ID   CSM3_MAGO7              Reviewed;         357 AA.
AC   A4RCW0; G4NKF7; Q2KH17;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Chromosome segregation in meiosis protein 3;
GN   Name=CSM3; ORFNames=MGCH7_ch7g168, MGG_09005;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RA   Thon M.R., Pan H., Diener A., Papalas J., Taro A., Mitchell T.K.,
RA   Dean R.A.;
RT   "The sequence of Magnaporthe grisea chromosome 7.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with TOF1 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       TOF1 and CSM3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR   EMBL; CM000230; EAQ70761.1; -; Genomic_DNA.
DR   EMBL; CM001237; EHA46593.1; -; Genomic_DNA.
DR   RefSeq; XP_003721336.1; XM_003721288.1.
DR   AlphaFoldDB; A4RCW0; -.
DR   SMR; A4RCW0; -.
DR   STRING; 318829.MGG_09005T0; -.
DR   EnsemblFungi; MGG_09005T0; MGG_09005T0; MGG_09005.
DR   GeneID; 2680128; -.
DR   KEGG; mgr:MGG_09005; -.
DR   VEuPathDB; FungiDB:MGG_09005; -.
DR   eggNOG; KOG3004; Eukaryota.
DR   HOGENOM; CLU_036204_1_0_1; -.
DR   InParanoid; A4RCW0; -.
DR   OMA; WINEGRP; -.
DR   OrthoDB; 1505397at2759; -.
DR   Proteomes; UP000009058; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:InterPro.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0048478; P:replication fork protection; IEA:InterPro.
DR   InterPro; IPR012923; Csm3.
DR   InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR   PANTHER; PTHR13220; PTHR13220; 1.
DR   Pfam; PF07962; Swi3; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..357
FT                   /note="Chromosome segregation in meiosis protein 3"
FT                   /id="PRO_0000301720"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..347
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   357 AA;  38598 MW;  8D064B966A99075D CRC64;
     MSTSKAKQPS VPALDNYIPD DEDFFDPFAS PTNSPNQSPK AKGGAKRSEP DGGLGIDEEV
     SVAKRARVPR VKLDETRLLS DKGIPALRKR AGTLRLKGKG HEFSDAARLL SFYQLWLDDL
     FPKAKFLDAL AMVEKAGHKT TMHKARTDWI NDLKPNMTAP DNDGHADIGH APVAQPQSSR
     IAPIFEKRQT IDASTMPAED SNGVDDLFGG DDLGEMYDVT PKATRPVGEP DDDDIEALMA
     EAESSIRQPA PIAMSLFGSG RPAKTGTEAQ RANGSPNDED LDAVMAEAEV HTVSHGSSTA
     RKQRAQTDPG NDDDDLEALI AEAEGVLKQK PAPSHKTKDK TSSFDDEEAA MAELDLW