ID   CSM2_METJA              Reviewed;         133 AA.
AC   Q59064;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=CRISPR system Cms protein Csm2;
DE   AltName: Full=CRISPR type III A-associated protein Csm2;
GN   Name=csm2; OrderedLocusNames=MJ1670;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA). The
CC       type III-A Csm effector complex binds crRNA and acts as a crRNA-guided
CC       RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA
CC       cognate to the crRNA is required for all activities.
CC       {ECO:0000250|UniProtKB:A0A0A7HIX1}.
CC   -!- FUNCTION: This subunit may be involved in monitoring complementarity of
CC       crRNA and target RNA. {ECO:0000250|UniProtKB:A0A0A7HIX1}.
CC   -!- SUBUNIT: Part of the Csm effector complex that includes Cas10, Csm2,
CC       Csm3, Csm4 and Csm5. {ECO:0000250|UniProtKB:A0A0A7HIX1}.
CC   -!- MISCELLANEOUS: Encoded in a type III-A CRISPR locus. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated Csm2 family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB99693.1; -; Genomic_DNA.
DR   PIR; D64508; D64508.
DR   RefSeq; WP_010871194.1; NC_000909.1.
DR   AlphaFoldDB; Q59064; -.
DR   SMR; Q59064; -.
DR   STRING; 243232.MJ_1670; -.
DR   EnsemblBacteria; AAB99693; AAB99693; MJ_1670.
DR   GeneID; 1452579; -.
DR   KEGG; mja:MJ_1670; -.
DR   eggNOG; arCOG06487; Archaea.
DR   HOGENOM; CLU_131491_2_0_2; -.
DR   InParanoid; Q59064; -.
DR   OMA; KPKLAYN; -.
DR   OrthoDB; 127804at2157; -.
DR   PhylomeDB; Q59064; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd09647; Csm2_III-A; 1.
DR   InterPro; IPR010149; CRISPR-assoc_prot_Csm2_III-A.
DR   Pfam; PF03750; Csm2_III-A; 1.
DR   TIGRFAMs; TIGR01870; cas_TM1810_Csm2; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Reference proteome; RNA-binding.
FT   CHAIN           1..133
FT                   /note="CRISPR system Cms protein Csm2"
FT                   /id="PRO_0000107468"
SQ   SEQUENCE   133 AA;  15670 MW;  EF803498557B6898 CRC64;
     MSKIGKCILN PNEINLILNI NSQNANEIID IAENLAKEFE QIPATKMRDF YDYVLRIDEK
     NENWYKELVL LKPKLAYNYG KETNRRKKEA LEKLAGTFSE IIDKIDNDLN KFKNFKTFFE
     ALVAYHKIYA KSQ