CSMD2_HUMAN
ID CSMD2_HUMAN Reviewed; 3487 AA.
AC Q7Z408; B1AM50; E7EUA6; Q53TY4; Q5VT59; Q8N963; Q96Q03; Q9H4V7; Q9H4V8;
AC Q9H4V9; Q9H4W0; Q9H4W1; Q9H4W2; Q9H4W3; Q9H4W4; Q9HCY5; Q9HCY6; Q9HCY7;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=CUB and sushi domain-containing protein 2;
DE AltName: Full=CUB and sushi multiple domains protein 2;
GN Name=CSMD2; Synonyms=KIAA1884;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=12906867; DOI=10.1016/s0888-7543(03)00149-6;
RA Lau W.L., Scholnick S.B.;
RT "Identification of two new members of the CSMD gene family.";
RL Genomics 82:412-415(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM 4), AND VARIANT VAL-2554.
RC TISSUE=Brain;
RA Shimizu A., Sasaki T., Asakawa S., Shimizu N.;
RT "Comparative analysis of CSMD families.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND PROTEIN SEQUENCE OF
RP 2969-3487 (ISOFORM 1).
RC TISSUE=Brain, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2542-3487 (ISOFORM 1), AND TISSUE
RP SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q7Z408-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z408-2; Sequence=VSP_009038, VSP_009039, VSP_009040,
CC VSP_009041, VSP_009042;
CC Name=3;
CC IsoId=Q7Z408-3; Sequence=VSP_009043, VSP_009044, VSP_009045,
CC VSP_009046;
CC Name=4;
CC IsoId=Q7Z408-4; Sequence=VSP_055687, VSP_009040, VSP_055688,
CC VSP_055689;
CC -!- TISSUE SPECIFICITY: Weakly expressed in most tissues, except in brain.
CC Expressed at intermediate level in brain, including cerebellum,
CC substantia nigra, hippocampus and fetal brain. Overexpressed in some
CC head and neck cancer cell lines. {ECO:0000269|PubMed:11572484,
CC ECO:0000269|PubMed:12906867}.
CC -!- SIMILARITY: Belongs to the CSMD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04593.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY210418; AAO34701.1; -; mRNA.
DR EMBL; AB212622; BAD97692.1; -; mRNA.
DR EMBL; AK095627; BAC04593.1; ALT_INIT; mRNA.
DR EMBL; AK127722; BAC87101.1; -; mRNA.
DR EMBL; AC115285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC115286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC116993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139140; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL161643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL355178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL607106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031871; AAH31871.1; -; mRNA.
DR EMBL; AB067471; BAB67777.1; -; mRNA.
DR CCDS; CCDS380.1; -. [Q7Z408-1]
DR CCDS; CCDS60082.1; -. [Q7Z408-4]
DR RefSeq; NP_001268885.1; NM_001281956.1. [Q7Z408-4]
DR RefSeq; NP_443128.2; NM_052896.4. [Q7Z408-1]
DR SMR; Q7Z408; -.
DR BioGRID; 125346; 4.
DR IntAct; Q7Z408; 9.
DR MINT; Q7Z408; -.
DR STRING; 9606.ENSP00000362479; -.
DR GlyGen; Q7Z408; 35 sites.
DR iPTMnet; Q7Z408; -.
DR PhosphoSitePlus; Q7Z408; -.
DR BioMuta; CSMD2; -.
DR DMDM; 116241318; -.
DR MassIVE; Q7Z408; -.
DR PaxDb; Q7Z408; -.
DR PeptideAtlas; Q7Z408; -.
DR PRIDE; Q7Z408; -.
DR ProteomicsDB; 18389; -.
DR ProteomicsDB; 69123; -. [Q7Z408-1]
DR ProteomicsDB; 69124; -. [Q7Z408-2]
DR ProteomicsDB; 69125; -. [Q7Z408-3]
DR Antibodypedia; 2390; 77 antibodies from 14 providers.
DR DNASU; 114784; -.
DR Ensembl; ENST00000373381.9; ENSP00000362479.4; ENSG00000121904.19. [Q7Z408-4]
DR Ensembl; ENST00000373388.7; ENSP00000362486.3; ENSG00000121904.19. [Q7Z408-1]
DR GeneID; 114784; -.
