CSMD3_HUMAN
ID CSMD3_HUMAN Reviewed; 3707 AA.
AC Q7Z407; Q96PZ3;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=CUB and sushi domain-containing protein 3;
DE AltName: Full=CUB and sushi multiple domains protein 3;
GN Name=CSMD3; Synonyms=KIAA1894;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RX PubMed=12906867; DOI=10.1016/s0888-7543(03)00149-6;
RA Lau W.L., Scholnick S.B.;
RT "Identification of two new members of the CSMD gene family.";
RL Genomics 82:412-415(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP VARIANTS MET-219 AND HIS-3621.
RC TISSUE=Brain, and Testis;
RX PubMed=12943675; DOI=10.1016/s0006-291x(03)01555-9;
RA Shimizu A., Asakawa S., Shimizu N.;
RT "A novel giant gene CSMD3 encoding a protein with CUB and sushi multiple
RT domains: a candidate gene for benign adult familial myoclonic epilepsy on
RT human chromosome 8q23.3-q24.1.";
RL Biochem. Biophys. Res. Commun. 309:143-154(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 661-3707 (ISOFORM 4), AND TISSUE
RP SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=11572484; DOI=10.1093/dnares/8.4.179;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXI. The
RT complete sequences of 60 new cDNA clones from brain which code for large
RT proteins.";
RL DNA Res. 8:179-187(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2271-3707 (ISOFORM 5).
RC TISSUE=Liver;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP VARIANTS [LARGE SCALE ANALYSIS] GLY-322; HIS-3079 AND GLN-3359.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [6]
RP VARIANT CYS-2020.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- FUNCTION: Involved in dendrite development.
CC {ECO:0000250|UniProtKB:Q80T79}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80T79};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80T79}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q7Z407-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z407-2; Sequence=VSP_009047;
CC Name=3;
CC IsoId=Q7Z407-3; Sequence=VSP_009048, VSP_009049;
CC Name=4;
CC IsoId=Q7Z407-4; Sequence=VSP_009050;
CC Name=5;
CC IsoId=Q7Z407-5; Sequence=VSP_009051, VSP_009052;
CC -!- TISSUE SPECIFICITY: Weakly expressed in most tissues, except in brain.
CC Expressed at intermediate level in brain, including cerebellum,
CC substantia nigra, thalamus, spinal cord, hippocampus and fetal brain.
CC Also expressed in testis. {ECO:0000269|PubMed:11572484,
CC ECO:0000269|PubMed:12943675}.
CC -!- DOMAIN: The intracellular region is dispensable for its function.
CC {ECO:0000250|UniProtKB:Q80T79}.
CC -!- SIMILARITY: Belongs to the CSMD family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO34702.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY210419; AAO34702.1; ALT_INIT; mRNA.
DR EMBL; AB114604; BAC82443.1; -; mRNA.
DR EMBL; AB114605; BAC82444.1; -; mRNA.
DR EMBL; AB067481; BAB67787.2; -; mRNA.
DR EMBL; AK126252; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS6315.1; -. [Q7Z407-1]
DR CCDS; CCDS6316.2; -. [Q7Z407-3]
DR CCDS; CCDS6317.1; -. [Q7Z407-2]
DR RefSeq; NP_443132.3; NM_052900.2. [Q7Z407-3]
DR RefSeq; NP_937756.1; NM_198123.1. [Q7Z407-1]
DR RefSeq; NP_937757.1; NM_198124.1. [Q7Z407-2]
DR RefSeq; XP_016868498.1; XM_017013009.1. [Q7Z407-4]
DR SMR; Q7Z407; -.
DR BioGRID; 125350; 3.
DR IntAct; Q7Z407; 1.
DR MINT; Q7Z407; -.
DR STRING; 9606.ENSP00000297405; -.
DR GlyGen; Q7Z407; 41 sites.
DR iPTMnet; Q7Z407; -.
DR PhosphoSitePlus; Q7Z407; -.
DR BioMuta; CSMD3; -.
DR DMDM; 257051058; -.
DR MassIVE; Q7Z407; -.
DR MaxQB; Q7Z407; -.
DR PaxDb; Q7Z407; -.
DR PeptideAtlas; Q7Z407; -.
DR PRIDE; Q7Z407; -.
