CSMD1_HUMAN
ID CSMD1_HUMAN Reviewed; 3564 AA.
AC Q96PZ7; A0A0U1RQY1; Q0H0J5; Q96QU9; Q96RM4;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=CUB and sushi domain-containing protein 1;
DE AltName: Full=CUB and sushi multiple domains protein 1;
DE Flags: Precursor;
GN Name=CSMD1; Synonyms=KIAA1890; ORFNames=UNQ5952/PRO19863;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=11472063; DOI=10.1006/geno.2001.6587;
RA Sun P.C., Uppaluri R., Schmidt A.P., Pashia M.E., Quant E.C., Sunwoo J.B.,
RA Gollin S.M., Scholnick S.B.;
RT "Transcript map of the 8p23 putative tumor suppressor region.";
RL Genomics 75:17-25(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 140-203.
RX PubMed=16751668; DOI=10.1534/genetics.106.055715;
RA Bubb K.L., Bovee D., Buckley D., Haugen E., Kibukawa M., Paddock M.,
RA Palmieri A., Subramanian S., Zhou Y., Kaul R., Green P., Olson M.V.;
RT "Scan of human genome reveals no new loci under ancient balancing
RT selection.";
RL Genetics 173:2165-2177(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 824-3564 (ISOFORM 4).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 965-2012 (ISOFORM 4), AND TISSUE
RP SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1318-3564 (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP CANDIDATE FOR OSCCS.
RX PubMed=12696061; DOI=10.1002/gcc.10191;
RA Toomes C., Jackson A., Maguire K., Wood J., Gollin S., Ishwad C.,
RA Paterson I., Prime S., Parkinson K., Bell S., Woods G., Markham A.,
RA Oliver R., Woodward R., Sloan P., Dixon M., Read A., Thakker N.;
RT "The presence of multiple regions of homozygous deletion at the CSMD1 locus
RT in oral squamous cell carcinoma question the role of CSMD1 in head and neck
RT carcinogenesis.";
RL Genes Chromosomes Cancer 37:132-140(2003).
RN [8]
RP CANDIDATE FOR OSCCS.
RX PubMed=14506705; DOI=10.1002/gcc.10279;
RA Scholnick S.B., Richter T.M.;
RT "The role of CSMD1 in head and neck carcinogenesis.";
RL Genes Chromosomes Cancer 38:281-283(2003).
RN [9]
RP STRUCTURE BY NMR OF 521-580.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the third sushi domain from human CUB and sushi
RT domain-containing protein 1.";
RL Submitted (SEP-2007) to the PDB data bank.
RN [10]
RP VARIANTS ALA-2260 AND CYS-3539.
RX PubMed=26566883; DOI=10.1136/jmedgenet-2015-103179;
RA Rafiullah R., Aslamkhan M., Paramasivam N., Thiel C., Mustafa G.,
RA Wiemann S., Schlesner M., Wade R.C., Rappold G.A., Berkel S.;
RT "Homozygous missense mutation in the LMAN2L gene segregates with
RT intellectual disability in a large consanguineous Pakistani family.";
RL J. Med. Genet. 53:138-144(2016).
CC -!- FUNCTION: Potential suppressor of squamous cell carcinomas.
CC -!- INTERACTION:
CC Q96PZ7; P84022: SMAD3; NbExp=3; IntAct=EBI-766158, EBI-347161;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96PZ7-1; Sequence=Displayed;
CC Name=2; Synonyms=Short;
CC IsoId=Q96PZ7-2; Sequence=VSP_009034, VSP_009035;
CC Name=3;
CC IsoId=Q96PZ7-3; Sequence=VSP_009030, VSP_009031;
CC Name=4;
CC IsoId=Q96PZ7-4; Sequence=VSP_009032, VSP_009033;
CC -!- TISSUE SPECIFICITY: Weakly expressed in most tissues, except in brain.
CC Expressed at intermediate level in brain, including cerebellum,
CC substantia nigra, hippocampus and fetal brain.
CC {ECO:0000269|PubMed:11572484}.
