CSMD3_MOUSE
ID CSMD3_MOUSE Reviewed; 3707 AA.
AC Q80T79; Q3USM6; Q8BVJ0; Q9D588;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-SEP-2009, sequence version 3.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=CUB and sushi domain-containing protein 3;
DE AltName: Full=CUB and sushi multiple domains protein 3;
GN Name=Csmd3; Synonyms=Kiaa1894;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-578 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 805-3670 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=27033969; DOI=10.1016/j.neures.2016.03.003;
RA Mizukami T., Kohno T., Hattori M.;
RT "CUB and Sushi multiple domains 3 regulates dendrite development.";
RL Neurosci. Res. 110:11-17(2016).
CC -!- FUNCTION: Involved in dendrite development.
CC {ECO:0000269|PubMed:27033969}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27033969};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q80T79-3; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80T79-1; Sequence=VSP_027009;
CC Name=3;
CC IsoId=Q80T79-2; Sequence=VSP_009053, VSP_009054, VSP_009055,
CC VSP_009056;
CC -!- TISSUE SPECIFICITY: Expressed in the apical dendrites of postnatal
CC hippocampal neurons (at protein level). {ECO:0000269|PubMed:27033969}.
CC -!- DOMAIN: The intracellular region is dispensable for its function.
CC {ECO:0000269|PubMed:27033969}.
CC -!- SIMILARITY: Belongs to the CSMD family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK140264; BAE24305.1; -; mRNA.
DR EMBL; AK015672; BAB29924.1; -; mRNA.
DR EMBL; AC099596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC101706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC101771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC129189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC130669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC137905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC154881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC157584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC158907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK122567; BAC65849.1; -; mRNA.
DR CCDS; CCDS49602.1; -. [Q80T79-3]
DR RefSeq; NP_001074860.2; NM_001081391.2. [Q80T79-3]
DR RefSeq; XP_011243913.1; XM_011245611.2. [Q80T79-1]
DR SMR; Q80T79; -.
DR BioGRID; 232083; 1.
DR STRING; 10090.ENSMUSP00000098235; -.
DR GlyConnect; 2242; 6 N-Linked glycans (5 sites).
DR GlyGen; Q80T79; 22 sites, 5 N-linked glycans (5 sites).
DR iPTMnet; Q80T79; -.
DR PhosphoSitePlus; Q80T79; -.
DR PaxDb; Q80T79; -.
DR PRIDE; Q80T79; -.
DR ProteomicsDB; 285326; -. [Q80T79-3]
DR ProteomicsDB; 285327; -. [Q80T79-1]
DR ProteomicsDB; 285328; -. [Q80T79-2]
DR Antibodypedia; 26636; 112 antibodies from 22 providers.
DR DNASU; 239420; -.
DR Ensembl; ENSMUST00000100670; ENSMUSP00000098235; ENSMUSG00000022311. [Q80T79-3]
DR Ensembl; ENSMUST00000162830; ENSMUSP00000124775; ENSMUSG00000022311. [Q80T79-3]
DR GeneID; 239420; -.
DR KEGG; mmu:239420; -.
DR UCSC; uc007vqt.1; mouse. [Q80T79-2]
DR UCSC; uc007vqu.2; mouse. [Q80T79-3]
DR CTD; 114788; -.
DR MGI; MGI:2386403; Csmd3.
DR VEuPathDB; HostDB:ENSMUSG00000022311; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000155549; -.
DR InParanoid; Q80T79; -.
DR OMA; CENDGTW; -.
DR OrthoDB; 2377at2759; -.
DR PhylomeDB; Q80T79; -.
DR TreeFam; TF316872; -.
DR BioGRID-ORCS; 239420; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Csmd3; mouse.
DR PRO; PR:Q80T79; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q80T79; protein.
DR Bgee; ENSMUSG00000022311; Expressed in lumbar subsegment of spinal cord and 106 other tissues.
DR ExpressionAtlas; Q80T79; baseline and differential.
DR Genevisible; Q80T79; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0045959; P:negative regulation of complement activation, classical pathway; IBA:GO_Central.
DR GO; GO:0050773; P:regulation of dendrite development; IMP:UniProtKB.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.60.120.290; -; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 28.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF49854; SSF49854; 14.
