ID   CSM2_MYCTO              Reviewed;         124 AA.
AC   P9WJG0; F2GLB2; L0TDN3; P71630; Q7D6I2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=CRISPR system Cms protein Csm2;
DE   AltName: Full=CRISPR type III A-associated protein Csm2;
GN   Name=csm2; OrderedLocusNames=MT2889;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA). The
CC       type III-A Csm effector complex binds crRNA and acts as a crRNA-guided
CC       RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA
CC       cognate to the crRNA is required for all activities.
CC       {ECO:0000250|UniProtKB:A0A0A7HIX1}.
CC   -!- FUNCTION: This subunit may be involved in monitoring complementarity of
CC       crRNA and target RNA. {ECO:0000250|UniProtKB:A0A0A7HIX1}.
CC   -!- SUBUNIT: Part of the Csm effector complex that includes Cas10, Csm2,
CC       Csm3, Csm4 and Csm5. {ECO:0000250|UniProtKB:P9WJG1}.
CC   -!- MISCELLANEOUS: Encoded in a type III-A CRISPR locus. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated Csm2 family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK47214.1; -; Genomic_DNA.
DR   PIR; A70692; A70692.
DR   RefSeq; WP_003414296.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJG0; -.
DR   SMR; P9WJG0; -.
DR   EnsemblBacteria; AAK47214; AAK47214; MT2889.
DR   KEGG; mtc:MT2889; -.
DR   PATRIC; fig|83331.31.peg.3118; -.
DR   HOGENOM; CLU_131491_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   CDD; cd09647; Csm2_III-A; 1.
DR   InterPro; IPR010149; CRISPR-assoc_prot_Csm2_III-A.
DR   Pfam; PF03750; Csm2_III-A; 1.
DR   TIGRFAMs; TIGR01870; cas_TM1810_Csm2; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; RNA-binding.
FT   CHAIN           1..124
FT                   /note="CRISPR system Cms protein Csm2"
FT                   /id="PRO_0000427836"
SQ   SEQUENCE   124 AA;  14287 MW;  84B303DD7A1549AA CRC64;
     MSVIQDDYVK QAEVIRGLPK KKNGFELTTT QLRVLLSLTA QLFDEAQQSA NPTLPRQLKE
     KVQYLRVRFV YQSGREDAVK TFVRNAKLLE ALEGIGDSRD GLLRFCRYME ALAAYKKYLD
     PKDK