ID   CSM3_CANGA              Reviewed;         309 AA.
AC   Q6FU57;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Chromosome segregation in meiosis protein 3;
GN   Name=CSM3; OrderedLocusNames=CAGL0F06149g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with TOF1 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       TOF1 and CSM3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR   EMBL; CR380952; CAG59161.1; -; Genomic_DNA.
DR   RefSeq; XP_446237.1; XM_446237.1.
DR   AlphaFoldDB; Q6FU57; -.
DR   SMR; Q6FU57; -.
DR   STRING; 5478.XP_446237.1; -.
DR   EnsemblFungi; CAG59161; CAG59161; CAGL0F06149g.
DR   GeneID; 2887729; -.
DR   KEGG; cgr:CAGL0F06149g; -.
DR   CGD; CAL0131030; CAGL0F06149g.
DR   VEuPathDB; FungiDB:CAGL0F06149g; -.
DR   eggNOG; KOG3004; Eukaryota.
DR   HOGENOM; CLU_068300_0_0_1; -.
DR   InParanoid; Q6FU57; -.
DR   OMA; FRADMEN; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0031298; C:replication fork protection complex; IEA:EnsemblFungi.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:InterPro.
DR   GO; GO:0034087; P:establishment of mitotic sister chromatid cohesion; IEA:EnsemblFungi.
DR   GO; GO:0043570; P:maintenance of DNA repeat elements; IEA:EnsemblFungi.
DR   GO; GO:0045132; P:meiotic chromosome segregation; IEA:EnsemblFungi.
DR   GO; GO:0043111; P:replication fork arrest; IEA:EnsemblFungi.
DR   GO; GO:0048478; P:replication fork protection; IEA:EnsemblFungi.
DR   InterPro; IPR012923; Csm3.
DR   InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR   PANTHER; PTHR13220; PTHR13220; 1.
DR   Pfam; PF07962; Swi3; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..309
FT                   /note="Chromosome segregation in meiosis protein 3"
FT                   /id="PRO_0000301715"
FT   REGION          141..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          275..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        287..302
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  34370 MW;  7F769AEA520EC180 CRC64;
     MDEDDMLMLG VGAEPTQHAE IEDPLTGGVA SDPTMINDDP TAVNAKVRRP QVKLTAERLL
     SPNGLPYVMK HAPKRVRISK SRSTYKNLEH IIQFYQLWAH ELFPKAKFKD FVRLCNSLGK
     TDADLRNYRT ELFRADMENQ FGDGYRSDKQ NPANNSQPVT STQLPNNDAN SNDENNNVEN
     DTNQLITGGQ ETTRHLFARD EEDDDDSDLY RSVPPPSSIA HESATSNTHA VPTSDTTLPI
     SDNNPKGVTN SDGTVIGISE EDELLAMEEE LNNYATQKIE ELGDDKDTGI DPGEEEDEDA
     LDAMKELGF