CC -!- MISCELLANEOUS: CSMD1 may be a candidate for oral and oropharyngeal
CC squamous cell carcinomas (OSCCs). PubMed:12696061 and PubMed:14506705
CC are however in disagreement: while PubMed:14506705 considers CSMD1 as a
CC strong candidate for OSCCs, PubMed:12696061 thinks it is not.
CC -!- SIMILARITY: Belongs to the CSMD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ88541.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF333704; AAK73475.2; -; mRNA.
DR EMBL; AC021523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC023296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC087692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC026991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY017307; AAG52948.1; -; mRNA.
DR EMBL; DQ384438; ABD48881.1; -; Genomic_DNA.
DR EMBL; DQ384439; ABD48882.1; -; Genomic_DNA.
DR EMBL; DQ384440; ABD48883.1; -; Genomic_DNA.
DR EMBL; DQ384441; ABD48884.1; -; Genomic_DNA.
DR EMBL; DQ384442; ABD48885.1; -; Genomic_DNA.
DR EMBL; KF458667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY358174; AAQ88541.1; ALT_INIT; mRNA.
DR EMBL; AB067477; BAB67783.1; -; mRNA.
DR EMBL; AK126936; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS55189.1; -. [Q96PZ7-1]
DR RefSeq; NP_150094.5; NM_033225.5. [Q96PZ7-1]
DR PDB; 2EHF; NMR; -; A=521-580.
DR PDBsum; 2EHF; -.
DR SMR; Q96PZ7; -.
DR BioGRID; 122185; 6.
DR IntAct; Q96PZ7; 4.
DR MINT; Q96PZ7; -.
DR STRING; 9606.ENSP00000430733; -.
DR GlyGen; Q96PZ7; 40 sites.
DR iPTMnet; Q96PZ7; -.
DR PhosphoSitePlus; Q96PZ7; -.
DR BioMuta; CSMD1; -.
DR DMDM; 38604975; -.
DR MassIVE; Q96PZ7; -.
DR PaxDb; Q96PZ7; -.
DR PeptideAtlas; Q96PZ7; -.
DR PRIDE; Q96PZ7; -.
DR ProteomicsDB; 77795; -. [Q96PZ7-1]
DR ProteomicsDB; 77796; -. [Q96PZ7-2]
DR ProteomicsDB; 77797; -. [Q96PZ7-3]
DR ProteomicsDB; 77798; -. [Q96PZ7-4]
DR Antibodypedia; 52810; 83 antibodies from 20 providers.
DR DNASU; 64478; -.
DR Ensembl; ENST00000635120.2; ENSP00000489225.1; ENSG00000183117.20. [Q96PZ7-1]
DR GeneID; 64478; -.
DR KEGG; hsa:64478; -.
DR MANE-Select; ENST00000635120.2; ENSP00000489225.1; NM_033225.6; NP_150094.5.
DR CTD; 64478; -.
DR DisGeNET; 64478; -.
DR GeneCards; CSMD1; -.
DR HGNC; HGNC:14026; CSMD1.
DR HPA; ENSG00000183117; Tissue enhanced (brain, testis).
DR MIM; 608397; gene.
DR neXtProt; NX_Q96PZ7; -.
DR OpenTargets; ENSG00000183117; -.
DR PharmGKB; PA26947; -.
DR VEuPathDB; HostDB:ENSG00000183117; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000155701; -.
DR InParanoid; Q96PZ7; -.
DR PhylomeDB; Q96PZ7; -.
DR PathwayCommons; Q96PZ7; -.
DR SignaLink; Q96PZ7; -.
DR SIGNOR; Q96PZ7; -.
DR BioGRID-ORCS; 64478; 8 hits in 1075 CRISPR screens.
DR ChiTaRS; CSMD1; human.
DR EvolutionaryTrace; Q96PZ7; -.
DR GeneWiki; CSMD1; -.
DR GenomeRNAi; 64478; -.
DR Pharos; Q96PZ7; Tbio.
