CSMD1_MOUSE
ID CSMD1_MOUSE Reviewed; 3564 AA.
AC Q923L3; E9QK23; Q8BUV1; Q8BYQ3;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=CUB and sushi domain-containing protein 1;
DE AltName: Full=CUB and sushi multiple domains protein 1;
DE Flags: Precursor;
GN Name=Csmd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J;
RX PubMed=11472063; DOI=10.1006/geno.2001.6587;
RA Sun P.C., Uppaluri R., Schmidt A.P., Pashia M.E., Quant E.C., Sunwoo J.B.,
RA Gollin S.M., Scholnick S.B.;
RT "Transcript map of the 8p23 putative tumor suppressor region.";
RL Genomics 75:17-25(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 3250-3564 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q923L3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q923L3-2; Sequence=VSP_009037;
CC Name=3;
CC IsoId=Q923L3-3; Sequence=VSP_009036;
CC -!- SIMILARITY: Belongs to the CSMD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC30095.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY017475; AAG54083.1; -; mRNA.
DR EMBL; AK038679; BAC30095.1; ALT_INIT; mRNA.
DR EMBL; AK082377; BAC38482.1; -; mRNA.
DR EMBL; AC101229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC123819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC123866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC123984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC124351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC125132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC125354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC144939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC154107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS40244.1; -. [Q923L3-1]
DR RefSeq; NP_444401.2; NM_053171.2. [Q923L3-1]
DR SMR; Q923L3; -.
DR STRING; 10090.ENSMUSP00000080751; -.
DR GlyConnect; 2241; 6 N-Linked glycans (9 sites).
DR GlyGen; Q923L3; 40 sites, 6 N-linked glycans (9 sites).
DR iPTMnet; Q923L3; -.
DR PhosphoSitePlus; Q923L3; -.
DR jPOST; Q923L3; -.
DR MaxQB; Q923L3; -.
DR PaxDb; Q923L3; -.
DR PeptideAtlas; Q923L3; -.
DR PRIDE; Q923L3; -.
DR ProteomicsDB; 285323; -. [Q923L3-1]
DR ProteomicsDB; 285324; -. [Q923L3-2]
DR Antibodypedia; 52810; 83 antibodies from 20 providers.
DR DNASU; 94109; -.
DR Ensembl; ENSMUST00000082104; ENSMUSP00000080751; ENSMUSG00000060924. [Q923L3-1]
DR GeneID; 94109; -.
DR KEGG; mmu:94109; -.
DR UCSC; uc009kzp.1; mouse. [Q923L3-1]
DR UCSC; uc009kzr.1; mouse. [Q923L3-3]
DR CTD; 64478; -.
DR MGI; MGI:2137383; Csmd1.
DR VEuPathDB; HostDB:ENSMUSG00000060924; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000155701; -.
DR HOGENOM; CLU_000277_0_0_1; -.
DR InParanoid; Q923L3; -.
DR OMA; DLVNFTC; -.
DR OrthoDB; 2377at2759; -.
DR PhylomeDB; Q923L3; -.
DR TreeFam; TF316872; -.
DR BioGRID-ORCS; 94109; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Csmd1; mouse.
DR PRO; PR:Q923L3; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q923L3; protein.
DR Bgee; ENSMUSG00000060924; Expressed in lumbar dorsal root ganglion and 65 other tissues.
DR Genevisible; Q923L3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:1990708; P:conditioned place preference; IMP:MGI.
DR GO; GO:0008585; P:female gonad development; IMP:MGI.
DR GO; GO:0042593; P:glucose homeostasis; IMP:MGI.
DR GO; GO:0008584; P:male gonad development; IMP:MGI.
DR GO; GO:0060745; P:mammary gland branching involved in pregnancy; IMP:MGI.
DR GO; GO:0007613; P:memory; IMP:MGI.
DR GO; GO:0035846; P:oviduct epithelium development; IGI:MGI.
DR GO; GO:0001964; P:startle response; IMP:MGI.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.60.120.290; -; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 28.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF49854; SSF49854; 14.
