ID   CSM4_MYCTO              Reviewed;         302 AA.
AC   P9WJF6; F2GLB4; L0TAR3; P71632; Q7D6I4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=CRISPR system Cms protein Csm4;
DE   AltName: Full=CRISPR type III-A associated RAMP protein Csm4;
GN   Name=csm4; OrderedLocusNames=MT2887;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA). The
CC       type III-A Csm effector complex binds crRNA and acts as a crRNA-guided
CC       RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA
CC       cognate to the crRNA is required for all activities.
CC       {ECO:0000250|UniProtKB:A0A0A7HGA1}.
CC   -!- FUNCTION: The subunit probably binds to the 5' handle of the crRNA,
CC       helping in discrimination between self- and non-self.
CC       {ECO:0000250|UniProtKB:A0A0A7HGA1}.
CC   -!- SUBUNIT: Part of the Csm effector complex that includes Cas10, Csm2,
CC       Csm3, Csm4 and Csm5. {ECO:0000250|UniProtKB:P9WJF7}.
CC   -!- MISCELLANEOUS: Encoded in a type III-A CRISPR locus. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated Csm4 family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK47212.1; -; Genomic_DNA.
DR   PIR; G70691; G70691.
DR   RefSeq; WP_003414288.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJF6; -.
DR   SMR; P9WJF6; -.
DR   EnsemblBacteria; AAK47212; AAK47212; MT2887.
DR   KEGG; mtc:MT2887; -.
DR   PATRIC; fig|83331.31.peg.3116; -.
DR   HOGENOM; CLU_062371_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR005510; Csm4.
DR   InterPro; IPR040932; Csm4_C.
DR   Pfam; PF17953; Csm4_C; 1.
DR   TIGRFAMs; TIGR01903; cas5_csm4; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; RNA-binding.
FT   CHAIN           1..302
FT                   /note="CRISPR system Cms protein Csm4"
FT                   /id="PRO_0000427838"
SQ   SEQUENCE   302 AA;  32301 MW;  7760E26BA3107802 CRC64;
     MNSRLFRFDF DRTHFGDHGL ESSTISCPAD TLYSALCVEA LRMGGQQLLG ELVACSTLRL
     TDLLPYVGPD YLVPKPLHSV RSDGSSMQKK LAKKIGFLPA AQLGSFLDGT ADLKELAARQ
     TKIGVHAVSA KAAIHNGKKD ADPYRVGYFR FELDAGLWLL ATGSESELGL LTRLLKGISA
     LGGERTSGFG AFNLTESEAP AALTPTVDAA SLMTLTTSLP TDDELEAALA GATYRLVKRS
     GFVASSTYAD MPLRKRDIYK FAAGSVFSRP FQGGILDVSL GGNHPVYSYA RPLFLALPES
     AA