DR SUPFAM; SSF57535; SSF57535; 28.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 28.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Membrane; Reference proteome; Repeat; Sushi; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..3707
FT /note="CUB and sushi domain-containing protein 3"
FT /id="PRO_0000079406"
FT TOPO_DOM 1..42
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..3630
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 3631..3651
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 3652..3707
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 65..173
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 176..237
FT /note="Sushi 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 241..345
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 484..545
FT /note="Sushi 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 548..659
FT /note="CUB 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 662..719
FT /note="Sushi 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 721..829
FT /note="CUB 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 832..893
FT /note="Sushi 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 895..1003
FT /note="CUB 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1008..1065
FT /note="Sushi 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1067..1177
FT /note="CUB 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1180..1239
FT /note="Sushi 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1241..1349
FT /note="CUB 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1352..1412
FT /note="Sushi 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1414..1523
FT /note="CUB 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1526..1586
FT /note="Sushi 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1588..1696
FT /note="CUB 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1699..1760
FT /note="Sushi 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1762..1870
FT /note="CUB 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 1876..1937
FT /note="Sushi 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 1939..2047
FT /note="CUB 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2050..2109
FT /note="Sushi 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2111..2219
FT /note="CUB 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2222..2281
FT /note="Sushi 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2283..2394
FT /note="CUB 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2393..2454
FT /note="Sushi 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2456..2567
FT /note="CUB 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 2567..2629
FT /note="Sushi 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2630..2691
FT /note="Sushi 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2692..2756
FT /note="Sushi 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2757..2814
FT /note="Sushi 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2815..2872
FT /note="Sushi 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2873..2930
FT /note="Sushi 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2931..2992
FT /note="Sushi 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 2993..3050
