ID   CSM2_KLULA              Reviewed;         213 AA.
AC   Q6CL99;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Chromosome segregation in meiosis protein 2;
GN   Name=CSM2; OrderedLocusNames=KLLA0F04653g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in chromosome segregation during meiosis. Promotes
CC       efficient recombinational repair and functions in the protection of the
CC       genome from spontaneous and induced DNA damage like mutations and gross
CC       chromosomal rearrangements (GCRs) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSM2 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG97998.1; -; Genomic_DNA.
DR   RefSeq; XP_455290.1; XM_455290.1.
DR   AlphaFoldDB; Q6CL99; -.
DR   SMR; Q6CL99; -.
DR   STRING; 28985.XP_455290.1; -.
DR   EnsemblFungi; CAG97998; CAG97998; KLLA0_F04653g.
DR   GeneID; 2895898; -.
DR   KEGG; kla:KLLA0_F04653g; -.
DR   eggNOG; ENOG502S2QF; Eukaryota.
DR   HOGENOM; CLU_1235013_0_0_1; -.
DR   InParanoid; Q6CL99; -.
DR   OMA; YIDCKNS; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0097196; C:Shu complex; IEA:InterPro.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0000725; P:recombinational repair; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR031783; Csm2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF16834; CSM2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA repair; Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..213
FT                   /note="Chromosome segregation in meiosis protein 2"
FT                   /id="PRO_0000280684"
SQ   SEQUENCE   213 AA;  24619 MW;  101CCDFBEF788725 CRC64;
     MKIDIGVDNK CGDFVTYMKD EAFNSQLHYI SAISSFPISK MMELLPLSGN ETIYESVNVL
     SSVDLSDLNR CIRSLYQRII FSPLPKQSDA NTDDSNNSNN ANMQMETGKI KTDRHWICIE
     GIQTMFQYSQ LKDPVEAHAS LNDTMLRLRL LQNKCPSIEI LFLLPPHEAP EFIQSLQEHD
     ISRNNIPHRR QGKRFKRDNT GILIGDYIWK YYI