DR ProteomicsDB; 69118; -. [Q7Z407-1]
DR ProteomicsDB; 69119; -. [Q7Z407-2]
DR ProteomicsDB; 69120; -. [Q7Z407-3]
DR ProteomicsDB; 69121; -. [Q7Z407-4]
DR ProteomicsDB; 69122; -. [Q7Z407-5]
DR Antibodypedia; 26636; 112 antibodies from 22 providers.
DR DNASU; 114788; -.
DR Ensembl; ENST00000297405.10; ENSP00000297405.5; ENSG00000164796.18. [Q7Z407-1]
DR Ensembl; ENST00000343508.7; ENSP00000345799.3; ENSG00000164796.18. [Q7Z407-2]
DR Ensembl; ENST00000455883.2; ENSP00000412263.2; ENSG00000164796.18. [Q7Z407-3]
DR GeneID; 114788; -.
DR KEGG; hsa:114788; -.
DR MANE-Select; ENST00000297405.10; ENSP00000297405.5; NM_198123.2; NP_937756.1.
DR UCSC; uc003ynt.4; human. [Q7Z407-1]
DR CTD; 114788; -.
DR DisGeNET; 114788; -.
DR GeneCards; CSMD3; -.
DR HGNC; HGNC:19291; CSMD3.
DR HPA; ENSG00000164796; Tissue enriched (brain).
DR MIM; 608399; gene.
DR neXtProt; NX_Q7Z407; -.
DR OpenTargets; ENSG00000164796; -.
DR PharmGKB; PA134926063; -.
DR VEuPathDB; HostDB:ENSG00000164796; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000155549; -.
DR HOGENOM; CLU_000277_0_0_1; -.
DR InParanoid; Q7Z407; -.
DR OMA; CENDGTW; -.
DR OrthoDB; 2377at2759; -.
DR PhylomeDB; Q7Z407; -.
DR TreeFam; TF316872; -.
DR PathwayCommons; Q7Z407; -.
DR SignaLink; Q7Z407; -.
DR BioGRID-ORCS; 114788; 14 hits in 1071 CRISPR screens.
DR ChiTaRS; CSMD3; human.
DR GenomeRNAi; 114788; -.
DR Pharos; Q7Z407; Tbio.
DR PRO; PR:Q7Z407; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q7Z407; protein.
DR Bgee; ENSG00000164796; Expressed in middle temporal gyrus and 100 other tissues.
DR ExpressionAtlas; Q7Z407; baseline and differential.
DR Genevisible; Q7Z407; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0045959; P:negative regulation of complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0050773; P:regulation of dendrite development; ISS:UniProtKB.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.60.120.290; -; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 28.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF49854; SSF49854; 14.
DR SUPFAM; SSF57535; SSF57535; 28.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 28.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Sushi; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..3707
FT /note="CUB and sushi domain-containing protein 3"
FT /id="PRO_0000021027"
FT TOPO_DOM 1..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..3630
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 3631..3651
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 3652..3707
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 65..173
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 176..237
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 241..345
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 484..545
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 548..659
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 662..719
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 721..829
FT /note="CUB 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 832..893
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 895..1003
FT /note="CUB 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1008..1065
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1067..1177
FT /note="CUB 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1180..1239
FT /note="Sushi 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1241..1349