DR KEGG; hsa:114784; -.
DR MANE-Select; ENST00000373381.9; ENSP00000362479.4; NM_001281956.2; NP_001268885.1. [Q7Z408-4]
DR UCSC; uc001bxm.2; human. [Q7Z408-1]
DR CTD; 114784; -.
DR DisGeNET; 114784; -.
DR GeneCards; CSMD2; -.
DR HGNC; HGNC:19290; CSMD2.
DR HPA; ENSG00000121904; Tissue enriched (brain).
DR MIM; 608398; gene.
DR neXtProt; NX_Q7Z408; -.
DR OpenTargets; ENSG00000121904; -.
DR PharmGKB; PA134884681; -.
DR VEuPathDB; HostDB:ENSG00000121904; -.
DR GeneTree; ENSGT00940000159768; -.
DR HOGENOM; CLU_000277_0_0_1; -.
DR InParanoid; Q7Z408; -.
DR OMA; TECLDTG; -.
DR OrthoDB; 2377at2759; -.
DR PhylomeDB; Q7Z408; -.
DR TreeFam; TF316872; -.
DR PathwayCommons; Q7Z408; -.
DR SignaLink; Q7Z408; -.
DR BioGRID-ORCS; 114784; 13 hits in 1032 CRISPR screens.
DR ChiTaRS; CSMD2; human.
DR GeneWiki; CSMD2; -.
DR GenomeRNAi; 114784; -.
DR Pharos; Q7Z408; Tbio.
DR PRO; PR:Q7Z408; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7Z408; protein.
DR Bgee; ENSG00000121904; Expressed in buccal mucosa cell and 135 other tissues.
DR ExpressionAtlas; Q7Z408; baseline and differential.
DR Genevisible; Q7Z408; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00033; CCP; 26.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.60.120.290; -; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 25.
DR SMART; SM00032; CCP; 26.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF49854; SSF49854; 14.
DR SUPFAM; SSF57535; SSF57535; 26.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 26.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Direct protein sequencing;
KW Disulfide bond; Glycoprotein; Membrane; Reference proteome; Repeat; Sushi;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..3487
FT /note="CUB and sushi domain-containing protein 2"
FT /id="PRO_0000079405"
FT TOPO_DOM 1..3408
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 3409..3429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 3430..3487
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..134
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 137..198
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 202..306
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 341..402
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 405..516
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 519..576
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 578..686
FT /note="CUB 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 689..750
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 752..860
FT /note="CUB 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 865..922
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 924..1034
FT /note="CUB 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1037..1096
FT /note="Sushi 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1098..1206
FT /note="CUB 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1209..1269
FT /note="Sushi 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1271..1380
FT /note="CUB 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1383..1443
FT /note="Sushi 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1445..1553
FT /note="CUB 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1556..1617
