CSM3_ASPCL
ID CSM3_ASPCL Reviewed; 267 AA.
AC A1C8Y9;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Chromosome segregation in meiosis protein 3;
GN Name=csm3; ORFNames=ACLA_053590;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Forms a fork protection complex (FPC) with tof1 and which is
CC required for chromosome segregation during meiosis and DNA damage
CC repair. FPC coordinates leading and lagging strand synthesis and moves
CC with the replication fork. FPC stabilizes replication forks in a
CC configuration that is recognized by replication checkpoint sensors (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC tof1 and csm3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR EMBL; DS027048; EAW13313.1; -; Genomic_DNA.
DR RefSeq; XP_001274739.1; XM_001274738.1.
DR AlphaFoldDB; A1C8Y9; -.
DR SMR; A1C8Y9; -.
DR STRING; 5057.CADACLAP00005043; -.
DR EnsemblFungi; EAW13313; EAW13313; ACLA_053590.
DR GeneID; 4707012; -.
DR KEGG; act:ACLA_053590; -.
DR VEuPathDB; FungiDB:ACLA_053590; -.
DR eggNOG; KOG3004; Eukaryota.
DR HOGENOM; CLU_036204_0_0_1; -.
DR OMA; DELWQET; -.
DR OrthoDB; 1505397at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0048478; P:replication fork protection; IEA:InterPro.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; PTHR13220; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..267
FT /note="Chromosome segregation in meiosis protein 3"
FT /id="PRO_0000301711"
SQ SEQUENCE 267 AA; 29916 MW; 7811E78ADC3A3730 CRC64;
MEDDSAPISG RSGSPDHVDD LFNYDFGLDE LLGQAPSRTD STEPKQTATH AMSGLGLGLD
EEVKVTKKRQ PIAKLDERRL LSQPGIPKLR RTAKAKLKFR GRGHEFSDAA RLLNFYQLWL
DNLFPRAKFA DGLAMIERLG HSKRLQTIRR EWIEEEKPQI STDIQAGSPQ INLPADTQTD
HTALASENRN TTSAKLQENL SNYVIPDGVQ NSVDDTNLPA LAEADERLFM SDDDFARLPD
DQGAPDDDEW DALLREQEDL VFINTST