DR SUPFAM; SSF57535; SSF57535; 28.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 28.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Membrane;
KW Reference proteome; Repeat; Signal; Sushi; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..3564
FT /note="CUB and sushi domain-containing protein 1"
FT /id="PRO_0000021026"
FT TOPO_DOM 30..3487
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 3488..3508
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 3509..3564
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..140
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 143..204
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 208..312
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 347..408
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 411..522
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 525..582
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 584..692
FT /note="CUB 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 695..756
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 758..866
FT /note="CUB 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 871..928
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 930..1040
FT /note="CUB 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1043..1102
FT /note="Sushi 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1104..1212
FT /note="CUB 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1215..1275
FT /note="Sushi 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1277..1386
FT /note="CUB 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1389..1449
FT /note="Sushi 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1451..1559
FT /note="CUB 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1562..1623
FT /note="Sushi 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1625..1733
FT /note="CUB 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1739..1800
FT /note="Sushi 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1802..1910
FT /note="CUB 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1913..1972
FT /note="Sushi 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1974..2082
FT /note="CUB 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2085..2144
FT /note="Sushi 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2146..2257
FT /note="CUB 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2256..2317
FT /note="Sushi 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2319..2430
FT /note="CUB 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2430..2492
FT /note="Sushi 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2493..2554
FT /note="Sushi 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2555..2619
FT /note="Sushi 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2620..2677
FT /note="Sushi 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2678..2735
FT /note="Sushi 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2736..2793
FT /note="Sushi 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2794..2856
FT /note="Sushi 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2857..2914
FT /note="Sushi 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2918..2975
FT /note="Sushi 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2976..3034
FT /note="Sushi 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3035..3094
FT /note="Sushi 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3095..3152