FT /note="Sushi 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3054..3111
FT /note="Sushi 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3112..3170
FT /note="Sushi 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3171..3230
FT /note="Sushi 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3231..3288
FT /note="Sushi 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3289..3346
FT /note="Sushi 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3350..3408
FT /note="Sushi 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT DOMAIN 3409..3468
FT /note="Sushi 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3052..3071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 724
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 823
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 966
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1092
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1280
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1536
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1591
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1709
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1781
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1929
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2019
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2155
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2286
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2291
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 65..91
FT /evidence="ECO:0000250"
FT DISULFID 178..218
FT /evidence="ECO:0000250"
FT DISULFID 204..235
FT /evidence="ECO:0000250"
FT DISULFID 241..267
FT /evidence="ECO:0000250"
FT DISULFID 486..526
FT /evidence="ECO:0000250"
FT DISULFID 512..543
FT /evidence="ECO:0000250"
FT DISULFID 548..574
FT /evidence="ECO:0000250"
FT DISULFID 664..704
FT /evidence="ECO:0000250"
FT DISULFID 690..717
FT /evidence="ECO:0000250"
FT DISULFID 721..747
FT /evidence="ECO:0000250"
FT DISULFID 834..875
FT /evidence="ECO:0000250"
FT DISULFID 860..891
FT /evidence="ECO:0000250"
FT DISULFID 895..921
FT /evidence="ECO:0000250"
FT DISULFID 1010..1050
FT /evidence="ECO:0000250"
FT DISULFID 1036..1063
FT /evidence="ECO:0000250"
FT DISULFID 1067..1093
FT /evidence="ECO:0000250"
FT DISULFID 1182..1222
FT /evidence="ECO:0000250"
FT DISULFID 1208..1237
FT /evidence="ECO:0000250"
FT DISULFID 1241..1267
FT /evidence="ECO:0000250"
FT DISULFID 1354..1395
FT /evidence="ECO:0000250"
FT DISULFID 1381..1410
FT /evidence="ECO:0000250"
FT DISULFID 1414..1441
FT /evidence="ECO:0000250"
FT DISULFID 1528..1568
FT /evidence="ECO:0000250"
FT DISULFID 1554..1584
FT /evidence="ECO:0000250"
FT DISULFID 1588..1614
FT /evidence="ECO:0000250"
FT DISULFID 1701..1741
FT /evidence="ECO:0000250"
FT DISULFID 1727..1758
FT /evidence="ECO:0000250"
FT DISULFID 1762..1788
FT /evidence="ECO:0000250"
FT DISULFID 1878..1918
FT /evidence="ECO:0000250"
FT DISULFID 1904..1935
FT /evidence="ECO:0000250"
FT DISULFID 1939..1965
FT /evidence="ECO:0000250"
FT DISULFID 2052..2092
FT /evidence="ECO:0000250"
FT DISULFID 2078..2107
FT /evidence="ECO:0000250"
FT DISULFID 2111..2137
FT /evidence="ECO:0000250"
FT DISULFID 2224..2264
FT /evidence="ECO:0000250"
FT DISULFID 2250..2279
FT /evidence="ECO:0000250"
FT DISULFID 2283..2309
