ID   CSM5_METJA              Reviewed;         418 AA.
AC   Q59061;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=CRISPR system Cms protein Csm5;
DE   AltName: Full=CRISPR type III A-associated protein Csm5;
GN   Name=csm5; OrderedLocusNames=MJ1667;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC       repeat) is an adaptive immune system that provides protection against
CC       mobile genetic elements (viruses, transposable elements and conjugative
CC       plasmids). CRISPR clusters contain spacers, sequences complementary to
CC       antecedent mobile elements, and target invading nucleic acids. CRISPR
CC       clusters are transcribed and processed into CRISPR RNA (crRNA). The
CC       type III-A Csm effector complex binds crRNA and acts as a crRNA-guided
CC       RNase, DNase and cyclic oligoadenylate synthase; binding of target RNA
CC       cognate to the crRNA is required for all activities.
CC       {ECO:0000250|UniProtKB:A0A0A7HF79}.
CC   -!- FUNCTION: This subunit might be involved in maturation of a crRNA
CC       intermediate to its mature form. {ECO:0000250|UniProtKB:A0A0A7HF79}.
CC   -!- SUBUNIT: Part of the Csm effector complex that includes Cas10, Csm2,
CC       Csm3, Csm4 and Csm5. {ECO:0000250|UniProtKB:A0A0A7HF79}.
CC   -!- MISCELLANEOUS: Encoded in a type III-A CRISPR locus. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRISPR-associated Csm5 family.
CC       {ECO:0000305}.
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DR   EMBL; L77117; AAB99692.1; -; Genomic_DNA.
DR   PIR; A64508; A64508.
DR   AlphaFoldDB; Q59061; -.
DR   STRING; 243232.MJ_1667; -.
DR   PRIDE; Q59061; -.
DR   EnsemblBacteria; AAB99692; AAB99692; MJ_1667.
DR   KEGG; mja:MJ_1667; -.
DR   eggNOG; arCOG03718; Archaea.
DR   HOGENOM; CLU_036878_3_0_2; -.
DR   InParanoid; Q59061; -.
DR   OMA; PIFIGCG; -.
DR   PhylomeDB; Q59061; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR010173; CRISPR-assoc_Csm5.
DR   InterPro; IPR005537; RAMP_III_fam.
DR   PANTHER; PTHR38007; PTHR38007; 1.
DR   Pfam; PF03787; RAMPs; 1.
DR   TIGRFAMs; TIGR01899; cas_TM1807_csm5; 1.
PE   3: Inferred from homology;
KW   Antiviral defense; Reference proteome; RNA-binding.
FT   CHAIN           1..418
FT                   /note="CRISPR system Cms protein Csm5"
FT                   /id="PRO_0000107464"
SQ   SEQUENCE   418 AA;  48804 MW;  14C31107463948D2 CRC64;
     MLKTYPLKMM MTSRIRIMKT TINLIIRSIP MENQYYSHLI QRGITMEVKC ELITPIFIGC
     GEEYSQLDYF IEDGLAHIID LEKAVSDLDD LEKVDYISGL IVSNIDNNRL NLTAKDILES
     VGLNPYDYVI RKIESEIFSN KKTRVKKFIN QNNTYYIPGS SIKGAIRTAY IFNYYDKNLP
     ELLKILDDRN IKLHDKGKEL EKNAISKDIP KDFFKYLKIS DSLNLEGEFK FIHTKRWNYR
     KKKFDVPINM EGMTKGTFSI NIKIEDEFFK NINKRLKTNY NPKDDEKKFD ILKNLCNNFS
     KTVVEFELKK NNPVYVEKSY EKLLADINKD DAIYLNLGFG GGFLNKTVYP LLWKNDENHL
     YFRKIKSLFI ALSGGNKNLK NAWLKANSYL DFPTTKTVYV KNNSAIAPLG WIKMTLVE