FT /note="Sushi 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3153..3210
FT /note="Sushi 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3214..3272
FT /note="Sushi 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3273..3332
FT /note="Sushi 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 587
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 686
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 955
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1015
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1034
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1399
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1454
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1572
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1644
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1792
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1805
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1882
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2018
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2358
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2445
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2470
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2503
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2605
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2750
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2761
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2795
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2894
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2963
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3022
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3056
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3086
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3260
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3379
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3386
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..58
FT /evidence="ECO:0000250"
FT DISULFID 145..185
FT /evidence="ECO:0000250"
FT DISULFID 171..202
FT /evidence="ECO:0000250"
FT DISULFID 208..234
FT /evidence="ECO:0000250"
FT DISULFID 349..389
FT /evidence="ECO:0000250"
FT DISULFID 375..406
FT /evidence="ECO:0000250"
FT DISULFID 411..437
FT /evidence="ECO:0000250"
FT DISULFID 527..567
FT /evidence="ECO:0000250"
FT DISULFID 553..580
FT /evidence="ECO:0000250"
FT DISULFID 584..610
FT /evidence="ECO:0000250"
FT DISULFID 697..738
FT /evidence="ECO:0000250"
FT DISULFID 723..754
FT /evidence="ECO:0000250"
FT DISULFID 758..784
FT /evidence="ECO:0000250"
FT DISULFID 873..913
FT /evidence="ECO:0000250"
FT DISULFID 899..926
FT /evidence="ECO:0000250"
FT DISULFID 930..956
FT /evidence="ECO:0000250"
FT DISULFID 1045..1085
FT /evidence="ECO:0000250"
FT DISULFID 1071..1100
FT /evidence="ECO:0000250"
FT DISULFID 1104..1130
FT /evidence="ECO:0000250"
FT DISULFID 1217..1258
FT /evidence="ECO:0000250"
FT DISULFID 1244..1273
FT /evidence="ECO:0000250"
FT DISULFID 1277..1304
FT /evidence="ECO:0000250"
FT DISULFID 1391..1431
FT /evidence="ECO:0000250"
FT DISULFID 1417..1447
FT /evidence="ECO:0000250"
FT DISULFID 1451..1477
FT /evidence="ECO:0000250"
FT DISULFID 1564..1604
FT /evidence="ECO:0000250"
FT DISULFID 1590..1621
FT /evidence="ECO:0000250"
FT DISULFID 1625..1651
FT /evidence="ECO:0000250"
FT DISULFID 1741..1781
FT /evidence="ECO:0000250"
FT DISULFID 1767..1798
FT /evidence="ECO:0000250"