FT /evidence="ECO:0000250"
FT DISULFID 2395..2437
FT /evidence="ECO:0000250"
FT DISULFID 2423..2452
FT /evidence="ECO:0000250"
FT DISULFID 2456..2484
FT /evidence="ECO:0000250"
FT DISULFID 2569..2610
FT /evidence="ECO:0000250"
FT DISULFID 2596..2627
FT /evidence="ECO:0000250"
FT DISULFID 2632..2674
FT /evidence="ECO:0000250"
FT DISULFID 2658..2689
FT /evidence="ECO:0000250"
FT DISULFID 2694..2739
FT /evidence="ECO:0000250"
FT DISULFID 2725..2754
FT /evidence="ECO:0000250"
FT DISULFID 2759..2799
FT /evidence="ECO:0000250"
FT DISULFID 2785..2812
FT /evidence="ECO:0000250"
FT DISULFID 2817..2857
FT /evidence="ECO:0000250"
FT DISULFID 2843..2870
FT /evidence="ECO:0000250"
FT DISULFID 2875..2915
FT /evidence="ECO:0000250"
FT DISULFID 2901..2928
FT /evidence="ECO:0000250"
FT DISULFID 2933..2977
FT /evidence="ECO:0000250"
FT DISULFID 2963..2990
FT /evidence="ECO:0000250"
FT DISULFID 2995..3035
FT /evidence="ECO:0000250"
FT DISULFID 3021..3048
FT /evidence="ECO:0000250"
FT DISULFID 3056..3096
FT /evidence="ECO:0000250"
FT DISULFID 3082..3109
FT /evidence="ECO:0000250"
FT DISULFID 3114..3155
FT /evidence="ECO:0000250"
FT DISULFID 3141..3168
FT /evidence="ECO:0000250"
FT DISULFID 3173..3215
FT /evidence="ECO:0000250"
FT DISULFID 3199..3228
FT /evidence="ECO:0000250"
FT DISULFID 3233..3273
FT /evidence="ECO:0000250"
FT DISULFID 3259..3286
FT /evidence="ECO:0000250"
FT DISULFID 3291..3331
FT /evidence="ECO:0000250"
FT DISULFID 3317..3344
FT /evidence="ECO:0000250"
FT DISULFID 3352..3393
FT /evidence="ECO:0000250"
FT DISULFID 3379..3406
FT /evidence="ECO:0000250"
FT DISULFID 3411..3453
FT /evidence="ECO:0000250"
FT DISULFID 3438..3466
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..1061
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009053"
FT VAR_SEQ 1062..1064
FT /note="TCD -> MAK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009054"
FT VAR_SEQ 1239..1250
FT /note="AECGASATNNEG -> GTWSAAFICLYV (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009055"
FT VAR_SEQ 1251..3707
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_009056"
FT VAR_SEQ 1799..1868
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_027009"
FT CONFLICT 545..578
FT /note="VKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVI -> GLSLSLSLSLCVCV
FT CVCLCDCVLICVYLCSYSNF (in Ref. 1; BAE24305)"
FT /evidence="ECO:0000305"
FT CONFLICT 1183
FT /note="E -> G (in Ref. 1; BAB29924)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3707 AA; 405762 MW; AA185621A294A0DF CRC64;
MKGSRKGESR AKESKPREPG TRRCAKCGRL DFILKKKMGI KSGFTFWNLV FLLTLSCVKG
FIYTCGGTLK GLNGTIESPG FPYGYPNGAN CTWVIIAEER NRIQIVFQSF ALEEEYDYLS
LYDGHPHPTN FRTRLTGFHL PPPVTSTKSV FSLRLTSDFA VSAHGFKVYY EELQSSSCGN
PGVPPKGVLY GTRFDVGDKI RYSCVTGYIL DGHPQLTCIA NSVNTASWDF PVPICRAEDA
CGGTMRGSSG IISSPGFPNE YHNNADCTWT IVAEPGDTIS LIFTDFQMEE KYDYLEIEGS
EPPTIWLSGM NIPPPIISNK NWLRLHFVTD SNHRYRGFSA PYQGSSPLTL TASIGELEEH
IRTATGAIDV ASTPADVTVS SVTAVTSHRL SEEQRVQVRS LSDSGLDPNT PEDQLSPHQA
DTQSTSRRPR NAEQIERTKE LAVVTHRVKK AIDFKSRGFK LFPGKDNSNK FSLLNEGGIK
TASNLCPDPG EPENGKRFGS DFSLGSTVQF SCDEDYVLQG AKSITCQRIA EVFAAWSDHR
PVCKVKTCGS NLQGPSGTFT SPNFPFQYDS NAQCVWVITA VNTNKVIQIN FEEFDLEIGY
DTLTIGDGGE VGDPRTVLQV LTGSFVPDLI VSMRSQMWLH LQTDESVGSV GFKVNYKEIE
KESCGDPGTP LYGIREGDGF SNRDVLRFEC QFGFELIGEK SIVCQENNQW SANIPICIFP