FT /note="CUB 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1352..1412
FT /note="Sushi 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1414..1523
FT /note="CUB 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1526..1586
FT /note="Sushi 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1588..1696
FT /note="CUB 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1699..1760
FT /note="Sushi 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1762..1870
FT /note="CUB 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1876..1937
FT /note="Sushi 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1939..2047
FT /note="CUB 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2050..2109
FT /note="Sushi 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2111..2219
FT /note="CUB 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2222..2281
FT /note="Sushi 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2283..2394
FT /note="CUB 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2393..2454
FT /note="Sushi 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2456..2567
FT /note="CUB 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2567..2629
FT /note="Sushi 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2630..2691
FT /note="Sushi 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2692..2756
FT /note="Sushi 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2757..2814
FT /note="Sushi 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2815..2872
FT /note="Sushi 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2873..2930
FT /note="Sushi 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2931..2992
FT /note="Sushi 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2993..3050
FT /note="Sushi 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3054..3111
FT /note="Sushi 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3112..3170
FT /note="Sushi 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3171..3230
FT /note="Sushi 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3231..3288
FT /note="Sushi 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3289..3346
FT /note="Sushi 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3350..3408
FT /note="Sushi 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3409..3468
FT /note="Sushi 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 361
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 409
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 724
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 823
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 966
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1092
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1280
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1536
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1591
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1709
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1781
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1929
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2019
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2155
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2286
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2291
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2495
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2537
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2711
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2742
