CSM4_YEAST
ID CSM4_YEAST Reviewed; 156 AA.
AC Q08955; D6W3G9;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Chromosome segregation in meiosis protein 4;
GN Name=CSM4; OrderedLocusNames=YPL200W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION.
RX PubMed=11470404; DOI=10.1016/s0960-9822(01)00274-3;
RA Rabitsch K.P., Toth A., Galova M., Schleiffer A., Schaffner G., Aigner E.,
RA Rupp C., Penkner A.M., Moreno-Borchart A.C., Primig M., Esposito R.E.,
RA Klein F., Knop M., Nasmyth K.;
RT "A screen for genes required for meiosis and spore formation based on
RT whole-genome expression.";
RL Curr. Biol. 11:1001-1009(2001).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=12514182; DOI=10.1074/jbc.m212725200;
RA Beilharz T., Egan B., Silver P.A., Hofmann K., Lithgow T.;
RT "Bipartite signals mediate subcellular targeting of tail-anchored membrane
RT proteins in Saccharomyces cerevisiae.";
RL J. Biol. Chem. 278:8219-8223(2003).
RN [6]
RP FUNCTION, AND INTERACTION WITH MPS3.
RX PubMed=18585352; DOI=10.1016/j.cell.2008.04.047;
RA Conrad M.N., Lee C.Y., Chao G., Shinohara M., Kosaka H., Shinohara A.,
RA Conchello J.A., Dresser M.E.;
RT "Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and
RT CSM4 and is modulated by recombination.";
RL Cell 133:1175-1187(2008).
CC -!- FUNCTION: Involved in chromosome segregation during meiosis. Involved
CC in meiotic telomere clustering (bouquet formation) and telomere-led
CC rapid prophase movements. {ECO:0000269|PubMed:11470404,
CC ECO:0000269|PubMed:18585352}.
CC -!- SUBUNIT: Interacts with MPS3. {ECO:0000269|PubMed:18585352}.
CC -!- INTERACTION:
CC Q08955; P47069: MPS3; NbExp=2; IntAct=EBI-31728, EBI-25811;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:12514182}; Single-pass membrane protein
CC {ECO:0000269|PubMed:12514182}. Nucleus membrane
CC {ECO:0000305|PubMed:12514182}; Single-pass membrane protein
CC {ECO:0000305|PubMed:12514182}.
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DR EMBL; Z73556; CAA97914.1; -; Genomic_DNA.
DR EMBL; AY693044; AAT93063.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11235.1; -; Genomic_DNA.
DR PIR; S65219; S65219.
DR RefSeq; NP_015124.1; NM_001184014.1.
DR AlphaFoldDB; Q08955; -.
DR BioGRID; 35984; 27.
DR DIP; DIP-3974N; -.
DR IntAct; Q08955; 1.
DR STRING; 4932.YPL200W; -.
DR PaxDb; Q08955; -.
DR PRIDE; Q08955; -.
DR EnsemblFungi; YPL200W_mRNA; YPL200W; YPL200W.
DR GeneID; 855901; -.
DR KEGG; sce:YPL200W; -.
DR SGD; S000006121; CSM4.
DR VEuPathDB; FungiDB:YPL200W; -.
DR HOGENOM; CLU_1696881_0_0_1; -.
DR OMA; WKEMIAF; -.
DR BioCyc; YEAST:G3O-34092-MON; -.
DR PRO; PR:Q08955; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q08955; protein.
DR GO; GO:0000781; C:chromosome, telomeric region; IDA:SGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IMP:SGD.
DR GO; GO:0005640; C:nuclear outer membrane; IDA:SGD.
DR GO; GO:0140444; F:cytoskeleton-nuclear membrane anchor activity; IMP:SGD.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:SGD.
DR GO; GO:0045132; P:meiotic chromosome segregation; IMP:SGD.
DR GO; GO:0045141; P:meiotic telomere clustering; IMP:SGD.
DR GO; GO:0010520; P:regulation of reciprocal meiotic recombination; IMP:SGD.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Chromosome partition; Endoplasmic reticulum; Meiosis; Membrane; Nucleus;
KW Reference proteome; Sporulation; Transmembrane; Transmembrane helix.
FT CHAIN 1..156
FT /note="Chromosome segregation in meiosis protein 4"
FT /id="PRO_0000079404"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 156 AA; 18307 MW; 20386CDD5C39D11F CRC64;
MMDGSITRKV TSTLSNQLAT WKWKLQLSLL ERKLATINND YFLLQWELLF ITNEVMKWKE
MIAFLESQLF CTTQNFVAQE THDRETFQSL VDDYNKQLSE NNLIISVLKS RPQLSSFPIY
LSDEVCSHLK FVIAELNSLI IVFFISLVFL WVSIEV
