ID   CSM3_CHAGB              Reviewed;         431 AA.
AC   Q2H3R6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Chromosome segregation in meiosis protein 3;
GN   Name=CSM3; ORFNames=CHGG_06699;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with TOF1 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       TOF1 and CSM3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH408031; EAQ90080.1; -; Genomic_DNA.
DR   RefSeq; XP_001222794.1; XM_001222793.1.
DR   AlphaFoldDB; Q2H3R6; -.
DR   SMR; Q2H3R6; -.
DR   STRING; 38033.XP_001222794.1; -.
DR   EnsemblFungi; EAQ90080; EAQ90080; CHGG_06699.
DR   GeneID; 4390866; -.
DR   eggNOG; KOG3004; Eukaryota.
DR   HOGENOM; CLU_036204_1_0_1; -.
DR   InParanoid; Q2H3R6; -.
DR   OMA; DEDMWDI; -.
DR   OrthoDB; 1505397at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:InterPro.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0048478; P:replication fork protection; IEA:InterPro.
DR   InterPro; IPR012923; Csm3.
DR   InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR   PANTHER; PTHR13220; PTHR13220; 1.
DR   Pfam; PF07962; Swi3; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..431
FT                   /note="Chromosome segregation in meiosis protein 3"
FT                   /id="PRO_0000301716"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          32..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..431
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   431 AA;  46066 MW;  3BF8D35EB573774A CRC64;
     MPSKTASKAA DTASRGNTGN FVDDYLADWD DDPFRSVSPE PAKNDKDGEK KKDILGIDKE
     LDLKKKPRAP RVKLDETRLL SDKGIPKLRK MAPRLKLKGK GHEFSDAARL LSFYQEWLDD
     LFPKATFLDA LAMVEKTGHK TTMRSARQKW IDELKPRAAI EEDEEDNRIH RGAVGPQQPP
     KVASIFETTA KAAGERAKTP TTDDLFGDDL YNATPVRNTG STAPPQQAGG DVPDDDDLDA
     LMAEAEAEAR AQTQRPGPAP SSGSIFGNGA RAVAPTTTAG PDDDDLDALM AEAEAQSLPT
     RAAQPVVNGS IFGNGAKKQT TQVTGDEDDD LDALMAEAEA EAEAGVQKTA QPVDPKEVGS
     GNARAAEKTS NLDNDDDDLD ALMAEAEAEA GVGAAGGSSG DKKTSAQTET GHRTDNFDDD
     EKAMDEMDGL W