FT /note="Sushi 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1619..1727
FT /note="CUB 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1733..1794
FT /note="Sushi 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1796..1904
FT /note="CUB 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1907..1966
FT /note="Sushi 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1968..2076
FT /note="CUB 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2121..2180
FT /note="Sushi 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2182..2293
FT /note="CUB 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2292..2353
FT /note="Sushi 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2355..2466
FT /note="CUB 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2466..2528
FT /note="Sushi 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2529..2590
FT /note="Sushi 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2591..2655
FT /note="Sushi 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2656..2713
FT /note="Sushi 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2714..2771
FT /note="Sushi 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2772..2829
FT /note="Sushi 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2833..2890
FT /note="Sushi 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2891..2949
FT /note="Sushi 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2950..3009
FT /note="Sushi 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3010..3067
FT /note="Sushi 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3068..3125
FT /note="Sushi 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3129..3187
FT /note="Sushi 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3188..3247
FT /note="Sushi 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 581
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 680
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 949
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 983
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1009
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1028
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1393
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1566
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1638
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1786
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1799
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1876
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2012
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2430
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2731
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2809
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2878
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2937
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2971
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3001
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3055
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3407
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..52
FT /evidence="ECO:0000250"
FT DISULFID 139..179
FT /evidence="ECO:0000250"