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2862
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2932
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2952
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3099
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3208
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3364
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3522
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3529
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3612
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3618
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3627
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 65..91
FT /evidence="ECO:0000250"
FT DISULFID 178..218
FT /evidence="ECO:0000250"
FT DISULFID 204..235
FT /evidence="ECO:0000250"
FT DISULFID 241..267
FT /evidence="ECO:0000250"
FT DISULFID 486..526
FT /evidence="ECO:0000250"
FT DISULFID 512..543
FT /evidence="ECO:0000250"
FT DISULFID 548..574
FT /evidence="ECO:0000250"
FT DISULFID 664..704
FT /evidence="ECO:0000250"
FT DISULFID 690..717
FT /evidence="ECO:0000250"
FT DISULFID 721..747
FT /evidence="ECO:0000250"
FT DISULFID 834..875
FT /evidence="ECO:0000250"
FT DISULFID 860..891
FT /evidence="ECO:0000250"
FT DISULFID 895..921
FT /evidence="ECO:0000250"
FT DISULFID 1010..1050
FT /evidence="ECO:0000250"
FT DISULFID 1036..1063
FT /evidence="ECO:0000250"
FT DISULFID 1067..1093
FT /evidence="ECO:0000250"
FT DISULFID 1182..1222
FT /evidence="ECO:0000250"
FT DISULFID 1208..1237
FT /evidence="ECO:0000250"
FT DISULFID 1241..1267
FT /evidence="ECO:0000250"
FT DISULFID 1354..1395
FT /evidence="ECO:0000250"
FT DISULFID 1381..1410
FT /evidence="ECO:0000250"
FT DISULFID 1414..1441
FT /evidence="ECO:0000250"
FT DISULFID 1528..1568
FT /evidence="ECO:0000250"
FT DISULFID 1554..1584
FT /evidence="ECO:0000250"
FT DISULFID 1588..1614
FT /evidence="ECO:0000250"
FT DISULFID 1701..1741
FT /evidence="ECO:0000250"
FT DISULFID 1727..1758
FT /evidence="ECO:0000250"
FT DISULFID 1762..1788
FT /evidence="ECO:0000250"
FT DISULFID 1878..1918
FT /evidence="ECO:0000250"
FT DISULFID 1904..1935
FT /evidence="ECO:0000250"
FT DISULFID 1939..1965
FT /evidence="ECO:0000250"
FT DISULFID 2052..2092
FT /evidence="ECO:0000250"
FT DISULFID 2078..2107
FT /evidence="ECO:0000250"
FT DISULFID 2111..2137
FT /evidence="ECO:0000250"
FT DISULFID 2224..2264
FT /evidence="ECO:0000250"
FT DISULFID 2250..2279
FT /evidence="ECO:0000250"
FT DISULFID 2283..2309
FT /evidence="ECO:0000250"
FT DISULFID 2395..2437
FT /evidence="ECO:0000250"
FT DISULFID 2423..2452
FT /evidence="ECO:0000250"
FT DISULFID 2456..2484
FT /evidence="ECO:0000250"
FT DISULFID 2569..2610
FT /evidence="ECO:0000250"
FT DISULFID 2596..2627
FT /evidence="ECO:0000250"
FT DISULFID 2632..2674
FT /evidence="ECO:0000250"
FT DISULFID 2658..2689
FT /evidence="ECO:0000250"
FT DISULFID 2694..2739
FT /evidence="ECO:0000250"
FT DISULFID 2725..2754
FT /evidence="ECO:0000250"
FT DISULFID 2759..2799
FT /evidence="ECO:0000250"
FT DISULFID 2785..2812
FT /evidence="ECO:0000250"
FT DISULFID 2817..2857
FT /evidence="ECO:0000250"
FT DISULFID 2843..2870
FT /evidence="ECO:0000250"
FT DISULFID 2875..2915
FT /evidence="ECO:0000250"
FT DISULFID 2901..2928
FT /evidence="ECO:0000250"
FT DISULFID 2933..2977
FT /evidence="ECO:0000250"
FT DISULFID 2963..2990
FT /evidence="ECO:0000250"
FT DISULFID 2995..3035
FT /evidence="ECO:0000250"
FT DISULFID 3021..3048