FT DISULFID 1802..1828
FT /evidence="ECO:0000250"
FT DISULFID 1915..1955
FT /evidence="ECO:0000250"
FT DISULFID 1941..1970
FT /evidence="ECO:0000250"
FT DISULFID 1974..2000
FT /evidence="ECO:0000250"
FT DISULFID 2087..2127
FT /evidence="ECO:0000250"
FT DISULFID 2113..2142
FT /evidence="ECO:0000250"
FT DISULFID 2146..2172
FT /evidence="ECO:0000250"
FT DISULFID 2258..2300
FT /evidence="ECO:0000250"
FT DISULFID 2286..2315
FT /evidence="ECO:0000250"
FT DISULFID 2319..2347
FT /evidence="ECO:0000250"
FT DISULFID 2432..2473
FT /evidence="ECO:0000250"
FT DISULFID 2459..2490
FT /evidence="ECO:0000250"
FT DISULFID 2495..2537
FT /evidence="ECO:0000250"
FT DISULFID 2521..2552
FT /evidence="ECO:0000250"
FT DISULFID 2557..2602
FT /evidence="ECO:0000250"
FT DISULFID 2588..2617
FT /evidence="ECO:0000250"
FT DISULFID 2622..2662
FT /evidence="ECO:0000250"
FT DISULFID 2648..2675
FT /evidence="ECO:0000250"
FT DISULFID 2680..2720
FT /evidence="ECO:0000250"
FT DISULFID 2706..2733
FT /evidence="ECO:0000250"
FT DISULFID 2738..2778
FT /evidence="ECO:0000250"
FT DISULFID 2764..2791
FT /evidence="ECO:0000250"
FT DISULFID 2796..2841
FT /evidence="ECO:0000250"
FT DISULFID 2827..2854
FT /evidence="ECO:0000250"
FT DISULFID 2859..2899
FT /evidence="ECO:0000250"
FT DISULFID 2885..2912
FT /evidence="ECO:0000250"
FT DISULFID 2920..2960
FT /evidence="ECO:0000250"
FT DISULFID 2946..2973
FT /evidence="ECO:0000250"
FT DISULFID 2978..3019
FT /evidence="ECO:0000250"
FT DISULFID 3005..3032
FT /evidence="ECO:0000250"
FT DISULFID 3037..3079
FT /evidence="ECO:0000250"
FT DISULFID 3063..3092
FT /evidence="ECO:0000250"
FT DISULFID 3097..3137
FT /evidence="ECO:0000250"
FT DISULFID 3123..3150
FT /evidence="ECO:0000250"
FT DISULFID 3155..3195
FT /evidence="ECO:0000250"
FT DISULFID 3181..3208
FT /evidence="ECO:0000250"
FT DISULFID 3216..3257
FT /evidence="ECO:0000250"
FT DISULFID 3243..3270
FT /evidence="ECO:0000250"
FT DISULFID 3275..3317
FT /evidence="ECO:0000250"
FT DISULFID 3302..3330
FT /evidence="ECO:0000250"
FT VAR_SEQ 102..3564
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009036"
FT VAR_SEQ 3332..3347
FT /note="SKGVREVNETVTKTPV -> I (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009037"
FT CONFLICT 627
FT /note="N -> K (in Ref. 1; AAG54083)"
FT /evidence="ECO:0000305"
FT CONFLICT 1189
FT /note="H -> Y (in Ref. 1; AAG54083)"
FT /evidence="ECO:0000305"
FT CONFLICT 1652
FT /note="I -> V (in Ref. 1; AAG54083)"
FT /evidence="ECO:0000305"
FT CONFLICT 2222
FT /note="L -> P (in Ref. 1; AAG54083)"
FT /evidence="ECO:0000305"
FT CONFLICT 2354
FT /note="E -> K (in Ref. 1; AAG54083)"
FT /evidence="ECO:0000305"
FT CONFLICT 2384
FT /note="Q -> R (in Ref. 1; AAG54083)"
FT /evidence="ECO:0000305"
FT CONFLICT 2721..2731
FT /note="LQDHKWSGQTP -> CRTTSGRGRLT (in Ref. 1; AAG54083)"
FT /evidence="ECO:0000305"
FT CONFLICT 2955
FT /note="S -> F (in Ref. 1; AAG54083)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3564 AA; 387862 MW; BCBC9BB488908858 CRC64;
MTAWRKFKSL LLPLVLAVLC AGLLTAAKGQ NCGGLVQGPN GTIESPGFPH GYPNYANCTW
IIITGERNRI QLSFHTFALE EDFDILSVYD GQPQQGNLKV RLSGFQLPSS IVSTGSLLTL
WFTTDFAVSA QGFKAMYEVL PSHTCGNPGE ILKGVLHGTR FNIGDKIRYS CLSGYILEGH
AILTCIVSPG NGASWDFPAP FCRAEGACGG TLRGTSGSIS SPHFPSEYDN NADCTWTILA
EPGDTIALVF TDFQLEEGYD FLEISGTEAP SIWLTGMNLP SPVISSKNWL RLHFTSDSNH
RRKGFNAQFQ VKKAIELKSR GVKMLPSKDS SHKNSVLTQG GVSLISDMCP DPGIPDNGRR
AGSDFRVGAN VQFSCEDNYV LQGAKGITCQ RVTETLAAWN DHRPICRART CGSNLRGPSG