FT DISULFID 165..196
FT /evidence="ECO:0000250"
FT DISULFID 202..228
FT /evidence="ECO:0000250"
FT DISULFID 343..383
FT /evidence="ECO:0000250"
FT DISULFID 369..400
FT /evidence="ECO:0000250"
FT DISULFID 405..431
FT /evidence="ECO:0000250"
FT DISULFID 521..561
FT /evidence="ECO:0000250"
FT DISULFID 547..574
FT /evidence="ECO:0000250"
FT DISULFID 578..604
FT /evidence="ECO:0000250"
FT DISULFID 691..732
FT /evidence="ECO:0000250"
FT DISULFID 717..748
FT /evidence="ECO:0000250"
FT DISULFID 752..778
FT /evidence="ECO:0000250"
FT DISULFID 867..907
FT /evidence="ECO:0000250"
FT DISULFID 893..920
FT /evidence="ECO:0000250"
FT DISULFID 924..950
FT /evidence="ECO:0000250"
FT DISULFID 1039..1079
FT /evidence="ECO:0000250"
FT DISULFID 1065..1094
FT /evidence="ECO:0000250"
FT DISULFID 1098..1124
FT /evidence="ECO:0000250"
FT DISULFID 1211..1252
FT /evidence="ECO:0000250"
FT DISULFID 1238..1267
FT /evidence="ECO:0000250"
FT DISULFID 1271..1298
FT /evidence="ECO:0000250"
FT DISULFID 1385..1425
FT /evidence="ECO:0000250"
FT DISULFID 1411..1441
FT /evidence="ECO:0000250"
FT DISULFID 1445..1471
FT /evidence="ECO:0000250"
FT DISULFID 1558..1598
FT /evidence="ECO:0000250"
FT DISULFID 1584..1615
FT /evidence="ECO:0000250"
FT DISULFID 1619..1645
FT /evidence="ECO:0000250"
FT DISULFID 1735..1775
FT /evidence="ECO:0000250"
FT DISULFID 1761..1792
FT /evidence="ECO:0000250"
FT DISULFID 1796..1822
FT /evidence="ECO:0000250"
FT DISULFID 1909..1949
FT /evidence="ECO:0000250"
FT DISULFID 1935..1964
FT /evidence="ECO:0000250"
FT DISULFID 1968..1994
FT /evidence="ECO:0000250"
FT DISULFID 2123..2163
FT /evidence="ECO:0000250"
FT DISULFID 2149..2178
FT /evidence="ECO:0000250"
FT DISULFID 2182..2208
FT /evidence="ECO:0000250"
FT DISULFID 2294..2336
FT /evidence="ECO:0000250"
FT DISULFID 2322..2351
FT /evidence="ECO:0000250"
FT DISULFID 2355..2383
FT /evidence="ECO:0000250"
FT DISULFID 2468..2509
FT /evidence="ECO:0000250"
FT DISULFID 2495..2526
FT /evidence="ECO:0000250"
FT DISULFID 2531..2573
FT /evidence="ECO:0000250"
FT DISULFID 2557..2588
FT /evidence="ECO:0000250"
FT DISULFID 2593..2638
FT /evidence="ECO:0000250"
FT DISULFID 2624..2653
FT /evidence="ECO:0000250"
FT DISULFID 2658..2698
FT /evidence="ECO:0000250"
FT DISULFID 2684..2711
FT /evidence="ECO:0000250"
FT DISULFID 2716..2756
FT /evidence="ECO:0000250"
FT DISULFID 2742..2769
FT /evidence="ECO:0000250"
FT DISULFID 2774..2814
FT /evidence="ECO:0000250"
FT DISULFID 2800..2827
FT /evidence="ECO:0000250"
FT DISULFID 2835..2875
FT /evidence="ECO:0000250"
FT DISULFID 2861..2888
FT /evidence="ECO:0000250"
FT DISULFID 2893..2934
FT /evidence="ECO:0000250"
FT DISULFID 2920..2947
FT /evidence="ECO:0000250"
FT DISULFID 2952..2994
FT /evidence="ECO:0000250"
FT DISULFID 2978..3007
FT /evidence="ECO:0000250"
FT DISULFID 3012..3052
FT /evidence="ECO:0000250"
FT DISULFID 3038..3065
FT /evidence="ECO:0000250"
FT DISULFID 3070..3110
FT /evidence="ECO:0000250"
FT DISULFID 3096..3123
FT /evidence="ECO:0000250"
FT DISULFID 3131..3172
FT /evidence="ECO:0000250"
FT DISULFID 3158..3185
FT /evidence="ECO:0000250"
FT DISULFID 3190..3232
FT /evidence="ECO:0000250"
FT DISULFID 3217..3245
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..1087