FT /evidence="ECO:0000250"
FT DISULFID 3056..3096
FT /evidence="ECO:0000250"
FT DISULFID 3082..3109
FT /evidence="ECO:0000250"
FT DISULFID 3114..3155
FT /evidence="ECO:0000250"
FT DISULFID 3141..3168
FT /evidence="ECO:0000250"
FT DISULFID 3173..3215
FT /evidence="ECO:0000250"
FT DISULFID 3199..3228
FT /evidence="ECO:0000250"
FT DISULFID 3233..3273
FT /evidence="ECO:0000250"
FT DISULFID 3259..3286
FT /evidence="ECO:0000250"
FT DISULFID 3291..3331
FT /evidence="ECO:0000250"
FT DISULFID 3317..3344
FT /evidence="ECO:0000250"
FT DISULFID 3352..3393
FT /evidence="ECO:0000250"
FT DISULFID 3379..3406
FT /evidence="ECO:0000250"
FT DISULFID 3411..3453
FT /evidence="ECO:0000250"
FT DISULFID 3438..3466
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..59
FT /note="MKGIRKGESRAKESKPWEPGKRRCAKCGRLDFILMKKMGIKSGFTFWNLVFL
FT LTVSCVK -> MWSWFLCWKPVQLDRQTAS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12943675"
FT /id="VSP_009047"
FT VAR_SEQ 344..447
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12906867"
FT /id="VSP_009048"
FT VAR_SEQ 1799..1868
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11572484"
FT /id="VSP_009050"
FT VAR_SEQ 2629..2675
FT /note="AISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQ -> G
FT EVYYAKMNKNMNVRLAPFNVFIWITHFSENGNIRKHIVNSFHKNKA (in isoform
FT 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009051"
FT VAR_SEQ 2676..3707
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_009052"
FT VAR_SEQ 2692..2756
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12906867"
FT /id="VSP_009049"
FT VARIANT 219
FT /note="I -> M (in dbSNP:rs2219898)"
FT /evidence="ECO:0000269|PubMed:12943675"
FT /id="VAR_017404"
FT VARIANT 322
FT /note="W -> G (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035688"
FT VARIANT 2020
FT /note="S -> C (found in a renal cell carcinoma case;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064703"
FT VARIANT 3000
FT /note="V -> L (in dbSNP:rs2193430)"
FT /id="VAR_017405"
FT VARIANT 3079
FT /note="R -> H (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs780986269)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035689"
FT VARIANT 3359
FT /note="R -> Q (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs139968762)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035690"
FT VARIANT 3621
FT /note="N -> H (in dbSNP:rs1592624)"
FT /evidence="ECO:0000269|PubMed:12943675"
FT /id="VAR_017406"
FT CONFLICT 510
FT /note="F -> L (in Ref. 1; AAO34702)"
FT /evidence="ECO:0000305"
FT CONFLICT 726
FT /note="T -> A (in Ref. 1; AAO34702)"
FT /evidence="ECO:0000305"
FT CONFLICT 977
FT /note="S -> I (in Ref. 3; BAB67787)"
FT /evidence="ECO:0000305"
FT CONFLICT 2104
FT /note="I -> T (in Ref. 1; AAO34702)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3707 AA; 406000 MW; 3194CBF8FE56ED76 CRC64;
MKGIRKGESR AKESKPWEPG KRRCAKCGRL DFILMKKMGI KSGFTFWNLV FLLTVSCVKG
FIYTCGGTLK GLNGTIESPG FPYGYPNGAN CTWVIIAEER NRIQIVFQSF ALEEEYDYLS
LYDGHPHPTN FRTRLTGFHL PPPVTSTKSV FSLRLTSDFA VSAHGFKVYY EELQSSSCGN
PGVPPKGVLY GTRFDVGDKI RYSCVTGYIL DGHPQLTCIA NSVNTASWDF PVPICRAEDA
CGGTMRGSSG IISSPSFPNE YHNNADCTWT IVAEPGDTIS LIFTDFQMEE KYDYLEIEGS
EPPTIWLSGM NIPPPIISNK NWLRLHFVTD SNHRYRGFSA PYQGSSTLTH TTSTGELEEH
NRTTTGAIAV ASTPADVTVS SVTAVTIHRL SEEQRVQVTS LRNSGLDPNT SKDGLSPHPA
DTQSTRRRPR HAEQIERTKE LAVVTHRVKK AIDFKSRGFK LFPGKDNSNK FSILNEGGIK
TASNLCPDPG EPENGKRIGS DFSLGSTVQF SCDEDYVLQG AKSITCQRIA EVFAAWSDHR
PVCKVKTCGS NLQGPSGTFT SPNFPFQYDS NAQCVWVITA VNTNKVIQIN FEEFDLEIGY