DR PRO; PR:Q96PZ7; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96PZ7; protein.
DR Bgee; ENSG00000183117; Expressed in Brodmann (1909) area 23 and 143 other tissues.
DR ExpressionAtlas; Q96PZ7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:1990708; P:conditioned place preference; IEA:Ensembl.
DR GO; GO:0008585; P:female gonad development; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0060745; P:mammary gland branching involved in pregnancy; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0035846; P:oviduct epithelium development; IEA:Ensembl.
DR GO; GO:0001964; P:startle response; IEA:Ensembl.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.60.120.290; -; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 28.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF49854; SSF49854; 14.
DR SUPFAM; SSF57535; SSF57535; 28.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 28.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Disulfide bond; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Sushi; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..3564
FT /note="CUB and sushi domain-containing protein 1"
FT /id="PRO_0000021025"
FT TOPO_DOM 27..3487
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 3488..3508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 3509..3564
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..140
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 143..204
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 208..312
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 347..408
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 411..522
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 525..582
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 584..692
FT /note="CUB 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 695..756
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 758..866
FT /note="CUB 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 871..928
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 930..1040
FT /note="CUB 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1043..1102
FT /note="Sushi 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1104..1212
FT /note="CUB 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1215..1275
FT /note="Sushi 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1277..1386
FT /note="CUB 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1389..1449
FT /note="Sushi 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1451..1559
FT /note="CUB 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1562..1623
FT /note="Sushi 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1625..1733
FT /note="CUB 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1739..1800
FT /note="Sushi 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1802..1910
FT /note="CUB 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1913..1972
FT /note="Sushi 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1974..2082
FT /note="CUB 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2085..2144
FT /note="Sushi 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2146..2257
FT /note="CUB 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2256..2317
FT /note="Sushi 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2319..2430
FT /note="CUB 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2430..2492
FT /note="Sushi 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2493..2554
FT /note="Sushi 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2555..2619
FT /note="Sushi 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2620..2677
FT /note="Sushi 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2678..2735
FT /note="Sushi 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2736..2793
FT /note="Sushi 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2794..2856
FT /note="Sushi 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2857..2914
FT /note="Sushi 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2918..2975
FT /note="Sushi 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2976..3034
FT /note="Sushi 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3035..3094
FT /note="Sushi 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3095..3152