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009038"
FT VAR_SEQ 1..403
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_009043"
FT VAR_SEQ 1..21
FT /note="MRLISIAPGPRWQVQSHHPRS -> MPRSRGRELGRCGCPAGRARGETGISA
FT LVPGAGSRWGRPPPPTPPPLLLLLGCGLLSVSAA (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_055687"
FT VAR_SEQ 443
FT /note="V -> VGGDPGNIQCNKEGLSVETQSLRLRNRSCLLGNSKDNGCCVPNPVHG
FT TGLQV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_009044"
FT VAR_SEQ 576..577
FT /note="FS -> CK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_009045"
FT VAR_SEQ 578..3487
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_009046"
FT VAR_SEQ 1088..1095
FT /note="SSPLPRCV -> MVIVILFP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009039"
FT VAR_SEQ 2075..2116
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009040"
FT VAR_SEQ 2288..2296
FT /note="AYPLTKCPP -> GHLAAVCTL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009041"
FT VAR_SEQ 2297..3487
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009042"
FT VAR_SEQ 2712
FT /note="L -> LATQTKLHSIFYKLLFDVLSSPSLTK (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_055688"
FT VAR_SEQ 2770
FT /note="V -> VPITCGHPGNPVNGLTQGNQFNLNDVVKFVCNPGYMAEGAARSQCLA
FT SGQWSDMLPTCRIINCTDPGHQENSVRQVHASGPHRFSFGTTVSYRCNHGFYLLGTPVL
FT SCQGDGTWDRPRPQCL (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_055689"
FT VARIANT 167
FT /note="L -> P (in dbSNP:rs16836099)"
FT /id="VAR_028081"
FT VARIANT 538
FT /note="H -> R (in dbSNP:rs474474)"
FT /id="VAR_024330"
FT VARIANT 2096
FT /note="R -> K (in dbSNP:rs1874045)"
FT /id="VAR_028082"
FT VARIANT 2117
FT /note="A -> V (in dbSNP:rs11588581)"
FT /id="VAR_028083"
FT VARIANT 2554
FT /note="M -> V (in dbSNP:rs2641962)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_028084"
FT VARIANT 2661
FT /note="L -> R (in dbSNP:rs3820206)"
FT /id="VAR_028085"
FT VARIANT 2661
FT /note="L -> V (in dbSNP:rs34850622)"
FT /id="VAR_050917"
FT VARIANT 3406
FT /note="S -> F (in dbSNP:rs1617468)"
FT /id="VAR_028086"
FT CONFLICT 133
FT /note="V -> A (in Ref. 1; AAO34701)"
FT /evidence="ECO:0000305"
FT CONFLICT 1104
FT /note="G -> A (in Ref. 3; BAC87101)"
FT /evidence="ECO:0000305"
FT CONFLICT 1175
FT /note="V -> E (in Ref. 3; BAC87101)"
FT /evidence="ECO:0000305"
FT CONFLICT 1695
FT /note="E -> G (in Ref. 3; BAC87101)"
FT /evidence="ECO:0000305"
FT CONFLICT 3251
FT /note="S -> N (in Ref. 1; AAO34701, 6; BAB67777 and 2;
FT BAD97692)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3487 AA; 380039 MW; 3A2A1A2911EFC1F4 CRC64;
MRLISIAPGP RWQVQSHHPR SAGQNCTFQL HGPNGTVESP GFPYGYPNYA NCTWTITAEE
QHRIQLVFQS FALEEDFDVL SVFDGPPQPE NLRTRLTGFQ LPATIVSAAT TLSLRLISDY
AVSAQGFHAT YEVLPSHTCG NPGRLPNGIQ QGSTFNLGDK VRYSCNLGFF LEGHAVLTCH
AGSENSATWD FPLPSCRADD ACGGTLRGQS GIISSPHFPS EYHNNADCTW TILAELGDTI
ALVFIDFQLE DGYDFLEVTG TEGSSLWFTG ASLPAPVISS KNWLRLHFTS DGNHRQRGFS
AQYQVKKQIE LKSRGVKLMP SKDNSQKTSV LTQVGVSQGH NMCPDPGIPE RGKRLGSDFR
LGSSVQFTCN EGYDLQGSKR ITCMKVSDMF AAWSDHRPVC RARMCDAHLR GPSGIITSPN
FPIQYDNNAH CVWIITALNP SKVIKLAFEE FDLERGYDTL TVGDGGQDGD QKTVLYILTG
TSVPDLIVST NHQMWLLFQT DGSGSSLGFK ASYEEIEQGS CGDPGIPAYG RREGSRFHHG
DTLKFECQPA FELVGQKAIT CQKNNQWSAK KPGCVFSCFF NFTSPSGVVL SPNYPEDYGN
