFSG EGGATAASRA AASGNMSCKM RGCDMPAFLN GGRPPCDCGF
     MICKECYAEC AAGNCPGCKE AFSAGSDTDE SDSVTDDDDD EAVSSSEERD QLPLTSMARK
     FSVVHSMKVP GAAANGNGKP AEFDHARWLF ETKGTYGYGN ALWPKDGHAH SGAGFVAADE
     PPNFGARCRR PLTRKTSVSQ AILSPYRLLI AIRLVALGFF LAWRIRHPNP EAVWLWAMSV
     ACEVWFAFSW LLDSLPKLCP VHRAADLAVL AERFESPTAR NPKGRSDLPG IDVFVTSADP
     EKEPPLVTAN TILSILAADY PVEKLACYLS DDGGALLSFE ALAETASFAR TWVPFCRKHG
     VEPRCPEAYF GQKRDFLKNK VRVDFVRERR KVKREYDEFK VRVNSLPEAI RRRSDAYNAG
     EELRARRRQQ EEAAAAAAAG NGELGAAAVE TAAVKATWMS DGSHWPGTWT CPAADHARGD
     HAGIIQAMLA PPTSEPVMGG EAAECGGLID TTGVDVRLPM LVYVSREKRP GYDHNKKAGA
     MNALVRTSAI MSNGPFILNL DCDHYVHNSS ALREGMCFML DRGGDRVCFV QFPQRFEGVD
     PSDRYANHNL VFFDVSMRAM DGLQGPMYVG TGCVFRRTAL YGFSPPRATE HHGWLGRRKI
     KLFLTKKKSM GKKTDRAEDD TEMMLPPIED DDGGADIEAS AMLPKRFGGS ATFVASIPVA
     EYQGRLLQDT PGCHHGRPAG ALAVPREPLD AATVAEAIGV ISCFYEEKTE WGRRIGWIYG
     SVTEDVVTGY RMHNRGWRSV YCVTPRRDAF RGTAPINLTD RLHQVLRWAT GSVEIFFSRN
     NALFASPRMK LLQRVAYFNA GMYPFTSVFL LAYCLLPAVS LFSGKFIVQR LSATFLAFLL
     VITLTLCLLA LLEIKWSGIT LHEWWRNEQF WVIGGTSAHP AAVLQGLLKV IAGVDISFTL
     TSKPGNGGGD GGVGGEGNDD EAFAELYEVR WSYLMVPPVT IMMVNAVAIA VAAARTLYSE
     FPQWSKLLGG AFFSFWVLCH LYPFAKGLLG RRGRVPTIVF VWSGLISMII SLLWVYINPP
     AGARERIGGG GFSFP