CLSNFTAPMG TVLSPDYPEG YGNNLNCIWT IISDPGSRIH LSFNDFDLES QFDFLAVKDG
DSPDSPILGT FTGAEVPSHL TSNSHILRLE FQADHSMSGR GFNITYNTFG HNECPDPGIP
INARRFGDNF QLGSSISVIC EEGFIKTQGT ETITCILMDG KVMWSGPIPR CGAPCGGHFS
APSGVILSPG WPGYYKDSLN CEWVIEAEPG HSIKITFERF QTELNYDVLE VHDGPNLLSP
LLGSYNGTQV PQFLFSSSNF IYLLFTTDNS RSNNGFKIHY ESVTVNTYSC LDPGIPVHGR
RYGHDFSIGS TVSFSCDPGY RLSHEEPLLC EKNHWWSHPL PTCDALCGGD VRGPSGTILS
PGYPEFYPNS LNCTWTVDVT HGKGVQFNFH TFHLEDHHDY LLITENGSFT QPLARLTGSE
LPSTINAGLY GNFRAQLRFI SDFSISYEGF NITFSEYNLE PCEDPGIPQY GSRVGFSFGV
GDTLTFSCSL GYRLEGSSEI ICLGGGRRVW SAPLPRCVAE CGASATNNEG ILLSPNYPLN
YENNHECIYS LQVQAGKGIN ISARTFHLAQ GDVLKIYDGK DKTTHLLGAF TGASMRGLTL
SSTSNQLWLE FNSDSEGTDE GFQLVYTSFE LSHCEDPGIP QFGYKISDQG HFAGSTIIYG
CNPGYTLHGS SLLKCMTGER RAWDYPLPSC IAECGGRFKG ESSGRILSPG YPFPYDNNLR
CMWMIEVDPG NIVSLQFLAF DTEASHDILR VWDGPPENEM LLKEVSGSLI PDGIHSTLNI
VTIQFDTDFY ISKSGFAIQF SSSVATACRD PGVPMNGTRN GDGREPGDTV VFQCDPGYEL
QGQERITCIQ VENRYFWQPS PPVCIAPCGG NLTGSSGFIL SPNFPHPYPH SRDCDWTISV
NTDYVISLAF ISFSIEPNYD FLYIYDGPDS NSPLIGSFQD SKLPERIESS SNTMHLAFRS
DGSVSYTGFH LEYKAKLRES CFDPGNIMNG TRLGMDYKLG STVTYYCDAG YVLQGYSTLT
CIMGDDGRPG WNRVLPSCHA PCGSRSTGSE GTVLSPNYPK NYSVDHNCVY SIAVPKEFVV
FGQFVFFQTS LHDVVEVFDG PTQQSPLLSS LSGSHSGESL PLSSGNQITI RFTSVGPITA
KGFHFVYQAV PRTSSTQCSS VPEPRFGRRI GNDFAVGSLV LFECNPGYIL HGSRAIRCET
VPNSLAQWND SLPTCIVPCG GILTKRKGTI LSPGYPEPYD NNLNCVWKIT VPEGAGIQVQ
VVSFATEHNW DSLDFYDGGD NNAPRLGSYS GTTIPHLLNS TSNNLYLNFQ SDISVSAAGF
HLEYTAIGLD SCPEPQTPSS GIKVGDRYMV GDVVSFQCDQ GYSLQGHSHI TCMPGPVRRW
NYPIPICLAQ CGGAMSDFSG VILSPGFPGN YPSSLDCTWT IKLPIGFGVH LQFVNFSTET
IHDYLEVRSG SSEISTVIGR LSGPQIPSSL FSTTHETSLY FHSDYSQNKQ GFHIVYQAYQ
LQSCPDPRPF RNGFVIGNDF TVGQTISFEC FPGYTLIGNS ALTCLHGVSR NWNHPLPRCE
ALCGGNITAM NGTIYSPGYP DEYPNFQDCF WLVRVPPGNG IYINFTVLQT EPIYDFITVW
DGPDQNSPQI GQFSGNTALE SVYSTSNQIL IKFHSDFTTS GFFVLSYHAY QLRVCQPPPP
VPNAEILTED DEFEIGDIIR YQCLPGFTLV GNAILTCRLG ERLQMDGAPP VCQVLCPANE
LRLDSTGVIL SPGYPDSYPN LQMCAWSISV EKGYNISMFV EFFQTEKEFD VLQVYDGPNI
QSPVLISLSG DYSAAFNVTS NGHEVFLQWS ADHGNNKKGF RIRYIAFYCS TPESPPHGYI
ISQTGGQLNS VVRWACDRGF RLVGKSSAVC RKSSYGYHSW DAPVPACQAI SCGIPKAPTN
GGILTTDYLV GTRVTYFCND GYRLSSKELT TATCQSDGTW SNHNKTPRCV VVTCPSINSF
TLDHGRWRIV NGSHYEYKTK VVFSCDPGYH GLGPASIECL PNGTWSWRTE RPYCQIISCG
ELPTPPNGNK IGTQTSYGST AIFTCDLGFM LVGSAVRECL SSGLWSGSET RCLAGHCGIP
ELIVNGQVIG ENYGYRDTVV YQCNPGFRLI GSSVRICQQD HNWSGQLPSC VPVSCGHPGS
PIYGRTSGNG FNFNDVVTFS CNIGYLMQGP TKAQCQANRQ WSHPPPVCKV VNCSDPGIPA
NSKRESKIEH GNFTYGTVVF YDCNPGYFLF GSSVLICQPN GQWDKPLPEC IMIDCGHPGI
PPNAVLSGEK YTFGSTVHYS CTGKRSLLGQ ASRTCQLNGH WSGSQPHCSG DTTGTCGDPG
TPGHGSRQES DFRTKSTVRF ACDTGYILYG SEERTCLSNG SWTGRQPECK AVQCGNPGTT
ANGKVFRIDG TTFSSSVIYS CLEGYILSGP SVRQCTANGT WSGSLPNCTI ISCGDPGIPA
NGLRYGDDFV VGQNVSYMCQ PGYTIELNGS RVRTCTTNGT WSGVMPTCRA VTCSTPPQIS
NGRLEGTNFD WGFSISYICS AGYELSFPAV LTCVGNGTWS GEVPQCLPKF CGDPGIPSQG
KREGKSFIYQ SEVSFSCNSP FILVGSSTRL CQTDGTWSGS SPHCIEPTRT SCENPGVPRH
GSQNNTFGFQ VGSVVQFHCK KGHLLQGSTT RTCLPDLTWS GIQPECIPHS CKQPESPAHA
NVVGMDLPSH GYTLIYTCQP GFFLAGGTEH RVCRSDNTWT GKVPVCEAGS KILVKDPRPA
LGTPSPKLSV PDDVFAQNYI WKGSYNFKGR KQPMTLTVTS FNASTGRVNA TLSNSDMELL
LSGVYKSQEA RLMLHIYLIK VPAHASVKKM KEENWAMDGF VSAEPDGATY VFQGFIKGKD
YGQFGLQRLG LNTSEGSNSS NQPHGTNSSS VAIAILVPFF ALIFAGFGFY LYKQRTAPKT
QYTGCSVHEN NNGQAAFENP MYDTNAKSVE GKAVRFDPNL NTVCTMV