HLHCVWLILA RPESRIHLAF NDIDVEPQFD FLVIKDGATA EAPVLGTFSG NQLPSSITSS
GHVARLEFQT DHSTGKRGFN ITFTTFRHNE CPDPGVPVNG KRFGDSLQLG SSISFLCDEG
FLGTQGSETI TCVLKEGSVV WNSAVLRCEA PCGGHLTSPS GTILSPGWPG FYKDALSCAW
VIEAQPGYPI KITFDRFKTE VNYDTLEVRD GRTYSAPLIG VYHGTQVPQF LISTSNYLYL
LFSTDKSHSD IGFQLRYETI TLQSDHCLDP GIPVNGQRHG NDFYVGALVT FSCDSGYTLS
DGEPLECEPN FQWSRALPSC EALCGGFIQG SSGTILSPGF PDFYPNNLNC TWIIETSHGK
GVFFTFHTFH LESGHDYLLI TENGSFTQPL RQLTGSRLPA PISAGLYGNF TAQVRFISDF
SMSYEGFNIT FSEYDLEPCE EPEVPAYSIR KGLQFGVGDT LTFSCFPGYR LEGTARITCL
GGRRRLWSSP LPRCVAECGN SVTGTQGTLL SPNFPVNYNN NHECIYSIQT QPGKGIQLKA
RAFELSEGDV LKVYDGNNNS ARLLGVFSHS EMMGVTLNST SSSLWLDFIT DAENTSKGFE
LHFSSFELIK CEDPGTPKFG YKVHDEGHFA GSSVSFSCDP GYSLRGSEEL LCLSGERRTW
DRPLPTCVAE CGGTVRGEVS GQVLSPGYPA PYEHNLNCIW TIEAEAGCTI GLHFLVFDTE
EVHDVLRIWD GPVESGVLLK ELSGPALPKD LHSTFNSVVL QFSTDFFTSK QGFAIQFSVS
TATSCNDPGI PQNGSRSGDS WEAGDSTVFQ CDPGYALQGS AEISCVKIEN RFFWQPSPPT
CIAPCGGDLT GPSGVILSPN YPEPYPPGKE CDWKVTVSPD YVIALVFNIF NLEPGYDFLH
IYDGRDSLSP LIGSFYGSQL PGRIESSSNS LFLAFRSDAS VSNAGFVIDY TENPRESCFD
PGSIKNGTRV GSDLKLGSSV TYYCHGGYEV EGTSTLSCIL GPDGKPVWNN PRPVCTAPCG
GQYVGSDGVV LSPNYPQNYT SGQICLYFVT VPKDYVVFGQ FAFFHTALND VVEVHDGHSQ
HSRLLSSLSG SHTGESLPLA TSNQVLIKFS AKGLAPARGF HFVYQAVPRT SATQCSSVPE
PRYGKRLGSD FSVGAIVRFE CNSGYALQGS PEIECLPVPG ALAQWNVSAP TCVVPCGGNL
TERRGTILSP GFPEPYLNSL NCVWKIVVPE GAGIQIQVVS FVTEQNWDSL EVFDGADNTV
TMLGSFSGTT VPALLNSTSN QLYLHFYSDI SVSAAGFHLE YKTVGLSSCP EPAVPSNGVK
TGERYLVNDV VSFQCEPGYA LQGHAHISCM PGTVRRWNYP PPLCIAQCGG TVEEMEGVIL
SPGFPGNYPS NMDCSWKIAL PVGFGAHIQF LNFSTEPNHD YIEIRNGPYE TSRMMGRFSG
SELPSSLLST SHETTVYFHS DHSQNRPGFK LEYQDLTYSH QISSFLRGFD LSELERTNST
PPVAASYVWD LDPGCEAYEL QECPDPEPFA NGIVRGAGYN VGQSVTFECL PGYQLTGHPV
LTCQHGTNRN WDHPLPKCEV PCGGNITSSN GTVYSPGFPS PYSSSQDCVW LITVPIGHGV
RLNLSLLQTE PSGDFITIWD GPQQTAPRLG VFTRSMAKKT VQSSSNQVLL KFHRDAATGG
IFAIAFSAYP LTKCPPPTIL PNAEVVTENE EFNIGDIVRY RCLPGFTLVG NEILTCKLGT
YLQFEGPPPI CEVHCPTNEL LTDSTGVILS QSYPGSYPQF QTCSWLVRVE PDYNISLTVE
YFLSEKQYDE FEIFDGPSGQ SPLLKALSGN YSAPLIVTSS SNSVYLRWSS DHAYNRKGFK
IRYSAPYCSL PRAPLHGFIL GQTSTQPGGS IHFGCNAGYR LVGHSMAICT RHPQGYHLWS
EAIPLCQALS CGLPEAPKNG MVFGKEYTVG TKAMYSCSEG YHLQAGAEAT AECLDTGLWS
NRNVPPQCVP VTCPDVSSIS VEHGRWRLIF ETQYQFQAQL MLICDPGYYY TGQRVIRCQA
NGKWSLGDST PTCRIISCGE LPIPPNGHRI GTLSVYGATA IFSCNSGYTL VGSRVRECMA
NGLWSGSEVR CLAGHCGTPE PIVNGHINGE NYSYRGSVVY QCNAGFRLIG MSVRICQQDH
HWSGKTPFCV LVSCGHPGSP PHSQMSGDSY TVGAVVRYSC IGKRTLVGNS TRMCGLDGHW
TGSLPHCSGT SVGVCGDPGI PAHGIRLGDS FDPGTVMRFS CEAGHVLRGS SERTCQANGS
WSGSQPECGV ISCGNPGTPS NARVVFSDGL VFSSSIVYEC REGYYATGLL SRHCSVNGTW
TGSDPECLVI NCGDPGIPAN GLRLGNDFRY NKTVTYQCVP GYMMESHRVS VLSCTKDRTW
NGTKPVCKAL MCKPPPLIPN GKVVGSDFMW GSSVTYACLE GYQLSLPAVF TCEGNGSWTG
ELPQCFPVFC GDPGVPSRGR REDRGFSYRS SVSFSCHPPL VLVGSPRRFC QSDGTWSGTQ
PSCIDPTLTT CADPGVPQFG IQNNSQGYQV GSTVLFRCQK GYLLQGSTTR TCLPNLTWSG
TPPDCVPHHC RQPETPTHAN VGALDLPSMG YTLIYSCQEG FSLKGGSEHR TCKADGSWTG
KPPICLEVRP SGRPINTARE PPLTQALIPG DVFAKNSLWK GAYEYQGKKQ PAMLRVTGFQ
VANSKVNATM IDHSGVELHL AGTYKKEDFH LLLQVYQITG PVEIFMNKFK DDHWALDGHV
SSESSGATFI YQGSVKGQGF GQFGFQRLDL RLLESDPESI GRHFASNSSS VAAAILVPFI
ALIIAGFVLY LYKHRRRPKV PFNGYAGHEN TNVRATFENP MYDRNIQPTD IMASEAEFTV
STVCTAV