FT /note="Sushi 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3153..3210
FT /note="Sushi 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3214..3272
FT /note="Sushi 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3273..3332
FT /note="Sushi 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 587
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 686
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 955
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1015
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1034
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1399
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1454
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1572
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1644
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1792
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1805
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1882
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2018
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2358
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2445
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2470
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2503
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2605
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2750
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2761
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2795
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2894
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2963
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3022
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3056
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3260
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3379
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3386
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..58
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 145..185
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 171..202
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 208..234
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 349..389
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 375..406
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 411..437
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 527..567
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 553..580
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 584..610
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 697..738
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 723..754
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 758..784
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 873..913
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 899..926
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 930..956
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1045..1085
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1071..1100
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1104..1130
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1217..1258
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1244..1273
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1277..1304
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1391..1431
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1417..1447
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1451..1477
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1564..1604
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1590..1621
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1625..1651
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1741..1781
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1767..1798
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1802..1828
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 1915..1955
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1941..1970
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 1974..2000
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2087..2127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2113..2142
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2146..2172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2258..2300
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2286..2315
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2319..2347
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DISULFID 2432..2473
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2459..2490
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2495..2537
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2521..2552
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2557..2602
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2588..2617
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2622..2662
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2648..2675
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2680..2720
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2706..2733
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2738..2778
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2764..2791
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2796..2841
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2827..2854
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2859..2899
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2885..2912
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2920..2960
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2946..2973
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 2978..3019
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3005..3032
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3037..3079
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3063..3092
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3097..3137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3123..3150
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3155..3195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3181..3208
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3216..3257
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3243..3270
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3275..3317
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DISULFID 3302..3330
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT VAR_SEQ 2012
FT /note="A -> K (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11572484,
FT ECO:0000303|PubMed:12975309"
FT /id="VSP_009032"
FT VAR_SEQ 2013..3564
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11572484,
FT ECO:0000303|PubMed:12975309"
FT /id="VSP_009033"
FT VAR_SEQ 2081..2109
FT /note="AYELQNCPDPPPFQNGYMINSDYSVGQSV -> GGSGNIGPAFPCLDTPFQA
FT RCQGEERTFN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009030"
FT VAR_SEQ 2110..3564
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009031"
FT VAR_SEQ 2619..2676
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11472063"
FT /id="VSP_009034"
FT VAR_SEQ 2975..3093
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11472063"
FT /id="VSP_009035"
FT VARIANT 2040
FT /note="M -> I (in dbSNP:rs6995799)"
FT /id="VAR_059634"
FT VARIANT 2260
FT /note="P -> A (in dbSNP:rs1254099921)"
FT /evidence="ECO:0000269|PubMed:26566883"
FT /id="VAR_076444"
FT VARIANT 3311
FT /note="G -> W (in dbSNP:rs34079122)"
FT /id="VAR_056846"
FT VARIANT 3369
FT /note="Q -> H (in dbSNP:rs34337712)"
FT /id="VAR_059635"
FT VARIANT 3478
FT /note="S -> N (in dbSNP:rs11984691)"
FT /id="VAR_059636"
FT VARIANT 3539
FT /note="Y -> C (in dbSNP:rs573209145)"
FT /evidence="ECO:0000269|PubMed:26566883"
FT /id="VAR_076445"
FT CONFLICT 82
FT /note="D -> N (in Ref. 1; AAK73475/AAG52948)"
FT /evidence="ECO:0000305"
FT CONFLICT 347..350
FT /note="DMCP -> HMCL (in Ref. 1; AAK73475/AAG52948)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="F -> FS (in Ref. 1; AAK73475/AAG52948)"
FT /evidence="ECO:0000305"
FT CONFLICT 643
FT /note="D -> N (in Ref. 1; AAG52948)"
FT /evidence="ECO:0000305"
FT CONFLICT 798
FT /note="I -> M (in Ref. 1; AAK73475/AAG52948)"
FT /evidence="ECO:0000305"
FT CONFLICT 1461
FT /note="V -> I (in Ref. 6; AK126936)"
FT /evidence="ECO:0000305"
FT CONFLICT 1842..1856
FT /note="IQVISFATEQNWDSL -> DPSDQFCHGAELGLPF (in Ref. 1;
FT AAK73475/AAG52948)"
FT /evidence="ECO:0000305"
FT CONFLICT 2061
FT /note="L -> F (in Ref. 6; AK126936)"
FT /evidence="ECO:0000305"
FT CONFLICT 2551
FT /note="T -> M (in Ref. 1; AAK73475/AAG52948)"
FT /evidence="ECO:0000305"
FT CONFLICT 2832
