CSM3_PICST
ID CSM3_PICST Reviewed; 352 AA.
AC A3LW29;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Chromosome segregation in meiosis protein 3;
GN Name=CSM3; ORFNames=PICST_32328;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Forms a fork protection complex (FPC) with TOF1 and which is
CC required for chromosome segregation during meiosis and DNA damage
CC repair. FPC coordinates leading and lagging strand synthesis and moves
CC with the replication fork. FPC stabilizes replication forks in a
CC configuration that is recognized by replication checkpoint sensors (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the fork protection complex (FPC) consisting of
CC TOF1 and CSM3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CSM3 family. {ECO:0000305}.
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DR EMBL; CP000499; ABN67214.2; -; Genomic_DNA.
DR RefSeq; XP_001385243.2; XM_001385206.1.
DR AlphaFoldDB; A3LW29; -.
DR SMR; A3LW29; -.
DR STRING; 4924.XP_001385243.2; -.
DR EnsemblFungi; ABN67214; ABN67214; PICST_32328.
DR GeneID; 4839568; -.
DR KEGG; pic:PICST_32328; -.
DR eggNOG; KOG3004; Eukaryota.
DR HOGENOM; CLU_068092_0_0_1; -.
DR InParanoid; A3LW29; -.
DR OMA; FRADMEN; -.
DR OrthoDB; 1442131at2759; -.
DR Proteomes; UP000002258; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000076; P:DNA replication checkpoint signaling; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0048478; P:replication fork protection; IEA:InterPro.
DR InterPro; IPR012923; Csm3.
DR InterPro; IPR040038; TIPIN/Csm3/Swi3.
DR PANTHER; PTHR13220; PTHR13220; 1.
DR Pfam; PF07962; Swi3; 1.
PE 3: Inferred from homology;
KW Cell cycle; DNA damage; DNA repair; DNA replication inhibitor; Meiosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..352
FT /note="Chromosome segregation in meiosis protein 3"
FT /id="PRO_0000301725"
FT REGION 16..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 39778 MW; C16AC323741D1DA1 CRC64;
MSGFLDDYSE SLEQFESFRA DDQDVHQHIT SGEHDPVDGD SNVADAEQDD LLGLDTQIKL
TKRKPTARVD NNRIFSQKGL GYLLKNHHKL SKTIQRNDKQ FEEKSKNGRV HRAQKFQHEY
DNLSSVLQFY QLWCHGMFPK ANFKDCVHLL RLLGAKSPRL RLYRRELIEQ EIIKLKEASG
IIVEQEEREN TLQAGNIIVD AENQETEDII EASNINNVVS TETSGETNGL FVGDNDDDDL
YHTPPPPETV SPNIAVSSIV VSKPDLADIT GVSDTDTTIV DKSEVNIQPI AIPVLTQVSD
LTNTTNNESD HDAFSDDDDF YASLNETFVH QERPPQESDY DAEEEVMKEM GL
