ACP_AEDAE
ID ACP_AEDAE Reviewed; 106 AA.
AC Q16RI5;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 2.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Adipokinetic hormone/corazonin-related peptide {ECO:0000303|PubMed:29391531};
DE Short=ACP {ECO:0000303|PubMed:29391531};
DE Short=AKH/CRZ-related peptide {ECO:0000303|PubMed:20068045};
DE Flags: Precursor;
GN ORFNames=AAEL010950 {ECO:0000312|EMBL:EAT37004.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [2]
RP FUNCTION, PYROGLUTAMATE FORMATION AT GLN-26, AMIDATION AT ALA-35, AND
RP SUBCELLULAR LOCATION.
RX PubMed=20068045; DOI=10.1074/jbc.m109.045369;
RA Hansen K.K., Stafflinger E., Schneider M., Hauser F., Cazzamali G.,
RA Williamson M., Kollmann M., Schachtner J., Grimmelikhuijzen C.J.;
RT "Discovery of a novel insect neuropeptide signaling system closely related
RT to the insect adipokinetic hormone and corazonin hormonal systems.";
RL J. Biol. Chem. 285:10736-10747(2010).
RN [3]
RP PROBABLE FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=29391531; DOI=10.1038/s41598-018-20517-8;
RA Wahedi A., Paluzzi J.P.;
RT "Molecular identification, transcript expression, and functional
RT deorphanization of the adipokinetic hormone/corazonin-related peptide
RT receptor in the disease vector, Aedes aegypti.";
RL Sci. Rep. 8:2146-2146(2018).
CC -!- FUNCTION: Neuropeptide with neuromodulator or neurotransmitter role
CC that activates the adipokinetic hormone/corazonin-related peptide
CC receptor (ACPR) (Probable). May function in regulation of post-ecdysis
CC activities (Probable). Does not activate the A.gambiae adipokinetic
CC hormone (AKH) and corazonin (CRZ) receptors (Probable).
CC {ECO:0000305|PubMed:20068045, ECO:0000305|PubMed:29391531}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:20068045}.
CC -!- TISSUE SPECIFICITY: Only expressed in the head and thorax body segments
CC of adults. Is more expressed in adult males than in females.
CC {ECO:0000269|PubMed:29391531}.
CC -!- DEVELOPMENTAL STAGE: Much more expressed in adults than in larvae.
CC {ECO:0000269|PubMed:29391531}.
CC -!- SIMILARITY: Belongs to the AKH/HRTH/RPCH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAT37004.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CH477709; EAT37004.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_001661197.1; XM_001661147.1.
DR STRING; 7159.AAEL010950-PB; -.
DR VEuPathDB; VectorBase:AAEL010950; -.
DR eggNOG; ENOG502T1FA; Eukaryota.
DR InParanoid; Q16RI5; -.
DR OMA; QHLTMCE; -.
DR OrthoDB; 1540578at2759; -.
DR PhylomeDB; Q16RI5; -.
DR Proteomes; UP000008820; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR002047; Adipokinetic_hormone_CS.
DR InterPro; IPR010475; AKH/RPCH_hormone.
DR Pfam; PF06377; Adipokin_hormo; 1.
DR PROSITE; PS00256; AKH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PEPTIDE 26..35
FT /note="Adipokinetic hormone/corazonin-related peptide"
FT /evidence="ECO:0000305|PubMed:20068045"
FT /id="PRO_5004184941"
FT PROPEP 39..106
FT /evidence="ECO:0000305"
FT /id="PRO_0000453424"
FT SITE 38..39
FT /note="Cleavage by prohormone convertase"
FT /evidence="ECO:0000305|PubMed:20068045"
FT MOD_RES 26
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000305|PubMed:20068045"
FT MOD_RES 35
FT /note="Alanine amide"
FT /evidence="ECO:0000305|PubMed:20068045"
SQ SEQUENCE 106 AA; 11504 MW; F967ADD6694B658A CRC64;
MRNSIYKLIM FAVLCMVLTS SLSYAQVTFS RDWNAGKRSL AEAAQSTGDC AAIWRSVTNL
CAAVTKNIQH LTMCEARALM KNLQSEDASM ENNGGGGLPL FSNGHL
