ID   CSM3_PICGU              Reviewed;         210 AA.
AC   A5DDH8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Chromosome segregation in meiosis protein 3;
GN   Name=CSM3; ORFNames=PGUG_01329;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Forms a fork protection complex (FPC) with TOF1 and which is
CC       required for chromosome segregation during meiosis and DNA damage
CC       repair. FPC coordinates leading and lagging strand synthesis and moves
CC       with the replication fork. FPC stabilizes replication forks in a
CC       configuration that is recognized by replication checkpoint sensors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC       TOF1 and CSM3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR   EMBL; CH408156; EDK37231.2; -; Genomic_DNA.
DR   RefSeq; XP_001485658.1; XM_001485608.1.
DR   AlphaFoldDB; A5DDH8; -.
DR   SMR; A5DDH8; -.
DR   STRING; 4929.XP_001485658.1; -.
DR   EnsemblFungi; EDK37231; EDK37231; PGUG_01329.
DR   GeneID; 5128055; -.
DR   KEGG; pgu:PGUG_01329; -.
DR   VEuPathDB; FungiDB:PGUG_01329; -.
DR   eggNOG; KOG3004; Eukaryota.
DR   HOGENOM; CLU_1310540_0_0_1; -.
DR   InParanoid; A5DDH8; -.
DR   OrthoDB; 1442131at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0048478; P:replication fork protection; IEA:InterPro.
DR   InterPro; IPR012923; Csm3.
DR   Pfam; PF07962; Swi3; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Chromosome segregation in meiosis protein 3"
FT                   /id="PRO_0000301724"
FT   REGION          142..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   210 AA;  24725 MW;  2BBB232DFBC0B885 CRC64;
     MSDDVLGLDQ PIKLTKRTKI SKIDLDGLMD KQKGLPFIIS SYRKPLRVIE RNDQRLAAKL
     EKKDLTSSQR RRLKYDNEFQ NLQAILQFYQ LWCHGLLPKA KFRDCIYLLR SFGARDTSLK
     RYRKTLIEAE INKKKEELGL AVPSEQPSTT QEYSKSEQRV NEPDDFFSED EFYADPQDEN
     LFVRPEVPHL EDIPNESYDA EMELLREMDS