VITSPNYPVQ YEDNAHCVWV ITTTDPDKVI KLAFEEFELE RGYDTLTVGD AGKVGDTRSV
LYVLTGSSVP DLIVSMSNQM WLHLQSDDSI GSPGFKAVYQ EIEKGGCGDP GIPAYGKRTG
SSFLHGDTLT FECQAAFELV GERVITCQKN NQWSGNKPSC VFSCFFNFTA PSGIILSPNY
PEEYGNNMNC VWLIISEPGS RIHLIFNDFD VEPQFDFLAV KDDGISDITV LGTFSGNEVP
AQLASSGHIV RLEFQSDHST TGRGFNITYT TFGQNECHDP GIPVNGRRFG DRFLLGSSVS
FHCDDGFVKT QGSESITCIL QDGNVVWSST VPRCEAPCGG HLTASSGVIL PPGWPGYYKD
SLNCEWVIEA KPGHSIKITF DRFQTEVNYD TLEVRDGPTS SSPLIGEYHG TQAPQFLIST
GNYMYLLFTT DSSRASVGFL IHYESVTLES DSCLDPGIPV NGQRHGSNFG IRSTVTFSCD
PGYTLSDDEP LVCEKNHQWN HALPSCDALC GGYIHGKSGT VLSPGFPDFY PNSLNCTWTI
EVSHGKGVQM NFHTFHLESS HDYLLITEDG SFSEPVARLT GSVLPHTIKA GLFGNFTAQL
RFISDFSISY EGFNITFAEY DLEPCDDPGV PAFSRRIGFQ FGVGDTLAFT CFQGYRLEGA
TKLTCLGGGR RVWSAPLPRC VAECGASVKG NEGTLLSPNF PSHYDNNHEC IYKIETEAGK
GIHLRARTFQ LFEGDTLKVY DGKDSSSRSL GVFTRSEFMG LVLNSTSNHL RLEFNTNGSD
TAQGFQLTYT SFDLVKCEDP GIPNYGYRIR DDGHFTDTVV LYSCNPGYAM HGSSTLTCLS
GDRRVWDKPM PSCVAECGGL VHAATSGRIL SPGYPAPYDN NLHCTWTIEA DPGKTISLHF
IVFDTETAHD ILKVWDGPVD SNILLKEWSG SALPEDIHST FNSLTLQFDS DFFISKSGFS
IQFSTSIAST CNDPGMPQNG TRYGDSREPG DTITFQCDPG YQLQGPAKIT CVQLNNRFFW
QPDPPSCIAA CGGNLTGPAG VILSPNYPQP YPPGKECDWR IKVNPDFVIA LIFKSFSMEP
SYDFLHIYEG EDSNSPLIGS FQGSQAPERI ESSGNSLFLA FRSDASVGLS GFAIEFKEKP
REACFDPGNI MNGTRIGTDF KLGSTVTYQC DSGYKIVDPS SIECVTGADG KPSWDRALPA
CQAPCGGQYT GSEGVVLSPN YPHNYTAGQM CIYSITVPKE FVVFGQFAYF QTALNDLAEL
FDGTHPQARL LSSLSGSHSG ETLPLATSNQ ILLRFSAKSG ASARGFHFVY QAVPRTSDTQ
CSSVPEPRYG RRIGSEFSAG SIVRFECNPG YLLQGSTAIR CQSVPNALAQ WNDTIPSCVV
PCSGNFTQRR GTILSPGYPE PYGNNLNCVW KIIVSEGSGI QIQVISFATE QNWDSLEIHD
GGDMTAPRLG SFSGTTVPAL LNSTSNQLCL HFQSDISVAA AGFHLEYKTV GLAACQEPAL
PSNGIKIGDR YMVNDVLSFQ CEPGYTLQGR SHISCMPGTV RRWNYPSPLC IATCGGTLTS
MSGVILSPGF PGSYPNNLDC TWKISLPIGY GAHIQFLNFS TEANHDYLEI QNGPYHSSPM
MGQFSGPDLP TSLLSTTHET LIRFYSDHSQ NRQGFKLSYQ AYELQNCPDP PAFQNGFMIN
SDYSVGQSIS FECYPGYILL GHPVLTCQHG TDRNWNYPFP RCDAPCGYNV TSQNGTIYSP
GFPDEYPILK DCLWLVTVPP GHGVYINFTL LQTEAVNDYI AVWDGPDQNS PQLGVFSGNT
ALETAYSSTN QVLLKFHSDF SNGGFFVLNF HAFQLKRCPP PPAVPQADLL TEDEDFEIGD
FVKYQCHPGY TLLGSDTLTC KLSSQLLFQG SPPTCEAQCP ANEVRTESSG VILSPGYPGN
YFNSQTCAWS IKVEPNFNIT LFVDTFQSEK QFDALEVFDG SSGQSPLLVV LSGNHTEQSN
FTSRSNHLYL RWSTDHATSK KGFKIRYAAP YCSLTSTLRN GGILNKTAGA VGSKVHYFCK
PGYRMIGHSN ATCRRNPVGV YQWDSMAPLC QAVSCGIPEA PGNGSFTGNE FTLDSKVTYE
CNEGFKLDAS QEATTVCQED GLWSNRGKPP TCKPVPCPSI EGQLSEHVLW RLVSGSLNEY
GAQVLLSCSP GYFLQGQRLL QCQANGTWST EEDRPRCKVI SCGSLSFPPN GNKIGTLTIY
GATAIFTCNT GYTLVGSHVR ECLANGLWSG SETRCLAGHC GSPDPIVNGH ISGDGFSYRD
TVVYQCNPGF RLVGTSVRIC LQDHKWSGQT PVCVPITCGH PGNPAHGLTN GTEFNLNDLV
NFTCHTGYRL QGASRAQCRS NGQWSSPLPI CRVVNCSDPG SVENAVRHGQ QNFPESFEYG
TSVMYHCKTG FYLLGSSALT CMASGLWDRS LPKCLAISCG HPGVPANAVL TGELFTYGAT
VQYSCKGGQI LTGNSTRVCQ EDSHWSGSLP HCSGNSPGFC GDPGTPAHGS RLGDEFKTKS
LLRFSCEMGH QLRGSAERTC LVNGSWSGVQ PVCEAVSCGN PGTPTNGMIL SSDGILFSSS
VIYACWEGYK TSGLMTRHCT ANGTWTGTAP DCTIISCGDP GTLPNGIQFG TDFTFNKTVS
YQCNPGYLME PPTSPTIRCT KDGTWNQSRP LCKAVLCNQP PPVPNGKVEG SDFRWGASIS
YSCVDGYQLS HSAILSCEGR GVWKGEVPQC LPVFCGDPGT PAEGRLSGKS FTFKSEVFIQ
CKPPFVLVGS SRRTCQADGI WSGIQPTCID PAHTACPDPG TPHFGIQNSS KGYEVGSTVF
FRCRKGYHIQ GSTTRTCLAN LTWSGIQTEC IPHACRQPET PAHADVRAID LPAFGYTLVY
TCHPGFFLAG GSEHRTCKAD MKWTGKSPVC KSKGVREVNE TVTKTPVPSD VFFINSVWKG
YYEYLGKRQP ATLTVDWFNA TSSKVNATFT AASRVQLELT GVYKKEEAHL LLKAFHIKGP
ADIFVSKFEN DNWGLDGYVS SGLERGGFSF QGDIHGKDFG KFKLERQDPS NSDADSSNHY
QGTSSGSVAA AILVPFFALI LSGFAFYLYK HRTRPKVQYN GYAGHENSNG QASFENPMYD
TNLKPTEAKA VRFDTTLNTV CTVV