FT /note="Y -> H (in Ref. 1; AAK73475)"
FT /evidence="ECO:0000305"
FT STRAND 534..539
FT /evidence="ECO:0007829|PDB:2EHF"
FT STRAND 548..552
FT /evidence="ECO:0007829|PDB:2EHF"
FT STRAND 563..567
FT /evidence="ECO:0007829|PDB:2EHF"
FT STRAND 569..575
FT /evidence="ECO:0007829|PDB:2EHF"
SQ SEQUENCE 3564 AA; 388736 MW; 949BAAF5DD559A0C CRC64;
MTAWRRFQSL LLLLGLLVLC ARLLTAAKGQ NCGGLVQGPN GTIESPGFPH GYPNYANCTW
IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV RLSGFQLPSS IVSTGSILTL
WFTTDFAVSA QGFKALYEVL PSHTCGNPGE ILKGVLHGTR FNIGDKIRYS CLPGYILEGH
AILTCIVSPG NGASWDFPAP FCRAEGACGG TLRGTSSSIS SPHFPSEYEN NADCTWTILA
EPGDTIALVF TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH
RRKGFNAQFQ VKKAIELKSR GVKMLPSKDG SHKNSVLSQG GVALVSDMCP DPGIPENGRR
AGSDFRVGAN VQFSCEDNYV LQGSKSITCQ RVTETLAAWS DHRPICRART CGSNLRGPSG
VITSPNYPVQ YEDNAHCVWV ITTTDPDKVI KLAFEEFELE RGYDTLTVGD AGKVGDTRSV
LYVLTGSSVP DLIVSMSNQM WLHLQSDDSI GSPGFKAVYQ EIEKGGCGDP GIPAYGKRTG
SSFLHGDTLT FECPAAFELV GERVITCQQN NQWSGNKPSC VFSCFFNFTA SSGIILSPNY
PEEYGNNMNC VWLIISEPGS RIHLIFNDFD VEPQFDFLAV KDDGISDITV LGTFSGNEVP
SQLASSGHIV RLEFQSDHST TGRGFNITYT TFGQNECHDP GIPINGRRFG DRFLLGSSVS
FHCDDGFVKT QGSESITCIL QDGNVVWSST VPRCEAPCGG HLTASSGVIL PPGWPGYYKD
SLHCEWIIEA KPGHSIKITF DRFQTEVNYD TLEVRDGPAS SSPLIGEYHG TQAPQFLIST
GNFMYLLFTT DNSRSSIGFL IHYESVTLES DSCLDPGIPV NGHRHGGDFG IRSTVTFSCD
PGYTLSDDEP LVCERNHQWN HALPSCDALC GGYIQGKSGT VLSPGFPDFY PNSLNCTWTI
EVSHGKGVQM IFHTFHLESS HDYLLITEDG SFSEPVARLT GSVLPHTIKA GLFGNFTAQL
RFISDFSISY EGFNITFSEY DLEPCDDPGV PAFSRRIGFH FGVGDSLTFS CFLGYRLEGA
TKLTCLGGGR RVWSAPLPRC VAECGASVKG NEGTLLSPNF PSNYDNNHEC IYKIETEAGK
GIHLRTRSFQ LFEGDTLKVY DGKDSSSRPL GTFTKNELLG LILNSTSNHL WLEFNTNGSD
TDQGFQLTYT SFDLVKCEDP GIPNYGYRIR DEGHFTDTVV LYSCNPGYAM HGSNTLTCLS
GDRRVWDKPL PSCIAECGGQ IHAATSGRIL SPGYPAPYDN NLHCTWIIEA DPGKTISLHF
IVFDTEMAHD ILKVWDGPVD SDILLKEWSG SALPEDIHST FNSLTLQFDS DFFISKSGFS
IQFSTSIAAT CNDPGMPQNG TRYGDSREAG DTVTFQCDPG YQLQGQAKIT CVQLNNRFFW
QPDPPTCIAA CGGNLTGPAG VILSPNYPQP YPPGKECDWR VKVNPDFVIA LIFKSFNMEP
SYDFLHIYEG EDSNSPLIGS YQGSQAPERI ESSGNSLFLA FRSDASVGLS GFAIEFKEKP
REACFDPGNI MNGTRVGTDF KLGSTITYQC DSGYKILDPS SITCVIGADG KPSWDQVLPS
CNAPCGGQYT GSEGVVLSPN YPHNYTAGQI CLYSITVPKE FVVFGQFAYF QTALNDLAEL
FDGTHAQARL LSSLSGSHSG ETLPLATSNQ ILLRFSAKSG ASARGFHFVY QAVPRTSDTQ
CSSVPEPRYG RRIGSEFSAG SIVRFECNPG YLLQGSTALH CQSVPNALAQ WNDTIPSCVV
PCSGNFTQRR GTILSPGYPE PYGNNLNCIW KIIVTEGSGI QIQVISFATE QNWDSLEIHD
GGDVTAPRLG SFSGTTVPAL LNSTSNQLYL HFQSDISVAA AGFHLEYKTV GLAACQEPAL
PSNSIKIGDR YMVNDVLSFQ CEPGYTLQGR SHISCMPGTV RRWNYPSPLC IATCGGTLST
LGGVILSPGF PGSYPNNLDC TWRISLPIGY GAHIQFLNFS TEANHDFLEI QNGPYHTSPM
IGQFSGTDLP AALLSTTHET LIHFYSDHSQ NRQGFKLAYQ AYELQNCPDP PPFQNGYMIN
SDYSVGQSVS FECYPGYILI GHPVLTCQHG INRNWNYPFP RCDAPCGYNV TSQNGTIYSP
GFPDEYPILK DCIWLITVPP GHGVYINFTL LQTEAVNDYI AVWDGPDQNS PQLGVFSGNT
ALETAYSSTN QVLLKFHSDF SNGGFFVLNF HAFQLKKCQP PPAVPQAEML TEDDDFEIGD
FVKYQCHPGY TLVGTDILTC KLSSQLQFEG SLPTCEAQCP ANEVRTGSSG VILSPGYPGN
YFNSQTCSWS IKVEPNYNIT IFVDTFQSEK QFDALEVFDG SSGQSPLLVV LSGNHTEQSN
FTSRSNQLYL RWSTDHATSK KGFKIRYAAP YCSLTHPLKN GGILNRTAGA VGSKVHYFCK
PGYRMVGHSN ATCRRNPLGM YQWDSLTPLC QAVSCGIPES PGNGSFTGNE FTLDSKVVYE
CHEGFKLESS QQATAVCQED GLWSNKGKPP TCKPVACPSI EAQLSEHVIW RLVSGSLNEY
GAQVLLSCSP GYYLEGWRLL RCQANGTWNI GDERPSCRVI SCGSLSFPPN GNKIGTLTVY
GATAIFTCNT GYTLVGSHVR ECLANGLWSG SETRCLAGHC GSPDPIVNGH ISGDGFSYRD
TVVYQCNPGF RLVGTSVRIC LQDHKWSGQT PVCVPITCGH PGNPAHGFTN GSEFNLNDVV
NFTCNTGYLL QGVSRAQCRS NGQWSSPLPT CRVVNCSDPG FVENAIRHGQ QNFPESFEYG
MSILYHCKKG FYLLGSSALT CMANGLWDRS LPKCLAISCG HPGVPANAVL TGELFTYGAV
VHYSCRGSES LIGNDTRVCQ EDSHWSGALP HCTGNNPGFC GDPGTPAHGS RLGDDFKTKS
LLRFSCEMGH QLRGSPERTC LLNGSWSGLQ PVCEAVSCGN PGTPTNGMIV SSDGILFSSS
VIYACWEGYK TSGLMTRHCT ANGTWTGTAP DCTIISCGDP GTLANGIQFG TDFTFNKTVS
YQCNPGYVME AVTSATIRCT KDGRWNPSKP VCKAVLCPQP PPVQNGTVEG SDFRWGSSIS
YSCMDGYQLS HSAILSCEGR GVWKGEIPQC LPVFCGDPGI PAEGRLSGKS FTYKSEVFFQ
CKSPFILVGS SRRVCQADGT WSGIQPTCID PAHNTCPDPG TPHFGIQNSS RGYEVGSTVF
FRCRKGYHIQ GSTTRTCLAN LTWSGIQTEC IPHACRQPET PAHADVRAID LPTFGYTLVY
TCHPGFFLAG GSEHRTCKAD MKWTGKSPVC KSKGVREVNE TVTKTPVPSD VFFVNSLWKG
YYEYLGKRQP ATLTVDWFNA TSSKVNATFS EASPVELKLT GIYKKEEAHL LLKAFQIKGQ
ADIFVSKFEN DNWGLDGYVS SGLERGGFTF QGDIHGKDFG KFKLERQDPL NPDQDSSSHY
HGTSSGSVAA AILVPFFALI LSGFAFYLYK HRTRPKVQYN GYAGHENSNG QASFENPMYD
TNLKPTEAKA VRFDTTLNTV CTVV