DTLTIGDGGE VGDPRTVLQV LTGSFVPDLI VSMSSQMWLH LQTDESVGSV GFKVNYKEIE
KESCGDPGTP LYGIREGDGF SNRDVLRFEC QFGFELIGEK SIVCQENNQW SANIPICIFP
CLSNFTAPMG TVLSPDYPEG YGNNLNCIWT IISDPGSRIH LSFNDFDLES QFDFLAVKDG
DSPESPILGT FTGAEVPSHL TSNSHILRLE FQADHSMSGR GFNITYNTFG HNECPDPGIP
INARRFGDNF QLGSSISVIC EEGFIKTQGT ETITCILMDG KVMWSGLIPK CGAPCGGHFS
APSGVILSPG WPGYYKDSLN CEWVIEAEPG HSIKITFERF QTELNYDVLE VHDGPNLLSP
LLGSYNGTQV PQFLFSSSNF IYLLFTTDNS RSNNGFKIHY ESVTVNTYSC LDPGIPVHGR
RYGHDFSIGS TVSFSCDSGY RLSHEEPLLC EKNHWWSHPL PTCDALCGGD VRGPSGTILS
PGYPEFYPNS LNCTWTVDVT HGKGVQFNFH TFHLEDHHDY LLITENGSFT QPLARLTGSD
LPPTINAGLY GNFRAQLRFI SDFSISYEGF NITFSEYNLE PCEDPGIPQY GSRIGFNFGI
GDTLTFSCSS GYRLEGTSEI ICLGGGRRVW SAPLPRCVAE CGASATNNEG ILLSPNYPLN
YENNHECIYS IQVQAGKGIN ISARTFHLAQ GDVLKIYDGK DKTTHLLGAF TGASMRGLTL
SSTSNQLWLE FNSDTEGTDE GFQLVYTSFE LSHCEDPGIP QFGYKISDQG HFAGSTIIYG
CNPGYTLHGS SLLKCMTGER RAWDYPLPSC IAECGGRFKG ESSGRILSPG YPFPYDNNLR
CMWMIEVDPG NIVSLQFLAF DTEASHDILR VWDGPPENDM LLKEISGSLI PEGIHSTLNI
VTIQFDTDFY ISKSGFAIQF SSSVATACRD PGVPMNGTRN GDGREPGDTV VFQCDPGYEL
QGEERITCIQ VENRYFWQPS PPVCIAPCGG NLTGSSGFIL SPNFPHPYPH SRDCDWTITV
NADYVISLAF ISFSIEPNYD FLYIYDGPDS NSPLIGSFQD SKLPERIESS SNTMHLAFRS
DGSVSYTGFH LEYKAKLRES CFDPGNIMNG TRLGMDYKLG STVTYYCDAG YVLQGYSTLT
CIMGDDGRPG WNRALPSCHA PCGSRSTGSE GTVLSPNYPK NYSVGHNCVY SIAVPKEFVV
FGQFVFFQTS LHDVVEVYDG PTQQSSLLSS LSGSHSGESL PLSSGNQITI RFTSVGPITA
KGFHFVYQAV PRTSSTQCSS VPEPRFGRRI GNEFAVGSSV LFDCNPGYIL HGSIAIRCET
VPNSLAQWND SLPTCIVPCG GILTKRKGTI LSPGYPEPYD NNLNCVWKIT VPEGAGIQVQ
VVSFATEHNW DSLDFYDGGD NNAPRLGSYS GTTIPHLLNS TSNNLYLNFQ SDISVSAAGF
HLEYTAIGLD SCPEPQTPSS GIKIGDRYMV GDVVSFQCDQ GYSLQGHSHI TCMPGPVRRW
NYPIPICLAQ CGGAMSDFSG VILSPGFPGN YPSSLDCTWT INLPIGFGVH LQFVNFSTET
IHDYLEVRSG SSETSTVIGR LSGPQIPSSL FSTTHETSLY FHSDYSQNKQ GFHIVYQAYQ
LQSCPDPRPF RNGFVIGNDF TVGQTISFEC FPGYTLIGNS ALTCLHGVSR NWNHPLPRCE
ALCGGNITAM NGTIYSPGYP DEYPNFQDCF WLVRVPPGNG IYINFTVLQT EPIYDFITVW
DGPDQNSPQI GQFSGNTALE SVYSTSNQIL IKFHSDFTTS GFFVLSYHAY QLRVCQPPPP
VPNAEILTED DEFEIGDIIR YQCLPGFTLV GNAILTCRLG ERLQMDGAPP VCQVLCPANE
LRLDSTGVIL SPGYPDSYPN LQMCAWSISV EKGYNITMFV EFFQTEKEFD VLQVYDGPNI
QSPVLISLSG DYSSAFNITS NGHEVFLQWS ADHGNNKKGF RIRYIAFYCS TPESPPHGYI
ISQTGGQLNS VVRWACDRGF RLVGKSSAVC RKSSYGYHAW DAPVPACQAI SCGIPKAPTN
GGILTTDYLV GTRVTYFCND GYRLSSKELT TAVCQSDGTW SNHNKTPRCV VVTCPSINSF
ILEHGRWRIV NGSHYEYKTK VVFSCDPGYH GLGPASIECL PNGTWSWRNE RPYCQIISCG
ELPTPPNGNK IGTQTSYGST AIFTCDLGFM LVGSAVRECL SSGLWSESET RCLAGHCGIP
ELIVNGQVIG ENYGYRDTVV YQCNPGFRLI GSSVRICQQD HNWSGQLPSC VPVSCGHPGS
PIYGRTSGNG FNFNDVVTFS CNIGYLMQGP TKAQCQANRQ WSHPPPMCKV VNCSDPGIPA
NSKRESKIEH GNFTYGTVVF YDCNPGYFLF GSSVLICQPN GQWDKPLPEC IMIDCGHPGV
PPNAVLSGEK YTFGSTVHYS CTGKRSLLGQ SSRTCQLNGH WSGSQPHCSG DATGTCGDPG
TPGHGSRQES NFRTKSTVRY ACDTGYILHG SEERTCLANG SWTGRQPECK AVQCGNPGTT
ANGKVFRIDG TTFSSSVIYS CMEGYILSGP SVRQCTANGT WSGTLPNCTI ISCGDPGIPA
NGLRYGDDYV VGQNVSYMCQ PGYTMELNGS RIRTCTINGT WSGVMPTCRA VTCPTPPQIS
NGRLEGTNFD WGFSISYICS PGYELSFPAV LTCVGNGTWS GEVPQCLPKF CGDPGIPAQG
KREGKSFIYQ SEVSFSCNFP FILVGSSTRI CQADGTWSGS SPHCIEPTQT SCENPGVPRH
GSQNNTFGFQ VGSVVQFHCK KGHLLQGSTT RTCLPDLTWS GIQPECIPHS CKQPETPAHA
NVVGMDLPSH GYTLIYTCQP GFFLAGGTEH RVCRSDNTWT GKVPICEAGS KILVKDPRPA
LGTPSPKLSV PDDVFAQNYI WKGSYNFKGR KQPMTLTVTS FNASTGRVNA TLSNSNMELL
LSGVYKSQEA RLMLRIYLIK VPAHASVKKM KEENWAMDGF VSAEPDGATY VFQGFIQGKD
YGQFGLQRLG LNMSEGSNSS NQPHGTNSSS VAIAILVPFF ALIFAGFGFY LYKQRTAPKT
QYTGCSVHEN NNGQAAFENP MYDTNAKSVE GKAVRFDPNL NTVCTMV
